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Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy

Cingolani, LA; Goda, Y; (2008) Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy. NAT REV NEUROSCI , 9 (5) 344 - 356. 10.1038/nrn2373.

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Abstract

Synapse regulation exploits the capacity of actin to function as a stable structural component or as a dynamic filament. Beyond its well-appreciated role in eliciting visible morphological changes at the synapse, the emerging picture points to an active contribution of actin to the modulation of the efficacy of pre- and postsynaptic terminals. Moreover, by engaging distinct pools of actin and divergent signalling pathways, actin-dependent morphological plasticity could be uncoupled from modulation of synaptic strength. The aim of this Review is to highlight some of the recent progress in elucidating the role of the actin cytoskeleton in synaptic function.

Type:Article
Title:Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy
DOI:10.1038/nrn2373
Keywords:LONG-TERM POTENTIATION, DENDRITIC SPINE MORPHOLOGY, CENTRAL-NERVOUS-SYSTEM, CULTURED HIPPOCAMPAL-NEURONS, FROG NEUROMUSCULAR JUNCTION, AMPA RECEPTOR TRAFFICKING, F-ACTIN, NMDA RECEPTOR, EXCITATORY SYNAPSES, MENTAL-RETARDATION

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