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alpha,alpha '-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes

Galman, JL; Steadman, D; Bacon, S; Morris, P; Smith, MEB; Ward, JM; ... Hailes, HC; + view all (2010) alpha,alpha '-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes. Chemical Communications , 46 (40) 7608 - 7610. 10.1039/c0cc02911d. Green open access

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Abstract

Transketolase mutants have been identified that accept aromatic acceptors with good stereoselectivities, in particular benzaldehyde for which the wild type enzyme showed no activity.

Type:Article
Title:alpha,alpha '-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes
Open access status:An open access version is available from UCL Discovery
DOI:10.1039/c0cc02911d
Publisher version:http://dx.doi.org/10.1039/c0cc02911d
Language:English
Additional information:Galman, JL and Steadman, D and Bacon, S and Morris, P and Smith, MEB and Ward, JM and Dalby, PA and Hailes, HC (2010) alpha,alpha '-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes. Chemical Communications , 46 (40) 7608 – 7610 Reproduced by permission of The Royal Society of Chemistry
Keywords:ESCHERICHIA-COLI TRANSKETOLASE, CARBON BOND FORMATION, BIOCATALYTIC SYNTHESIS, SUBSTRATE-SPECIFICITY, CATALYZED SYNTHESIS, DIRECTED EVOLUTION, AMINO-ALCOHOLS, TRANSAMINASE, REACTOR
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Biochemical Engineering
UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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