Galman, JL and Steadman, D and Bacon, S and Morris, P and Smith, MEB and Ward, JM and Dalby, PA and Hailes, HC (2010) alpha,alpha '-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes. Chemical Communications , 46 (40) 7608 - 7610. 10.1039/c0cc02911d.
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Abstract
Transketolase mutants have been identified that accept aromatic acceptors with good stereoselectivities, in particular benzaldehyde for which the wild type enzyme showed no activity.
| Type: | Article |
|---|---|
| Title: | alpha,alpha '-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c0cc02911d |
| Publisher version: | http://dx.doi.org/10.1039/c0cc02911d |
| Language: | English |
| Additional information: | Galman, JL and Steadman, D and Bacon, S and Morris, P and Smith, MEB and Ward, JM and Dalby, PA and Hailes, HC (2010) alpha,alpha '-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes. Chemical Communications , 46 (40) 7608 – 7610 Reproduced by permission of The Royal Society of Chemistry |
| Keywords: | ESCHERICHIA-COLI TRANSKETOLASE, CARBON BOND FORMATION, BIOCATALYTIC SYNTHESIS, SUBSTRATE-SPECIFICITY, CATALYZED SYNTHESIS, DIRECTED EVOLUTION, AMINO-ALCOHOLS, TRANSAMINASE, REACTOR |
| UCL classification: | UCL > School of BEAMS > Faculty of Engineering Science > Biochemical Engineering UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry |
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