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Gene transfer for erythropoiesis enhancement.

Naffakh, N; Danos, O; (1996) Gene transfer for erythropoiesis enhancement. Mol Med Today , 2 (8) pp. 343-348.

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Abstract

The spectrum of anemias treated with recombinant human erythropoietin is rapidly broadening. Lifelong treatment with very high doses is now under evaluation for beta-thalassemia and sickle cell anemia. These indications make it worthwhile to search for methods that will allow a permanent systemic delivery of the hormone. Here, we review experimental gene-transfer-based procedures for erythropoietin delivery in vivo. In mice, both ex vivo and direct in vivo approaches for gene transfer have resulted in the long-term production of therapeutic levels of the hormone. Gene transfer of erythropoietin could become a viable alternative to the injection of the purified recombinant protein once reliable procedures for controlling transgene expression are available.

Type: Article
Title: Gene transfer for erythropoiesis enhancement.
Location: England
Keywords: Anemia, Animals, Cell Transplantation, Erythropoiesis, Erythropoietin, Gene Transfer Techniques, Genetic Therapy, Humans, Recombinant Proteins, beta-Thalassemia
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/168081
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