UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Seroprevalence of common vaccine-preventable viral infections in HIV-positive adults

Molton, J; Smith, C; Chaytor, S; Maple, P; Brown, K; Johnson, M; Geretti, AM; (2010) Seroprevalence of common vaccine-preventable viral infections in HIV-positive adults. J INFECTION , 61 (1) 73 - 80. 10.1016/j.jinf.2010.04.004.

Full text not available from this repository.

Abstract

Objectives: Guidelines recommend a proactive approach for offering vaccination to susceptible HIV-infected patients. The size of the HIV-positive population that remains susceptible to vaccine-preventable infections is largely unknown. The study determined serostatus and recalled infection and vaccination history for measles, mumps, rubella, varicella-zoster virus (VZV), hepatitis A, and hepatitis B among HIV-positive adults accessing routine care.Methods: The study recruited 200 consecutive patients with a median CD4 count of 461 (inter-quartile range 326, 641) cells/mm(3); 62.5% were on suppressive antiretroviral therapy. Patients underwent serological testing and completed a questionnaire about recalled infection and vaccination history.Results: Seronegativity rates were 7.0% [95% confidence interval 3.9-11.5%] for measles, 12.0% [7.5-16.5%] for mumps, 5.0% [2.4-9.0%] for rubella, 1.5% [0.3-4.3%] for VZV, 19.5% [14.0-25.0%] for hepatitis A, and 22.5% [16.7-28.3%] for hepatitis B. For hepatitis B, seropositivity rates were 6.5% [3.5-10.9%] for surface antigen, 38.0% [31.3-44.7%] for anti-core antibody, and 33.0% [26.5-39.5%] for anti-surface antibody alone. While patients who recalled a history of infection were generally seropositive, up to 50.5% of patients were unsure of their vaccination history.Conclusions: A proportion of HIV-positive adults lack evidence of immunity against common, vaccine-preventable viral infections. Efforts are needed to improve knowledge and records of vaccination history. (c) 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserved.

Type: Article
Title: Seroprevalence of common vaccine-preventable viral infections in HIV-positive adults
DOI: 10.1016/j.jinf.2010.04.004
Keywords: HIV, MMR, VZV, Hepatitis A, Hepatitis B, HUMAN-IMMUNODEFICIENCY-VIRUS, VARICELLA-ZOSTER-VIRUS, HEPATITIS-A VACCINE, RESOLVED FLUORESCENCE IMMUNOASSAY, ACTIVE ANTIRETROVIRAL THERAPY, WESTERN-EUROPE, HOMOSEXUAL-MEN, B INFECTION, PREVALENCE, MEASLES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/168051
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item