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Presynaptic GABA(A) receptors enhance transmission and LTP induction at hippocampal mossy fiber synapses

Ruiz, A; Campanac, E; Scott, RS; Rusakov, DA; Kullmann, DM; (2010) Presynaptic GABA(A) receptors enhance transmission and LTP induction at hippocampal mossy fiber synapses. NAT NEUROSCI , 13 (4) 431 - U47. 10.1038/nn.2512.

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Abstract

Presynaptic GABA(A) receptors (GABA(A)Rs) occur at hippocampal mossy fiber synapses. Whether and how they modulate orthodromic signaling to postsynaptic targets is poorly understood. We found that an endogenous neurosteroid that is selective for high-affinity. subunit-containing GABA(A)Rs depolarized rat mossy fiber boutons, enhanced action potential-dependent Ca2+ transients and facilitated glutamatergic transmission to pyramidal neurons. Conversely, blocking GABA(A)Rs hyperpolarized mossy fiber boutons, increased their input resistance, decreased spike width and attenuated action potential-dependent presynaptic Ca2+ transients, indicating that a subset of presynaptic GABA receptors are tonically active. Blocking GABA(A)Rs also interfered with the induction of long-term potentiation at mossy fiber-CA3 synapses. Presynaptic GABA(A)Rs therefore facilitate information flow to the hippocampus both directly and by enhancing LTP.

Type: Article
Title: Presynaptic GABA(A) receptors enhance transmission and LTP induction at hippocampal mossy fiber synapses
DOI: 10.1038/nn.2512
Keywords: DENTATE GYRUS, DELTA-SUBUNIT, TRANSMITTER RELEASE, PYRAMIDAL NEURONS, GLUTAMATE RELEASE, GRANULE CELLS, RAT, ACTIVATION, INHIBITION, MODULATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/168039
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