Biochemical markers of acute pancreatitis.
J CLIN PATHOL
340 - 344.
Serum amylase remains the most commonly used biochemical marker for the diagnosis of acute pancreatitis, but its sensitivity can be reduced by late presentation, hypertriglyceridaemia, and chronic alcoholism. Urinary trypsinogen-2 is convenient, of comparable diagnostic accuracy, and provides greater (99%) negative predictive value. Early prediction of the severity of acute pancreatitis can be made by well validated scoring systems at 48 hours, but the novel serum markers procalcitonin and interleukin 6 allow earlier prediction (12 to 24 hours after admission). Serum alanine transaminase >150 IU/l and jaundice suggest a gallstone aetiology, requiring endoscopic retrograde cholangiopancreatography. For obscure aetiologies, serum calcium and triglycerides should be measured. Genetic polymorphisms may play an important role in "idiopathic'' acute recurrent pancreatitis.
|Title:||Biochemical markers of acute pancreatitis|
|Open access status:||An open access publication|
|Publisher version:||http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC18603...|
|Keywords:||C-REACTIVE PROTEIN, TRYPSINOGEN ACTIVATION PEPTIDE, NECROTIZING PANCREATITIS, CLASSIFICATION-SYSTEM, CATIONIC TRYPSINOGEN, RAPID MEASUREMENT, EARLY PREDICTION, SERUM MARKERS, APACHE-II, SEVERITY|
|UCL classification:||UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
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