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Biochemical markers of acute pancreatitis

Matull, WR; Pereira, SP; O'Donohue, JW; (2006) Biochemical markers of acute pancreatitis. J CLIN PATHOL , 59 (4) 340 - 344. 10.1136/jcp.2002.002923. Gold open access

Abstract

Serum amylase remains the most commonly used biochemical marker for the diagnosis of acute pancreatitis, but its sensitivity can be reduced by late presentation, hypertriglyceridaemia, and chronic alcoholism. Urinary trypsinogen-2 is convenient, of comparable diagnostic accuracy, and provides greater (99%) negative predictive value. Early prediction of the severity of acute pancreatitis can be made by well validated scoring systems at 48 hours, but the novel serum markers procalcitonin and interleukin 6 allow earlier prediction (12 to 24 hours after admission). Serum alanine transaminase >150 IU/l and jaundice suggest a gallstone aetiology, requiring endoscopic retrograde cholangiopancreatography. For obscure aetiologies, serum calcium and triglycerides should be measured. Genetic polymorphisms may play an important role in "idiopathic'' acute recurrent pancreatitis.

Type:Article
Title:Biochemical markers of acute pancreatitis
Open access status:An open access publication
DOI:10.1136/jcp.2002.002923
Publisher version:http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC1860356/?tool=pubmed
Keywords:C-REACTIVE PROTEIN, TRYPSINOGEN ACTIVATION PEPTIDE, NECROTIZING PANCREATITIS, CLASSIFICATION-SYSTEM, CATIONIC TRYPSINOGEN, RAPID MEASUREMENT, EARLY PREDICTION, SERUM MARKERS, APACHE-II, SEVERITY

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