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Long-term effects of ketamine: evidence for a persisting impairment of source memory in recreational users

Morgan, CJA; Riccelli, M; Maitland, CH; Curran, HV; (2004) Long-term effects of ketamine: evidence for a persisting impairment of source memory in recreational users. DRUG ALCOHOL DEPEN , 75 (3) 301 - 308. 10.1016/j.drugalcdep.2004.03.006.

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Abstract

Rationale: Ketamine is an N-methyl-D-aspartate (NMDA)-receptor antagonist that is increasingly being used as a recreational drug. Previous research has shown gross generalised verbal memory impairments persisting 3 days after ketamine use in chronic users, however episodic memory has not specifically investigated in this population. Objective: To determine whether ketamine, on the night of drug use (day 0) and 3 days later, is associated with impaired episodic memory as assessed by a source memory task. Methods: Twenty ketamine users and 20 poly-drug controls were compared on a source memory task both on day 0 and 3. Participants also completed questionnaires on both days indexing schizophrenic-like and dissociative symptoms. Results: On day 0, ketamine abusers were impaired on both source memory and item recognition and scored more highly on schizophrenic and dissociative symptom scales compared to poly-drug controls. On day 3 ketamine abusers only displayed source memory impairments and these positively correlated with the level of schizophrenic-like symptoms on day 0. No differences on day 3 in schizophrenic-like or dissociative symptoms were observed. Conclusions: Ketamine abusers exhibit a persisting deficit in source memory on day 3 but not in item recognition. These findings suggest that repeated use of ketamine produces chronic impairments to episodic memory. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

Type: Article
Title: Long-term effects of ketamine: evidence for a persisting impairment of source memory in recreational users
DOI: 10.1016/j.drugalcdep.2004.03.006
Keywords: ketamine, abuse, source memory, chronic effects, NMDA-antagonist, cognition, NMDA RECEPTOR HYPOFUNCTION, HEALTHY-VOLUNTEERS, RECOGNITION MEMORY, PHENCYCLIDINE, SCHIZOPHRENIA, DEGENERATION, DYSFUNCTION, RETRIEVAL, COGNITION, DEFICITS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: http://discovery.ucl.ac.uk/id/eprint/167436
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