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Calcium and apoptosis: facts and hypotheses

Rizzuto, R; Pinton, P; Ferrari, D; Chami, M; Szabadkai, G; Magalhaes, PJ; Di Virgilio, F; (2003) Calcium and apoptosis: facts and hypotheses. ONCOGENE , 22 (53) 8619 - 8627. 10.1038/sj.onc.1207105.

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Abstract

Although longstanding experimental evidence has associated alterations of calcium homeostasis to cell death, only in the past few years the role of calcium in the signaling of apoptosis has been extensively investigated. In this review, we will summarize the current knowledge, focusing on (i) the effect of the proteins of the Bcl-2 family on ER Ca2+ levels, (ii) the action of the proteolytic enzymes of apoptosis on the Ca2+ signaling machinery, (iii) the ensuing alterations on the signaling patterns of extracellular stimuli, and (iv) the intracellular targets of 'apoptotic' Ca2+ signals, with special emphasis on the mitochondria and cytosolic Ca2+-dependent enzymes.

Type: Article
Title: Calcium and apoptosis: facts and hypotheses
DOI: 10.1038/sj.onc.1207105
Keywords: mitochondria, Bcl-2, cell death, endoplasmic reticulum, PROTEIN-KINASE-C, OUTER MITOCHONDRIAL-MEMBRANE, ELECTRON-TRANSPORT CHAIN, PROGRAMMED CELL-DEATH, ENDOPLASMIC-RETICULUM, PERMEABILITY TRANSITION, CYTOCHROME-C, BCL-2 FAMILY, CA2+ CONCENTRATION, NUCLEAR-ENVELOPE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/167345
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