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Addressing the challenges of multiscale model management in systems biology

Hetherington, J; Bogle, IDL; Saffrey, P; Margoninski, O; Li, L; Rey, MV; Yamaji, S; ... Warner, A; + view all (2007) Addressing the challenges of multiscale model management in systems biology. In: COMPUTERS & CHEMICAL ENGINEERING. (pp. 962 - 979). PERGAMON-ELSEVIER SCIENCE LTD

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Abstract

Mathematical and computational modelling are emerging as important techniques for studying the behaviour of complex biological systems. We argue that two advances are necessary to properly leverage these techniques: firstly, the ability to integrate models developed and executed on separate tools, without the need for substantial translation and secondly, a comprehensive system for storing and man-ageing not only the models themselves but also the parameters and tools used to execute those models and the results they produce. A framework for modelling with these features is described here. We have developed of a suite of XML-based services used for the storing and analysis of models, model parameters and results, and tools for model integration. We present these here, and evaluate their effectiveness using a worked example based on part of the hepatocyte glycogenolysis system. (c) 2006 Elsevier Ltd. All rights reserved.

Type: Proceedings paper
Title: Addressing the challenges of multiscale model management in systems biology
Event: 7th World Congress of Chemical Engineering
Location: Glasgow, SCOTLAND
Dates: 2005-07-10 - 2005-07-14
DOI: 10.1016/j.compchemeng.2006.10.004
Keywords: modelling, systems biology, metadata, middleware, SOFTWARE ENVIRONMENT, OSCILLATIONS, INFORMATION, SIMULATION, GENES, CELLS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Mathematics
UCL > Provost and Vice Provost Offices > VP Research
URI: http://discovery.ucl.ac.uk/id/eprint/166813
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