UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Prognosis of HIV-associated non-Hodgkin lymphoma in patients starting combination antiretroviral therapy

Bohlius, J; Schmidlin, K; Costagliola, D; Fatkenheuer, G; May, M; Caro Murillo, AM; Mocroft, A; ... Egger, M; + view all (2009) Prognosis of HIV-associated non-Hodgkin lymphoma in patients starting combination antiretroviral therapy. AIDS , 23 (15) pp. 2029-2037.

Full text not available from this repository.

Abstract

OBJECTIVE: We examined survival and prognostic factors of patients who developed HIV-associated non-Hodgkin lymphoma (NHL) in the era of combination antiretroviral therapy (cART). DESIGN AND SETTING: Multicohort collaboration of 33 European cohorts. METHODS: We included all cART-naive patients enrolled in cohorts participating in the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) who were aged 16 years or older, started cART at some point after 1 January 1998 and developed NHL after 1 January 1998. Patients had to have a CD4 cell count after 1 January 1998 and one at diagnosis of the NHL. Survival and prognostic factors were estimated using Weibull models, with random effects accounting for heterogeneity between cohorts. RESULTS: Of 67 659 patients who were followed up during 304 940 person-years, 1176 patients were diagnosed with NHL. Eight hundred and forty-seven patients (72%) from 22 cohorts met inclusion criteria. Survival at 1 year was 66% [95% confidence interval (CI) 63-70%] for systemic NHL (n = 763) and 54% (95% CI: 43-65%) for primary brain lymphoma (n = 84). Risk factors for death included low nadir CD4 cell counts and a history of injection drug use. Patients developing NHL on cART had an increased risk of death compared with patients who were cART naive at diagnosis. CONCLUSION: In the era of cART two-thirds of patients diagnosed with HIV-related systemic NHL survive for longer than 1 year after diagnosis. Survival is poorer in patients diagnosed with primary brain lymphoma. More advanced immunodeficiency is the dominant prognostic factor for mortality in patients with HIV-related NHL

Type: Article
Title: Prognosis of HIV-associated non-Hodgkin lymphoma in patients starting combination antiretroviral therapy
Additional information: DA - 20090916 IS - 1473-5571 (Electronic) IS - 0269-9370 (Linking) LA - eng PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't SB - IM SB - X
Keywords: Adolescent, Adult, Antiretroviral Therapy,Highly Active, CD4 Lymphocyte Count, Epidemiologic Methods, Europe, epidemiology, Female, Hiv-1, Humans, Lymphoma,AIDS-Related, drug therapy, immunology, mortality, Lymphoma,Non-Hodgkin, Male, Middle Aged, Prognosis, Treatment Outcome, Young Adult
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
URI: http://discovery.ucl.ac.uk/id/eprint/166592
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item