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Screening of polymeric supports and enzymes for the development of an endo enzyme cleavable linker

Chiva, A; Williams, DE; Tabor, AB; Hailes, HC; (2010) Screening of polymeric supports and enzymes for the development of an endo enzyme cleavable linker. TETRAHEDRON LETT , 51 (20) 2720 - 2723. 10.1016/j.tetlet.2010.03.040.

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Abstract

Several polymeric supports possessing an ester moiety were prepared and a range of enzymes was investigated to hydrolyse the ester linkage and release a signalling group into solution for applications in immunoassays. Pseudomonas lipases were found to most readily cleave the solution-phase analogue and this observation translated well to the corresponding polymeric supports, where the most effective were PEGA resins and the LPOS support PEG-6000. (C) 2010 Elsevier Ltd. All rights reserved.

Type:Article
Title:Screening of polymeric supports and enzymes for the development of an endo enzyme cleavable linker
DOI:10.1016/j.tetlet.2010.03.040
Keywords:Esterases, Lipases, Enzyme cleavable linkers, Solid-phase reactions, LPOS, SOLID SUPPORTS, MOLECULAR-WEIGHT, PHASE, ACCESSIBILITY, CHYMOTRYPSIN, SPECIFICITY, DENDRIMERS, LIBRARIES, ALCOHOLS
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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