Chiva, A and Williams, DE and Tabor, AB and Hailes, HC (2010) Screening of polymeric supports and enzymes for the development of an endo enzyme cleavable linker. TETRAHEDRON LETT , 51 (20) 2720 - 2723. 10.1016/j.tetlet.2010.03.040.
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Abstract
Several polymeric supports possessing an ester moiety were prepared and a range of enzymes was investigated to hydrolyse the ester linkage and release a signalling group into solution for applications in immunoassays. Pseudomonas lipases were found to most readily cleave the solution-phase analogue and this observation translated well to the corresponding polymeric supports, where the most effective were PEGA resins and the LPOS support PEG-6000. (C) 2010 Elsevier Ltd. All rights reserved.
| Type: | Article |
|---|---|
| Title: | Screening of polymeric supports and enzymes for the development of an endo enzyme cleavable linker |
| DOI: | 10.1016/j.tetlet.2010.03.040 |
| Keywords: | Esterases, Lipases, Enzyme cleavable linkers, Solid-phase reactions, LPOS, SOLID SUPPORTS, MOLECULAR-WEIGHT, PHASE, ACCESSIBILITY, CHYMOTRYPSIN, SPECIFICITY, DENDRIMERS, LIBRARIES, ALCOHOLS |
| UCL classification: | UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry |
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