McGuffin, LJ and Street, SA and Bryson, K and Sorensen, SA and Jones, DT (2004) The Genomic Threading Database: a comprehensive resource for structural annotations of the genomes from key organisms. NUCLEIC ACIDS RES , 32 D196 - D199. 10.1093/nar/gkh043.
Abstract
Currently, the Genomic Threading Database (GTD) contains structural assignments for the proteins encoded within the genomes of nine eukaryotes and 101 prokaryotes. Structural annotations are carried out using a modified version of GenTHREADER, a reliable fold recognition method. The GenTHREADER annotation jobs are distributed across multiple clusters of processors using grid technology and the predictions are deposited in a relational database accessible via a web interface at http://bioinf.cs.ucl.ac.uk/GTD. Using this system, up to 84% of proteins encoded within a genome can be confidently assigned to known folds with 72% of the residues aligned. On average in the GTD, 64% of proteins encoded within a genome are confidently assigned to known folds and 58% of the residues are aligned to structures.
| Type: | Article |
|---|---|
| Title: | The Genomic Threading Database: a comprehensive resource for structural annotations of the genomes from key organisms |
| Open access status: | An open access publication |
| DOI: | 10.1093/nar/gkh043 |
| Keywords: | FOLD RECOGNITION, PROTEIN, GENTHREADER, SEQUENCES, SERVER |
| UCL classification: | UCL > School of BEAMS > Faculty of Engineering Science > Computer Science |
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