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The Genomic Threading Database: a comprehensive resource for structural annotations of the genomes from key organisms

McGuffin, LJ; Street, SA; Bryson, K; Sorensen, SA; Jones, DT; (2004) The Genomic Threading Database: a comprehensive resource for structural annotations of the genomes from key organisms. NUCLEIC ACIDS RES , 32 D196 - D199. 10.1093/nar/gkh043. Gold open access

Abstract

Currently, the Genomic Threading Database (GTD) contains structural assignments for the proteins encoded within the genomes of nine eukaryotes and 101 prokaryotes. Structural annotations are carried out using a modified version of GenTHREADER, a reliable fold recognition method. The GenTHREADER annotation jobs are distributed across multiple clusters of processors using grid technology and the predictions are deposited in a relational database accessible via a web interface at http://bioinf.cs.ucl.ac.uk/GTD. Using this system, up to 84% of proteins encoded within a genome can be confidently assigned to known folds with 72% of the residues aligned. On average in the GTD, 64% of proteins encoded within a genome are confidently assigned to known folds and 58% of the residues are aligned to structures.

Type:Article
Title:The Genomic Threading Database: a comprehensive resource for structural annotations of the genomes from key organisms
Open access status:An open access publication
DOI:10.1093/nar/gkh043
Keywords:FOLD RECOGNITION, PROTEIN, GENTHREADER, SEQUENCES, SERVER
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Computer Science

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