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Noradrenergic modulation of space exploration in visual neglect

Malhotra, PA; Parton, AD; Greenwood, R; Husain, M; (2006) Noradrenergic modulation of space exploration in visual neglect. ANN NEUROL , 59 (1) 186 - 190. 10.1002/ana.20701.

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Abstract

Visual neglect after stroke is often associated with a failure to explore contralesional space. Here, we show that guanfacine, a noradrenergic agonist that modulates dorsolateral prefrontal cortex, improves leftward space exploration in selected right-hemisphere patients with neglect. The positive effects of guanfacine were associated with extended ability to maintain attention on task. The results suggest that neuropharmacological targeting of intact frontal areas might be one way to enhance cognitive function after damage to posterior brain regions in selected individuals.

Type:Article
Title:Noradrenergic modulation of space exploration in visual neglect
DOI:10.1002/ana.20701
Keywords:SUSTAINED ATTENTION, UNILATERAL NEGLECT, HEMISPATIAL NEGLECT, MEMORY, GUANFACINE, INSIGHTS, AGONIST, AROUSAL, MONKEYS, SYSTEM
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Psychology and Language Sciences (Division of) > Institute of Cognitive Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
UCL > School of Life and Medical Sciences > Faculty of Life Sciences

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