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Decreased muscle mass and increased central adiposity are independently related to mortality in older men

Wannamethee, SG; Shaper, AG; Lennon, L; Whincup, PH; (2007) Decreased muscle mass and increased central adiposity are independently related to mortality in older men. AM J CLIN NUTR , 86 (5) 1339 - 1346.

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Abstract

Background: Aging is associated with significant changes in body composition. Body mass index (BMI; in kg/m(2)) is not an accurate indicator of overweight and obesity in the elderly. Objective: We examined the relation between other anthropometric indexes of body composition (both muscle mass and body fat) and all-cause mortality in men aged 60-79 y.Design: The study was a prospective study of 4107 men aged 60-79 y with no diagnosis of heart failure and who were followed for a mean period of 6 y, during which time there were 713 deaths.Results: Underweight men (BMI < 18.5) had exceptionally high mortality rates. After the exclusion of these men, increased adiposity [BMI, waist circumference (WC), and waist-to-hip ratio] showed little relation with mortality after adjustment for lifestyle characteristics. Muscle mass [indicated by midarm muscle circumference (MAMC)] was significantly and inversely associated with mortality. After adjustment for MANIC, obesity markers, particularly high WC (> 102 cm) and waist-to-hip ratio (top quartile), were associated with increased mortality. A composite measure of MAMC and WC most effectively predicted mortality. Men with low WC (: 102 cm) and above-median muscle mass showed the lowest mortality risk. Men with WC > 102 cm and above-median muscle mass showed significantly increased mortality [age-adjusted relative risk: 1.36; 95% Cl: 1.07, 1.74), and this increased to 1.55 (95% CI: 1.01, 2.39) in those with WC > 102 and low MANIC.Conclusion: The findings suggest that the combined use of both WC and MAMC provides simple measures of body composition to assess mortality risk in older men.

Type: Article
Title: Decreased muscle mass and increased central adiposity are independently related to mortality in older men
Keywords: body mass index, waist circumference, muscle mass, adiposity, mortality, ALL-CAUSE MORTALITY, BIOELECTRICAL-IMPEDANCE ANALYSIS, CARDIOVASCULAR RISK-FACTORS, SOCIETY-FOR-NUTRITION, WAIST-HIP RATIO, FAT-FREE MASS, BODY-COMPOSITION, ELDERLY-MEN, FOLLOW-UP, OBESITY-SOCIETY
URI: http://discovery.ucl.ac.uk/id/eprint/165053
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