Smithies, K and Smith, MEB and Kaulmann, U and Galman, JL and Ward, JM and Hailes, HC (2009) Stereoselectivity of an omega-transaminase-mediated amination of 1,3-dihydroxy-1-phenylpropane-2-one. TETRAHEDRON-ASYMMETR , 20 (5) 570 - 574. 10.1016/j.tetasy.2009.03.012.
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Abstract
The stereoselectivity of a recently isolated omega-transaminase from Chromobacterium violaceum in the amination of 1,3-dihydroxy-1-phenylpropan-2-one has been determined. The enzyme is not enantioselective towards a racemic mixture of 1,3-dihydroxy-1-phenylpropan-2-one but is highly stereoselective forming (2S)-2-amino-1-phenyl-1,3-propanediols in >99% ee. (C) 2009 Elsevier Ltd. All rights reserved.
| Type: | Article |
|---|---|
| Title: | Stereoselectivity of an omega-transaminase-mediated amination of 1,3-dihydroxy-1-phenylpropane-2-one |
| DOI: | 10.1016/j.tetasy.2009.03.012 |
| Keywords: | ASYMMETRIC-SYNTHESIS, CHIRAL AMINES, SUBSTRATE-SPECIFICITY, ESCHERICHIA-COLI, TRANSKETOLASE, DIHYDROXYLATION, LIGAND |
| UCL classification: | UCL > School of BEAMS > Faculty of Engineering Science > Biochemical Engineering UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry |
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