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Stereoselectivity of an omega-transaminase-mediated amination of 1,3-dihydroxy-1-phenylpropane-2-one

Smithies, K; Smith, MEB; Kaulmann, U; Galman, JL; Ward, JM; Hailes, HC; (2009) Stereoselectivity of an omega-transaminase-mediated amination of 1,3-dihydroxy-1-phenylpropane-2-one. TETRAHEDRON-ASYMMETR , 20 (5) 570 - 574. 10.1016/j.tetasy.2009.03.012.

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Abstract

The stereoselectivity of a recently isolated omega-transaminase from Chromobacterium violaceum in the amination of 1,3-dihydroxy-1-phenylpropan-2-one has been determined. The enzyme is not enantioselective towards a racemic mixture of 1,3-dihydroxy-1-phenylpropan-2-one but is highly stereoselective forming (2S)-2-amino-1-phenyl-1,3-propanediols in >99% ee. (C) 2009 Elsevier Ltd. All rights reserved.

Type:Article
Title:Stereoselectivity of an omega-transaminase-mediated amination of 1,3-dihydroxy-1-phenylpropane-2-one
DOI:10.1016/j.tetasy.2009.03.012
Keywords:ASYMMETRIC-SYNTHESIS, CHIRAL AMINES, SUBSTRATE-SPECIFICITY, ESCHERICHIA-COLI, TRANSKETOLASE, DIHYDROXYLATION, LIGAND
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Biochemical Engineering
UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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