Stereoselectivity of an omega-transaminase-mediated amination of 1,3-dihydroxy-1-phenylpropane-2-one.
570 - 574.
The stereoselectivity of a recently isolated omega-transaminase from Chromobacterium violaceum in the amination of 1,3-dihydroxy-1-phenylpropan-2-one has been determined. The enzyme is not enantioselective towards a racemic mixture of 1,3-dihydroxy-1-phenylpropan-2-one but is highly stereoselective forming (2S)-2-amino-1-phenyl-1,3-propanediols in >99% ee. (C) 2009 Elsevier Ltd. All rights reserved.
|Title:||Stereoselectivity of an omega-transaminase-mediated amination of 1,3-dihydroxy-1-phenylpropane-2-one|
|Keywords:||ASYMMETRIC-SYNTHESIS, CHIRAL AMINES, SUBSTRATE-SPECIFICITY, ESCHERICHIA-COLI, TRANSKETOLASE, DIHYDROXYLATION, LIGAND|
|UCL classification:||UCL > School of BEAMS > Faculty of Engineering Science
UCL > School of BEAMS > Faculty of Engineering Science > Biochemical Engineering
UCL > School of BEAMS > Faculty of Maths and Physical Sciences
UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry
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