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8-OH-DPAT-INDUCED INHIBITION OF RENAL SYMPATHETIC-NERVE ACTIVITY AND SEROTONIN NEURONAL FIRING

RAMAGE, AG; CLEMENT, ME; MCCALL, RB; (1992) 8-OH-DPAT-INDUCED INHIBITION OF RENAL SYMPATHETIC-NERVE ACTIVITY AND SEROTONIN NEURONAL FIRING. EUR J PHARMACOL , 219 (1) 165 - 167.

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Abstract

The effects of the 5-HT1A receptor 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) administered i.v. on medullary 5-HT neuronal firing and renal sympathetic nerve activity were determined in spontaneously breathing anaesthetized cats. Low doses of 8-OH-DPAT (1-3-mu-g/kg) caused a similar reduction in 5-HT neuronal firing and renal nerve activity while high doses (10-30-mu-g/kg) completely inhibited neuronal firing but caused only 80% inhibition of renal nerve activity. These data are discussed in relationship to the mechanism of sympatholytic action of 8-OH-DPAT and the serotonergic regulation of sympathetic nerve activity.

Type: Article
Title: 8-OH-DPAT-INDUCED INHIBITION OF RENAL SYMPATHETIC-NERVE ACTIVITY AND SEROTONIN NEURONAL FIRING
Keywords: 5-HT1A RECEPTORS, 8-OH-DPAT (8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN), RENAL NERVE ACTIVITY, MEDULLARY 5-HT NEURONS, ANESTHETIZED CATS, PREGANGLIONIC NEURONS, RECEPTOR AGONISTS, PUTATIVE 5-HT1A, 8-OH DPAT, MECHANISM, SITE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: http://discovery.ucl.ac.uk/id/eprint/164495
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