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An investigation of glucose uptake in relation to steroidogenesis in rat testis and tumour Leydig cells

Amrolia, P; Sullivan, MH; Garside, D; Baldwin, SA; Cooke, BA; (1988) An investigation of glucose uptake in relation to steroidogenesis in rat testis and tumour Leydig cells. Biochem J , 249 (3) pp. 925-928.

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Abstract

The mechanisms of the requirement of glucose for steroidogenesis were investigated by monitoring the uptake of the glucose analogue 2-deoxy-D-glucose by rat testis and tumour Leydig cells. The characteristics of glucose transport in both of these cell types were found to resemble those of the facilitated-diffusion systems for glucose found in most other mammalian cells. The Leydig cells took up 2-deoxy-D-glucose but not L-glucose, and the uptake was inhibited by both cytochalasin B and forskolin. In the presence of luteinizing hormone, the rate of 2-deoxy-D-glucose uptake by both cell types was increased by approx. 50%. In addition to D-glucose, it was shown that the Leydig cells could also utilize 3-hydroxybutyrate or glutamine to maintain steroidogenesis

Type: Article
Title: An investigation of glucose uptake in relation to steroidogenesis in rat testis and tumour Leydig cells
Additional information: DA - 19880503IS - 0264-6021 (Print)LA - engPT - In VitroPT - Journal ArticlePT - Research Support, Non-U.S. Gov'tRN - 0 (Deoxy Sugars)RN - 14930-96-2 (Cytochalasin B)RN - 154-17-6 (Deoxyglucose)RN - 362-74-3 (Bucladesine)RN - 58-22-0 (Testosterone)RN - 66428-89-5 (Forskolin)RN - 9002-67-9 (Luteinizing Hormone)SB - IM
Keywords: Animals, Biological Transport, biosynthesis, Bucladesine, Cytochalasin B, Deoxy Sugars, Deoxyglucose, drug effects, Forskolin, Leydig Cells, Luteinizing Hormone, Male, metabolism, pharmacokinetics, pharmacology, Rats, Testicular Neoplasms, Testosterone
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health
URI: http://discovery.ucl.ac.uk/id/eprint/163378
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