Galman, JL; Hailes, HC; (2009) Application of a modified Mosher's method for the determination of enantiomeric ratio and absolute configuration at C-3 of chiral 1,3-dihydroxy ketones. TETRAHEDRON-ASYMMETR , 20 (15) 1828 - 1831. 10.1016/j.tetasy.2009.07.023.
Full text not available from this repository.
Abstract
The enantiomeric ratio and absolute configuration of products of the transketolase reaction are typically determined by comparison of the specific rotation or derivatisation and HPLC or GC. A Mosher's ester method has been developed via ester formation at the primary alcohol C-1 which can be used to determine the stereoselectivity of the reaction, as well as the absolute configuration of the product at C-3. (c) 2009 Elsevier Ltd. All rights reserved.
| Type: | Article |
|---|---|
| Title: | Application of a modified Mosher's method for the determination of enantiomeric ratio and absolute configuration at C-3 of chiral 1,3-dihydroxy ketones |
| DOI: | 10.1016/j.tetasy.2009.07.023 |
| Keywords: | ESCHERICHIA-COLI, ALPHA,ALPHA'-DIHYDROXY KETONES, TRANSKETOLASE ACTIVITY, SUBSTRATE-SPECIFICITY, DIRECTED EVOLUTION, ALCOHOLS, STEREOCHEMISTRY, SPECTROSCOPY, TRANSAMINASE, ALDEHYDES |
| UCL classification: | UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry |
Archive Staff Only: edit this record