Galman, JL and Hailes, HC (2009) Application of a modified Mosher's method for the determination of enantiomeric ratio and absolute configuration at C-3 of chiral 1,3-dihydroxy ketones. TETRAHEDRON-ASYMMETR , 20 (15) 1828 - 1831. 10.1016/j.tetasy.2009.07.023.
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Abstract
The enantiomeric ratio and absolute configuration of products of the transketolase reaction are typically determined by comparison of the specific rotation or derivatisation and HPLC or GC. A Mosher's ester method has been developed via ester formation at the primary alcohol C-1 which can be used to determine the stereoselectivity of the reaction, as well as the absolute configuration of the product at C-3. (c) 2009 Elsevier Ltd. All rights reserved.
| Type: | Article |
|---|---|
| Title: | Application of a modified Mosher's method for the determination of enantiomeric ratio and absolute configuration at C-3 of chiral 1,3-dihydroxy ketones |
| DOI: | 10.1016/j.tetasy.2009.07.023 |
| Keywords: | ESCHERICHIA-COLI, ALPHA,ALPHA'-DIHYDROXY KETONES, TRANSKETOLASE ACTIVITY, SUBSTRATE-SPECIFICITY, DIRECTED EVOLUTION, ALCOHOLS, STEREOCHEMISTRY, SPECTROSCOPY, TRANSAMINASE, ALDEHYDES |
| UCL classification: | UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry |
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