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Application of a modified Mosher's method for the determination of enantiomeric ratio and absolute configuration at C-3 of chiral 1,3-dihydroxy ketones

Galman, JL; Hailes, HC; (2009) Application of a modified Mosher's method for the determination of enantiomeric ratio and absolute configuration at C-3 of chiral 1,3-dihydroxy ketones. TETRAHEDRON-ASYMMETR , 20 (15) 1828 - 1831. 10.1016/j.tetasy.2009.07.023.

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Abstract

The enantiomeric ratio and absolute configuration of products of the transketolase reaction are typically determined by comparison of the specific rotation or derivatisation and HPLC or GC. A Mosher's ester method has been developed via ester formation at the primary alcohol C-1 which can be used to determine the stereoselectivity of the reaction, as well as the absolute configuration of the product at C-3. (c) 2009 Elsevier Ltd. All rights reserved.

Type:Article
Title:Application of a modified Mosher's method for the determination of enantiomeric ratio and absolute configuration at C-3 of chiral 1,3-dihydroxy ketones
DOI:10.1016/j.tetasy.2009.07.023
Keywords:ESCHERICHIA-COLI, ALPHA,ALPHA'-DIHYDROXY KETONES, TRANSKETOLASE ACTIVITY, SUBSTRATE-SPECIFICITY, DIRECTED EVOLUTION, ALCOHOLS, STEREOCHEMISTRY, SPECTROSCOPY, TRANSAMINASE, ALDEHYDES
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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