UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Application of a modified Mosher's method for the determination of enantiomeric ratio and absolute configuration at C-3 of chiral 1,3-dihydroxy ketones

Galman, JL; Hailes, HC; (2009) Application of a modified Mosher's method for the determination of enantiomeric ratio and absolute configuration at C-3 of chiral 1,3-dihydroxy ketones. TETRAHEDRON-ASYMMETR , 20 (15) 1828 - 1831. 10.1016/j.tetasy.2009.07.023.

Full text not available from this repository.

Abstract

The enantiomeric ratio and absolute configuration of products of the transketolase reaction are typically determined by comparison of the specific rotation or derivatisation and HPLC or GC. A Mosher's ester method has been developed via ester formation at the primary alcohol C-1 which can be used to determine the stereoselectivity of the reaction, as well as the absolute configuration of the product at C-3. (c) 2009 Elsevier Ltd. All rights reserved.

Type: Article
Title: Application of a modified Mosher's method for the determination of enantiomeric ratio and absolute configuration at C-3 of chiral 1,3-dihydroxy ketones
DOI: 10.1016/j.tetasy.2009.07.023
Keywords: ESCHERICHIA-COLI, ALPHA,ALPHA'-DIHYDROXY KETONES, TRANSKETOLASE ACTIVITY, SUBSTRATE-SPECIFICITY, DIRECTED EVOLUTION, ALCOHOLS, STEREOCHEMISTRY, SPECTROSCOPY, TRANSAMINASE, ALDEHYDES
UCL classification: UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry
URI: http://discovery.ucl.ac.uk/id/eprint/163177
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item