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Attention deficits following ADEM ameliorated by guanfacine

Singh-Curry, V; Malhotra, P; Farmer, SF; Husain, M; (2011) Attention deficits following ADEM ameliorated by guanfacine. J NEUROL NEUROSUR PS , 82 (6) 688 - 690. 10.1136/jnnp.2009.195792. Gold open access

Abstract

The authors report here the case of a patient with severe deficits in arousal and sustained attention, associated with hemispatial neglect. These impairments were secondary to acute disseminated encephalomyelitis, with bilateral involvement of the medial nuclei and pulvinar of the thalamus. Treatment with the noradrenergic agonist guanfacine, previously used for attention deficits in attention deficit/hyperactivity disorder and stroke, was associated with a significant amelioration of both the spatial and sustained attention impairments in neglect. Guanfacine may prove to be a useful tool in the treatment of disorders of attention associated with neurological conditions.

Type: Article
Title: Attention deficits following ADEM ameliorated by guanfacine
Open access status: An open access publication
DOI: 10.1136/jnnp.2009.195792
Publisher version: http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC30901...
Keywords: ACUTE DISSEMINATED ENCEPHALOMYELITIS, VISUAL NEGLECT, SPATIAL NEGLECT, DISORDER, THALAMUS, NUCLEUS, ANATOMY
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Psychology and Language Sciences (Division of) > Institute of Cognitive Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/163051
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