UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Dissociable human perirhinal, hippocampal, and parahippocampal roles during verbal encoding

Strange, BA; Otten, LJ; Josephs, O; Rugg, MD; Dolan, RJ; (2002) Dissociable human perirhinal, hippocampal, and parahippocampal roles during verbal encoding. J NEUROSCI , 22 (2) 523 - 528.

Full text not available from this repository.

Abstract

The precise contribution of perirhinal cortex to human episodic memory is uncertain. Human intracranial recordings highlight a role in successful episodic memory encoding, but encoding-related perirhinal activation has not been observed with functional imaging. By adapting functional magnetic resonance imaging scanning parameters to maximize sensitivity to medial temporal lobe activity, we demonstrate that left perirhinal and hippocampal responses during word list encoding are greater for subsequently recalled than forgotten words. Although perirhinal responses predict memory for all words, successful encoding of initial words in a list, demonstrating a primacy effect, is associated with parahippocampal and anterior hippocampal activation. We conclude that perirhinal cortex and hippocampus participate in successful memory encoding. Encoding-related parahippocampal and anterior hippocampal responses for initial, remembered words most likely reflects enhanced attentional orienting to these positionally distinctive items.

Type: Article
Title: Dissociable human perirhinal, hippocampal, and parahippocampal roles during verbal encoding
Keywords: perirhinal cortex, hippocampus, parahippocampal cortex, fMRI, episodic memory encoding, subsequent memory effect, primacy effect, MEDIAL TEMPORAL-LOBE, RECOGNITION MEMORY, BRAIN ACTIVITY, TERM-MEMORY, PET, ACTIVATIONS, RETRIEVAL, AMNESIA, RECALL, FMRI
URI: http://discovery.ucl.ac.uk/id/eprint/163038
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item