UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Spatial accuracy of 3D reconstructed radioluminographs of serial tissue sections and resultant absorbed dose estimates

Petrie, IA; Flynn, AA; Pedley, RB; Green, AJ; El-Emir, E; Dearling, JLJ; Boxer, GM; ... Begent, RHJ; + view all (2002) Spatial accuracy of 3D reconstructed radioluminographs of serial tissue sections and resultant absorbed dose estimates. PHYS MED BIOL , 47 (20) 3651 - 3661.

Full text not available from this repository.

Abstract

Many agents using tumour-associated characteristics are deposited heterogeneously within tumour tissue. Consequently, tumour heterogeneity should be addressed when obtaining information on tumour biology or relating absorbed radiation dose to biological effect. We present a technique that enables radioluminographs of serial tumour sections to be reconstructed using automated computerized techniques, resulting in a three-dimensional map of the dose-rate distribution of a radiolabelled antibody. The purpose of this study is to assess the reconstruction accuracy. Furthermore, we estimate the potential error resulting from registration misalignment, for a range of beta-emitting radionuclides. We compare the actual dose-rate distribution with that obtained from the same activity distribution but with manually defined translational and rotational shifts. As expected, the error produced with the short-range C-14 is much larger than that for the longer range Y-90, similarly values for the medium range I-131 are between the two. Thus, the impact of registration inaccuracies is greater for short-range sources.

Type: Article
Title: Spatial accuracy of 3D reconstructed radioluminographs of serial tissue sections and resultant absorbed dose estimates
Keywords: CARCINOEMBRYONIC ANTIGEN, ANTIBODY THERAPY, TUMOR, RADIOIMMUNOTHERAPY, AUTORADIOGRAPHY, DOSIMETRY, IMAGES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/162516
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item