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Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis

Pooran, A; Booth, H; Miller, RF; Scott, G; Badri, M; Huggett, JF; Rook, G; ... Dheda, K; + view all (2010) Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis. BMC Pulmonary Medicine , 10 , Article 7. 10.1186/1471-2466-10-7. Green open access

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Abstract

Previous health economic studies recommend either a dual screening strategy [tuberculin skin test (TST) followed by interferon-gamma-release assay (IGRA)] or a single one [IGRA only] for latent tuberculosis infection (LTBI), the former largely based on claims that it is more cost-effective. We sought to examine that conclusion through the use of a model that accounts for the additional costs of adverse drug reactions and directly compares two commercially available versions of the IGRA: the Quantiferon-TB-Gold-In-Tube (QFT-GIT) and T-SPOT.TB.

Type: Article
Title: Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1471-2466-10-7
Publisher version: http://dx.doi.org/10.1186/1471-2466-10-7
Language: English
Additional information: © 2010 Pooran et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC2837635
Keywords: Contact Tracing, Cost-Benefit Analysis, Decision Trees, Enzyme-Linked Immunosorbent Assay, Great Britain, Health Care Costs, Humans, Incidence, Interferon-gamma, Mass Screening, Prevalence, Sensitivity and Specificity, Tuberculin Test, Tuberculosis, Pulmonary
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/162388
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