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Responses to human rhinovirus in CD45 T cell subsets isolated from tonsil

Wilamasundera, S; Katz, DR; Chain, BM; (1998) Responses to human rhinovirus in CD45 T cell subsets isolated from tonsil. EUR J IMMUNOL , 28 (12) 4374 - 4381.

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Abstract

Isotypes of CD45 have been used extensively as markers of memory and naive populations of T cells in peripheral blood. in this study, T cells were isolated from human tonsil and their proliferative response against human rhinovirus was measured. Unexpectedly, equivalent responses were found among the CD4(+)CD45RA(+) and CD4(+)CD45RO(+) populations of T cells. This response requires MHC class II-positive antigen-presenting cells. The time course of the T cell response in vitro was that of a classical recall response, and no proliferative response to the virus could be detected in human cord brood. These results suggest that tonsils contain a significant population of CD45RA(+) memory cells. The presence of this population may reflect ongoing stimulation with this common infectious agent, and the anatomical location of the T cells within the major lymphoid organ draining the naso-pharyngeal epithelial surface.

Type: Article
Title: Responses to human rhinovirus in CD45 T cell subsets isolated from tonsil
Keywords: human rhinovirus, CD45 isoform, T cell response, tonsil, memory response, PROLIFERATIVE RESPONSES, MEMORY, ANTIGEN, UCHL1, EXPRESSION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: http://discovery.ucl.ac.uk/id/eprint/158512
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