Scully, C and Porter, SR and Di Alberti, L and Jalal, M and Maitland, N (1998) Detection of Epstein-Barr virus in oral scrapes in HIV infection, in hairy leukoplakia, and in healthy non-HIV-infected people. J ORAL PATHOL MED , 27 (10) 480 - 482.
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Epstein-Barr virus (EBV) has been implicated in the pathogenesis of oral hairy leukoplalcia (OHL). EBV is normally detected by lesional biopsy. The objectives of this study were to examine oral scrapes containing squamous epithelial cells (squames) from HIV-infected people with and without clinical lesions of OWL, and from healthy non-HIV-infected controls, for EBV-DNA by the polymerase chain reaction (PCR). EBV-DNA was detected in 65% of HIV-infected people and 20% of healthy HIV-negative controls but in HN-infected individuals it was found as frequently in those without OHL as in those with. Moreover, EBV-DNA was not detected in all HIV-infected individuals, nor in all OHL. The results suggest that the presence or absence of detectable EBV-DNA in oral scrapes, though a guide, cannot be regarded as absolutely reliable in the diagnosis or exclusion of OHL.
|Title:||Detection of Epstein-Barr virus in oral scrapes in HIV infection, in hairy leukoplakia, and in healthy non-HIV-infected people|
|Keywords:||cytology, Epstein-Barr virus, hairy leukoplakia, HIV, POLYMERASE CHAIN-REACTION, EXFOLIATIVE CYTOLOGY, DIAGNOSIS, HYBRIDIZATION, BIOPSIES, TONGUE, DNA, TISSUE, AIDS|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute|
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