%PDF-1.3
%
1 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
22 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
18 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
7 0 obj
<>>>/BBox[0 0 612 792]/Length 54>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
9 0 obj
<>>>/BBox[0 0 612 792]/Length 140>>stream
xͱ0OqFl{*Ln8RLiI^ONf&@8 u|4kaWO]FU*YRw֥y\,l̐JP!cX&?+/hnfE*
endstream
endobj
15 0 obj
<>>>/BBox[0 0 612 792]/Length 54>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
16 0 obj
<>>>/BBox[0 0 612 792]/Length 55>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
21 0 obj
<>>>/BBox[0 0 612 792]/Length 140>>stream
xͱ0OqFl{*Ln8RLiI^ONf&@8 u|4kaWO]FU*YRw֥y\,l̐JP!cX&?+/hnfE*
endstream
endobj
13 0 obj
<>>>/BBox[0 0 612 792]/Length 140>>stream
xͱ0OqFl{*Ln8RLiI^ONf&@8 u|4kaWO]FU*YRw֥y\,l̐JP!cX&?+/hnfE*
endstream
endobj
23 0 obj
<>>>/BBox[0 0 612 792]/Length 54>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
3 0 obj
<>>>/BBox[0 0 612 792]/Length 54>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
4 0 obj
<>>>/BBox[0 0 612 792]/Length 55>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
11 0 obj
<>>>/BBox[0 0 612 792]/Length 54>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
10 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
29 0 obj
<>>>/BBox[0 0 612 792]/Length 140>>stream
xͱ0OqFl{*Ln8RLiI^ONf&@8 u|4kaWO]FU*YRw֥y\,l̐JP!cX&?+/hnfE*
endstream
endobj
14 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
19 0 obj
<>>>/BBox[0 0 612 792]/Length 54>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
17 0 obj
<>>>/BBox[0 0 612 792]/Length 140>>stream
xͱ0OqFl{*Ln8RLiI^ONf&@8 u|4kaWO]FU*YRw֥y\,l̐JP!cX&?+/hnfE*
endstream
endobj
27 0 obj
<>>>/BBox[0 0 612 792]/Length 54>>stream
xs
w3T04PI2P0T5T R
Ɩf
!\!Y\ !p )P
endstream
endobj
25 0 obj
<>>>/BBox[0 0 612 792]/Length 140>>stream
xͱ0OqFl{*Ln8RLiI^ONf&@8 u|4kaWO]FU*YRw֥y\,l̐JP!cX&?+/hnfE*
endstream
endobj
6 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
20 0 obj
<>>>/BBox[0 0 612 792]/Length 55>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
28 0 obj
<>>>/BBox[0 0 612 792]/Length 55>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
12 0 obj
<>>>/BBox[0 0 612 792]/Length 55>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
5 0 obj
<>>>/BBox[0 0 612 792]/Length 140>>stream
xͱ0OqFl{*Ln8RLiI^ONf&@8 u|4kaWO]FU*YRw֥y\,l̐JP!cX&?+/hnfE*
endstream
endobj
8 0 obj
<>>>/BBox[0 0 612 792]/Length 55>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
24 0 obj
<>>>/BBox[0 0 612 792]/Length 55>>stream
xs
w3T04PI2P0T5T0P02S04S @$P5 )1
endstream
endobj
26 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T04PI2P0T5T0 q-Br44C@B 9 s
(P
endstream
endobj
31 0 obj
<>stream
Acrobat Distiller 8.1.0 (Windows); modified using iText 4.2.0 by 1T3XT
Arbortext Advanced Print Publisher 9.0.114/W
2017-08-14T03:35:14-07:00
2017-08-09T21:04:51+05:30
application/pdf
CAN-2017-0024-ver9-Hindocha_2P 217..223
uuid:5b39b729-0ebb-4988-a092-fe6638aa2bfd
uuid:fee0290b-7d50-4268-92f7-cddca0702bc4
endstream
endobj
32 0 obj
<>stream
x+ |
endstream
endobj
33 0 obj
<>stream
xS**T0T0 BiUn)sT
endstream
endobj
34 0 obj
<>stream
x+ |
endstream
endobj
35 0 obj
<>stream
xS**T0T0 BiU9C\
endstream
endobj
36 0 obj
<>stream
x+ |
endstream
endobj
37 0 obj
<>stream
xS**T0T0 Bih]9K\ x
endstream
endobj
38 0 obj
<>stream
x+ |
endstream
endobj
39 0 obj
<>stream
xS**T0T0 BiUn)cT h
endstream
endobj
40 0 obj
<>stream
x+ |
endstream
endobj
41 0 obj
<>stream
xS**T0T0 Bih] 9S\ h
endstream
endobj
42 0 obj
<>stream
x+ |
endstream
endobj
43 0 obj
<>stream
xS**T0T0 Bid]9c\ d
endstream
endobj
44 0 obj
<>stream
x+ |
endstream
endobj
45 0 obj
<>stream
xS**T0T0 Bid]9s\ Jt
endstream
endobj
47 0 obj
<>stream
/GS1 gs
BT
/F7 1 Tf
10.959 0 0 10.959 62.022 697.8896 Tm
0 0 0 rg
.0129 Tc
0 Tw
[(are)-321.2(o).8(ften)-315.2(u)-5.1(n).4(known.)-317.5(Moreover,)-317.5(t)-.7(h)-4.5(e)-316(quan)-4.8(tity)-320.6(of)-316.9(u)-5.1(s)-.7(e)-316(i)-1.3(s)]TJ
0 -1.1847 TD
0 Tc
[(lik)16.1(ely)-267.6(to)-274(be)-268.7(di)9.2(ffe)15.1(re)9.2(nt)-274.4(ac)9.8(ro)10.4(ss)-270.4(typ)12.6(es)-270.2(of)-274.7(us)9.7(er)14.4(s,)-276.8(wh)13(er)9.2(e)-277.2(r)0(e)9.2(c)0(r)9.2(e)0(-)]TJ
0 -1.1795 TD
[(ati)16.1(on)11.5(al)-311.4(us)9.7(er)9.2(s)-313.7(a)0(r)9.5(e)-313.4(li)13.4(ke)10(ly)-311.1(to)-305.1(us)9.7(e)-313.4(les)10.9(s)-313.7(c)0(a)9.8(n)0(n)11.1(a)0(b)11(i)0(s)13.6(,)-314.8(an)10.6(d)-318.1(t)0(h)10.5(e)0(r)14.4(e)0(-)]TJ
0 -1.1847 TD
[(fo)9.8(re)-461.6(po)11.2(ten)12.3(tia)16.1(lly)-459.5(m)10.2(o)0(r)10.4(e)-468.6(to)10.5(ba)11(cc)9.5(o,)-466.7(th)15.6(an)-465.3(da)10.3(ily)-459.8(us)9.7(er)9.2(s.)-463(Th)12.1(e)]TJ
0 -1.1795 TD
[(ab)11(se)9.2(nc)10.3(e)-251.3(o)0(f)-248.8(a)-256.2(st)14.2(an)10.6(dar)12.2(di)9.2(ze)9.5(d)-250.8()47.3(c)13.2(ann)13.6(ab)11(is)-250.3(un)10.8(it)60.9()-252.8(a)0(n)10.6(d)-256(me)12.3(th)10.5(od)11.2(-)]TJ
0 -1.1847 TD
[(olo)13.6(gi)14.4(ca)9.8(l)-277.7(d)0(i)9.2(ffe)15.1(re)9.2(nc)10.3(es)-270.2(be)10.7(tw)11.6(ee)9.5(n)-276.4(stu)11.7(di)9.2(es)-270.2(hi)9.8(nd)10.8(er)-270.2(di)9.2(re)9.2(ct)-270.1(co)10.7(m-)]TJ
0 -1.1795 TD
[(pa)10.3(ris)15.4(on)11.5(s)-236.1(r)0(e)9.2(g)0(a)10.4(r)0(d)9.7(i)0(n)9.5(g)-230(th)10.5(e)-230.6(eff)15.1(ec)9.5(ts)-229(of)-228.1(ca)9.8(nn)11.1(ab)11(is.)]TJ
8.2191 0 0 7.3052 241.9086 625.0392 Tm
(25)Tj
10.959 0 0 10.959 256.422 620.1636 Tm
[(Mor)16(eo)10.7(ve)10.1(r,)]TJ
-17.7388 -1.1795 TD
[(th)10.5(e)-313.4(r)0(o)10.4(l)0(e)-306.6(o)0(f)]TJ
/F10 1 Tf
4.4748 0 TD
[(fre)9.9(qu)11.6(en)10.3(cy)-305.4(of)-307(us)10.4(e)]TJ
/F7 1 Tf
6.6579 0 TD
[(is)-307.2(of)9.8(ten)-303.3(ov)11.3(er)9.2(em)12.3(pha)13.6(siz)15.7(ed)-310.7(at)]TJ
-11.1327 -1.1847 TD
[(th)10.5(e)-303.1(e)0(x)9.7(p)0(e)10(n)0(s)10(e)-297.9(of)-295.4(qu)10.9(an)10.6(tit)15.6(y)-302.5(\(e.)14.8(g.,)-290.7(am)12.6(oun)14.2(t)-298.1(o)0(f)-295.4(c)0(a)9.8(nna)13.6(bis)-288.3(us)9.7(ed)]TJ
0 -1.1795 TD
[(pe)10(r)-334.4(d)0(a)10.3(y)0(,)-322.4(p)0(e)10(r)-334.4(joi)16.7(nt)10.1(,)-330.4(o)0(r)-325.8(joi)16.7(nt)10.1(s)-334.4(p)0(e)10(r)-329.2(gr)9.8(am)12.6(\),)-328.8(wh)13(ich)-324.3(is)-322.7(als)11.2(o)-327.7(a)]TJ
0 -1.1847 TD
[(pr)9.7(ed)10(ict)15.8(or)-289.6(of)-290.2(pr)9.7(ob)11.9(lem)14(ati)16.1(c)-297.9(u)0(s)9.7(e)0(.)]TJ
8.2191 0 0 7.3052 188.2204 573.2219 Tm
[(1,6)17.2(8)]TJ
10.959 0 0 10.959 72.9637 555.4203 Tm
[(Another)-259.6(major)-254.7(issue)-259.1(is)-255.4(that)-254.1(worldwide,)-259.1(cannabis)-254.6(use)]TJ
-.9984 -1.1847 TD
[(is)-286.5(strongly)-286(associated)-288.1(with)-288.9(tobacco)-281.3(use.)]TJ
8.2191 0 0 7.3052 233.7448 547.3132 Tm
(9,10)Tj
10.959 0 0 10.959 250.5259 542.4377 Tm
(Particularly)Tj
-17.2008 -1.1795 TD
[(in)-259.5(Europe,)-257.4(cannabis)-254.6(is)-260.6(most)-256.8(commonly)-253.1(combined)-256.4(with)]TJ
0 -1.1847 TD
[(tobacco)-281.3(into)-280.1(joints)-281.7(as)-285.4(the)-282.3(primary)-282.1(consumption)-280.1(meth-)]TJ
0 -1.1795 TD
(od.)Tj
8.2191 0 0 7.3052 75.5716 508.4786 Tm
(11)Tj
10.959 0 0 10.959 86.4566 503.603 Tm
[(In)-269.3(Europe,)-273()42.1(joints)45.7()-268.3(typically)-270.3(contain)-272.5(a)-271.7(mixture)-272.3(of)]TJ
-2.2296 -1.1795 TD
[(cannabis)-239.1(and)-245.4(tobacco)-234.7(\(and)-243.8(are)-241.8(interchangeably)-237.8(also)-238.9(re-)]TJ
0 -1.1847 TD
[(ferred)-381.2(to)-377.5(as)-378.5()42.1(spliffs)44.5(\).)-379.8(Hereafter,)-377(we)-381.4(refer)-378.7(to)-377.5(joints)-380(as)]TJ
0 -1.1795 TD
[(a)-411.4(mixture)-412(of)-409.2(cannabis)-409.8(and)-410.9(tobacco;)-409.9(however,)-413.7(we)-407.2(ac-)]TJ
0 -1.1847 TD
[(knowledge)-440.6(that)-440.4(in)-440.6(the)-442.6(United)-439.4(States,)-441.7(joints)-442(typically)]TJ
0 -1.1795 TD
[(do)-278.5(not)-276.2(contain)-272.5(tobacco.)]TJ
8.2191 0 0 7.3052 165.8834 443.7353 Tm
(12)Tj
10.959 0 0 10.959 176.7684 438.8597 Tm
[(Adding)-278.3(nicotine)-276.6(to)-274(cannabis)]TJ
-10.4705 -1.1847 TD
[(may)-258.8(modify)-262.9(its)-263.8(dose)-258.9(by)-262.9(increasing)-257.5(the)-261.6(amount)-260.9(of)-259.2(THC)]TJ
0 -1.1795 TD
[(released)-236.5(by)-231.8(almost)-232(half)]TJ
8.2191 0 0 7.3052 160.8377 417.8267 Tm
(13)Tj
10.959 0 0 10.959 171.2692 412.9511 Tm
[(as)-238.8(well)-233.2(as)-233.6(affecting)-235.1(the)-235.7(subjec-)]TJ
-9.9687 -1.1847 TD
[(tive)-219.4(ex)20.1(pe)20.3(ri)18.7(en)20.6(ce)]TJ
8.2191 0 0 7.3052 125.4614 404.844 Tm
[(14)19.9(,)18(1)0(5)]TJ
10.959 0 0 10.959 144.907 399.9684 Tm
[(an)21(d)-214.6(c)12.5(og)21.6(ni)19.8(ti)18.8(ve)-202(e)12.5(f)0(f)18.1(e)12.5(ct)19.6(s)-210.2(o)0(f)-202.3(c)0(a)20.1(n)0(n)21.5(a)0(b)16.2(i)11.7(s)12.2(.)]TJ
8.2191 0 0 7.3052 284.0314 404.844 Tm
-.0179 Tc
[(15)-17.9(,16)]TJ
10.959 0 0 10.959 62.022 387.0424 Tm
0 Tc
[(Co)23.1(m)10.2(b)0(i)20.2(n)0(i)19.8(n)0(g)-252.9(c)12.5(an)15.8(n)13.3(a)0(b)21.3(i)0(s)-255.4(a)12.8(nd)-253(t)12.3(o)0(b)22.3(a)0(c)20.1(c)0(o)-253.1(i)11.7(n)-260.8(j)0(o)20.6(i)0(n)19.8(t)0(s)-254.8(t)12.3(hu)21.5(s)-262(e)0(x)20.1(p)0(o)21.6(s)0(e)19.5(s)]TJ
T*
[(us)20.1(er)19.5(s)-246.4(t)12.3(o)-244.9(t)12.3(ob)22.3(ac)20.1(co)21(,)-247.6(p)13(ot)20.8(en)15.5(t)12.3(i)11.7(al)19.7(ly)-233.5(l)12(e)0(a)14.9(d)13(i)11.7(n)0(g)-237.4(t)12.3(o)-244.9(a)-240.7(vu)15.8(l)12(n)0(e)20.6(r)0(a)19.8(b)0(i)20.2(l)12(it)18.8(y)-245.6(t)12.3(o)]TJ
0 -1.1795 TD
[(bo)22.3(th)-439.6(ni)19.8(co)21(ti)18.8(ne)-439.8(an)15.8(d)-447.4(c)0(a)20.1(n)0(n)16.3(a)12.8(bi)20.2(s)-448.2(d)0(e)15.2(p)13(en)20.6(de)20.3(nc)15.5(e)12.5(.)]TJ
8.2191 0 0 7.3052 242.8724 366.0094 Tm
[(17)19.9(,)18(1)0(8)]TJ
10.959 0 0 10.959 264.9826 361.1338 Tm
-.013 Tc
[(Fu)-13(r)7.1(t)-13(h)7.8(e)-13(r)6.5(-)]TJ
-18.52 -1.1795 TD
0 Tc
[(m)10.2(o)0(r)20.8(e)0(,)-421.3(c)12.5(an)21(na)15.8(b)13.7(i)0(s)-421(u)13(se)19.5(rs)-420.4(t)12.3(i)0(t)18.8(r)0(a)19.8(t)0(e)-420.1(\()11.9(ad)15.5(j)12(u)13(st)19.4(\))-433(t)12.3(he)21(i)11.7(r)-432.7(d)13(o)0(s)20.8(e)-432.4(b)13.7(a)0(s)19.8(e)0(d)]TJ
0 -1.1847 TD
[(on)-412.7(th)20.8(e)-427.2(p)13(ot)20.8(en)15.5(c)12.5(y)-426.6(o)13.7(f)-428.1(c)12.5(a)0(n)21(n)0(a)21(b)0(i)20.2(s)-427.5(t)12.3(h)0(e)21(r)0(e)19.5(f)0(o)20.2(r)0(e)-415(m)10.2(od)21.6(if)18.2(yi)19.6(ng)-413.3(to)20.9(ta)19.9(l)]TJ
0 -1.1795 TD
[(TH)18.6(C)-202.7(e)0(x)14.9(p)13(os)20.8(ur)20.1(e.)]TJ
8.2191 0 0 7.3052 126.822 327.1747 Tm
[(19)26.8(,2)21(0)]TJ
10.959 0 0 10.959 146.211 322.2991 Tm
[(Ho)18.4(w)14.8(e)0(v)20.4(e)0(r)19.5(,)-211.4(t)12.3(h)0(u)21.5(s)-210.2(f)11.6(a)0(r)19.8(,)-211.4(w)14.8(h)0(e)21(t)0(h)20.8(e)0(r)-197.7(c)0(a)20.1(n)0(n)16.3(a)12.8(bi)20.2(s)]TJ
-7.6822 -1.1847 TD
[(us)20.1(er)19.5(s)-334.4(a)12.8(ls)19.1(o)-332.9(t)12.3(it)18.8(r)12.2(a)0(t)19.9(e)-334.1(t)12.3(h)0(e)15.8(i)11.7(r)-334.4(d)13(os)20.8(e)-334.1(t)12.3(o)-332.9(t)0(o)20.8(b)0(a)21.3(c)0(c)19.8(o)-332.9(co)21(nt)20.5(en)20.6(t)-334.3(h)0(a)21.3(s)-334.4(n)13.3(o)0(t)]TJ
0 -1.1795 TD
[(be)21(en)-279.4(in)19.8(ve)20.4(st)19.3(ig)19.6(at)19.9(ed)20.3(.)]TJ
.9984 -1.1847 TD
[(Two)-536.9(previous)-529.7(studies)-539(have)-532.5(investigated)-532.4(dose)-533.1(per)]TJ
-.9984 -1.1795 TD
[(joint)-304.2(using)-309.1(a)-307.9(cannabis)-306.3(substitute.)]TJ
8.2191 0 0 7.3052 206.9291 275.3574 Tm
(21,22)Tj
10.959 0 0 10.959 227.8488 270.4818 Tm
[(The)-306.5(rst)-306.5(did)-308.9(not)]TJ
-15.1315 -1.1847 TD
[(measure)-313(tobacco)]TJ
8.2191 0 0 7.3052 135.5527 262.3748 Tm
(21)Tj
10.959 0 0 10.959 143.433 257.4991 Tm
[(;)-309.7(the)-313.3(other)-308.1(used)-311.4(the)-308.1(same)-309.3(substitute)]TJ
-7.4287 -1.1795 TD
[(to)-222.3(measure)-219.8(both)-220.8(cannabis)-218.4(and)-224.7(tobacco)-219.2(\(which)-216.6(have)-222.1(dif-)]TJ
T*
[(ferent)-220.4(weights\))]TJ
8.2191 0 0 7.3052 126.7086 236.4661 Tm
(22)Tj
10.959 0 0 10.959 136.97 231.6472 Tm
[(and)-219.5(neither)-222.2(was)-218.8(conducted)-220.4(with)-216.5(cous-)]TJ
-6.8389 -1.1847 TD
[(ers)-371.8(who)-371.6(smoke)-367.7(joints,)-368.9(where)-368.8(this)-374.3(issue)-367.7(is)-374.4(particularly)]TJ
0 -1.1795 TD
(pertinent.)Tj
8.2191 0 0 7.3052 104.5417 210.6141 Tm
(11)Tj
10.959 0 0 10.959 115.5401 205.7385 Tm
[(In)-284.8(one)-286.4(Dutch)-280(study,)-287.4(van)-281.5(der)-288.2(Pol)-281.4(et)-285.6(al.)]TJ
8.2191 0 0 7.3052 281.6503 210.6141 Tm
(1)Tj
10.959 0 0 10.959 288.6802 205.7385 Tm
(es-)Tj
-20.6823 -1.1847 TD
[(timated)-287.7(dose)-290(per)-288.2(joint)-288.7(using)-288.4(actual)-286.7(cannabis,)-290.1(however,)]TJ
0 -1.1795 TD
[(the)-375.4(amount)-369.6(of)-373(tobacco)-369.2(was)-374(not)-374.5(estimated.)-370.9(Moreover,)]TJ
22.9068 47.2724 TD
[(there)-376.5(has)-375.2(been)-372.2(no)-376.5(research)-375.3(to)-372.3(date)-373.6(investigating)-374.9(how)]TJ
0 -1.1847 TD
[(acute)-604.2(intoxication)-603.5(may)-605.4(inuence)-601(self-reported)-603.2(and)]TJ
0 -1.1795 TD
[(actual)-297(dose)-290(per)-293.4(joint.)-293.2(To)-293.1(maximize)-288.6(the)-292.6(ecological)-292.5(rele-)]TJ
0 -1.1847 TD
[(vance)-235.8(of)-233.3(this)-234.6(laboratory)-228.3(study,)-235.7(our)-230()42.1(Roll)-232.1(a)-230.3(Joint)42.7()-232.1(proce-)]TJ
0 -1.1795 TD
[(dure)-482.1(used)-482.1(a)-478.7(typical)-481.6(brand)-478.1(of)-481.6(rolling)-475.8(tobacco)-477.8(and)-478.2(a)]TJ
0 -1.1847 TD
[(cannabis)-456.3(placebo,)-457.4(produced)-455.7(from)-454.1(active)-458(cannabis)-456.3(to)]TJ
0 -1.1795 TD
[(contain)-220.7(less)-220(than)-222.1(0.1%)-215.7(THC)-220.4(\(but)-218.1(with)-216.5(the)-220.2(same)-221.4(terpene)]TJ
T*
[(content,)-302.5(so)-294.8(it)-301.9(retains)-295.8(the)-297.8(look)-299.3(and)-297.1(smells)-296.2(of)-300.5(cannabis\).)]TJ
0 -1.1847 TD
[(We)-519.7(rst)-518.6(aimed)-519.3(to)-517.2(compare)-518.4(peoples)-520.7(estimated)-516.5(and)]TJ
0 -1.1795 TD
[(actual)-312.6(dose)-310.7(of)-310.9(cannabis)-311.5(and)-312.6(tobacco)-307.1(in)-311.2(joints.)-312(Second,)]TJ
0 -1.1847 TD
[(we)-557.3(aimed)-550.3(to)-553.4(investigate)-550.5(how)-552.7(estimated)-552.7(and)-550.6(actual)]TJ
0 -1.1795 TD
[(dose)-341.7(per)-339.9(joint)-335.3(is)-338.2(inuenced)-339.7(by)-335.3(smoking)-336.9(cannabis)-337.4(and)]TJ
0 -1.1847 TD
[(tobacco,)-301.2(both)-298.4(individually)-299.6(and)-297.1(combined)-302.9(in)-295.7(joints.)]TJ
/F4 1 Tf
10.4607 0 0 10.4607 313.0582 516.529 Tm
/Cs8 cs 1 scn
[(Materials)-302.5(and)-303.8(Methods)]TJ
/F8 1 Tf
0 -1.2357 TD
[(Design)-302.7(and)-298.4(participants)]TJ
/F7 1 Tf
10.959 0 0 10.959 313.0582 490.677 Tm
0 0 0 rg
[(Participants)-392.7(took)-386.9(part)-394.6(in)-388.8(a)-390.7(baseline)-390.7(session)-388.1(and)-390.2(then)]TJ
0 -1.1847 TD
[(four)-296(acute)-299(drug)-295.2(sessions.)-297.5(The)-291(acute)-299(effects)-292.4(of)-295.4(cannabis)]TJ
0 -1.1795 TD
[(and)-250.5(tobacco,)-249.5(both)-246.6(alone)-251.2(and)-250.5(combined,)-250.5(were)-248(evaluated)]TJ
0 -1.1847 TD
-.0001 Tc
[(using)-360.9(a)-359.8(randomized,)-360.8(double-blind,)-357.2(placebo-controlled)]TJ
0 -1.1795 TD
0 Tc
[(four-way)-522.1(crossover)-521.9(design.)-523.5(Previous)-523.9(data)-518.1(from)-521.3(this)]TJ
0 -1.1847 TD
[(study)-334.7(have)-325.6(been)-330.8(published)-330(elsewhere)-330(on)-329.9(memory)-326.5(and)]TJ
0 -1.1795 TD
[(psychotomimetic)-580.5(effects)]TJ
8.2191 0 0 7.3052 422.0219 417.8267 Tm
(15)Tj
10.959 0 0 10.959 436.2519 412.9511 Tm
[(and)-581.6(reward)-579.4(processing.)]TJ
8.2191 0 0 7.3052 544.3085 417.8267 Tm
(23)Tj
10.959 0 0 10.959 313.0582 399.9684 Tm
[(The)-342.7(four)-342.6(drug)-341.8(administration)-344.1(sessions)-339.6(\(Table)-342.2(1\))-342(were)]TJ
T*
[(separated)-310.9(by)-309.4(at)-311.2(least)-310.6(1-week)-309.1(washout)-305.8(\()]TJ
/F5 1 Tf
15.6333 0 TD
()Tj
/F7 1 Tf
.5846 0 TD
[(3)-307.3(times)-308.5(elimi-)]TJ
-16.2179 -1.1847 TD
[(nation)-321.2(half-life)-318.8(of)-316.1(THC\).)]TJ
8.2191 0 0 7.3052 422.6455 378.9353 Tm
(24,25)Tj
10.959 0 0 10.959 443.6786 374.0597 Tm
[(Order)-318.1(of)-316.1(drug)-321.1(treatment)]TJ
-11.919 -1.1795 TD
[(was)-301.6(determined)-301(by)-299.1(a)-297.6(balanced)-300.8(Latin)-298.3(square.)]TJ
1.0036 -1.1795 TD
[(Medically)-551.8(and)-555.8(psychiatrically)-552.1(healthy,)-550.7(nondepen-)]TJ
-1.0036 -1.1847 TD
[(dent)-461(but)-452.4(experienced,)-460.9(cannabis)-451.2(and)-457.5(tobacco)-457.1(cousers)]TJ
0 -1.1795 TD
[(\(i.e.,)-256.6()42.1(joint)49()-257.9(smokers\))-253.8(were)-253.2(recruited)-255.4(from)-252.3(the)-251.2(commu-)]TJ
0 -1.1847 TD
[(nity.)-269.6(Inclusion)-268.7(criteria)-269.4(were)-268.7(as)-264.7(follows:)-266(\(i\))-269.7(1860)-269.2(years;)]TJ
0 -1.1795 TD
[(\(ii\))-382.2(regular)-377.7(use)-381.3(\()]TJ
/F5 1 Tf
6.8286 0 TD
(>)Tj
/F7 1 Tf
.5794 0 TD
[(once/month)-375(but)]TJ
/F5 1 Tf
6.989 0 TD
(<)Tj
/F7 1 Tf
.5794 0 TD
[(3)-379.7(times/week\))-376.9(of)]TJ
-14.9763 -1.1847 TD
[(cannabis)-275.3(mixed)-271(with)-273.4(tobacco)-270.9(in)-275(joints)-271.3(for)-272.8(the)-271.9(previous)]TJ
0 -1.1795 TD
[(6)-234.9(months;)-229.1(\(iii\))-230.8(self-reported)-235.9(ability)-228.2(to)-232.6(smoke)-228.1(one)-234.6(whole)]TJ
0 -1.1847 TD
[()42.1(standard)46.2()-413.1(joint;)-412.2(\(iv\))-417(normal)-412(or)-408.6(corrected)-414.2(to)-413.7(normal)]TJ
0 -1.1795 TD
[(vision;)-321.9(\(v\))-314.8(uent)-318(English;)-318.3(\(vi\))-318.7(self-reported)-313.5(abstinence)]TJ
T*
[(from)-397.2(tobacco,)-389.2(cannabis,)-398.7(alcohol,)-389.9(and)-395.4(other)-390.8(drugs)-396.8(for)]TJ
0 -1.1847 TD
[(at)-254.3(least)-248.6(12)-164.6(h)-250.1(before)-254.8(each)-248.6(test)-250.7(day;)-250.1(and)-250.5(\(vii\))-255.3(alveolar)-245.4(car-)]TJ
0 -1.1795 TD
[(bon)-517.9(monoxide)-514.8(\(CO\))]TJ
/F5 1 Tf
9.2186 0 TD
()Tj
/F7 1 Tf
.5794 0 TD
[(6)-167.6(ppm)-517.3(to)-512(conrm)-514.2(no)-516.1(recent)]TJ
-9.798 -1.1847 TD
[(smoking)-305.9(on)-304(each)-305.5(test)-307.6(day.)]TJ
8.2191 0 0 7.3052 428.2015 197.6315 Tm
(12)Tj
10.959 0 0 10.959 439.4266 192.7559 Tm
[(Exclusion)-304.1(criteria)-305.6(were)-304.9(as)]TJ
-11.531 -1.1795 TD
[(follows:)-229.8(\(i\))]TJ
/F5 1 Tf
4.4903 0 TD
()Tj
/F7 1 Tf
.5794 0 TD
[(3)-229.7(o)0(n)-231.6(the)-230.5(Cannabis)-226.7(Severity)-230.9(of)-233.3(Dependence)]TJ
ET
/EmbeddedDocument /MC5 BDC
/Document /MC6 BDC
q
1 i
572.031 35.263 10.035 -19.162 re
W n
.88034 .35499 .53448 .13513 k
q 1 0 0 1 572.031 16.059 cm 0 0 m
.966 3.153 1.461 4.22 v
1.739 4.818 2.425 6.378 3.087 7.332 c
3.497 7.924 4.368 8.916 4.541 9.196 c
4.633 9.338 4.701 9.556 y
4.901 9.641 5.09 9.748 v
5.279 9.856 5.638 10.053 5.702 10.24 c
5.807 10.549 5.997 10.624 y
6.187 10.665 6.271 10.678 v
6.44 10.7 6.566 10.773 6.735 10.859 c
6.904 10.946 7.12 11.062 7.516 11.253 c
7.799 11.391 10.08 12.245 y
10.048 12.162 9.858 12.011 v
9.667 11.863 9.25 11.707 9.083 11.621 c
8.914 11.536 7.475 10.817 7.199 10.646 c
6.926 10.474 6.091 9.925 5.47 9.366 c
5.02 8.96 4.51 8.356 4.184 7.914 c
3.263 6.665 2.748 5.394 y
3.551 5.415 3.613 5.415 v
3.676 5.415 3.845 4.924 y
3.212 5.01 2.938 4.861 v
2.663 4.712 2.592 4.659 2.358 4.273 c
2.129 3.895 1.618 2.108 1.314 1.137 c
1.22 .833 1.125 .399 .936 .306 c
.813 .243 0 0 y
f
Q
Q
.8706 .35352 .53033 .13062 K
0 J 0 j .405 w 4 M []0 d
/GS2 gs
1 i
q 1 0 0 1 577.63 22.436 cm 0 0 m
.403 .006 .637 -.007 v
.776 -.013 .996 -.05 1.152 -.097 c
1.288 -.142 1.451 -.222 1.542 -.287 c
1.659 -.373 1.711 -.47 1.783 -.567 c
1.832 -.637 1.991 -1.045 2.063 -1.095 c
2.136 -1.142 2.146 -1.179 2.081 -1.222 c
2.03 -1.257 2.004 -1.324 1.984 -1.373 c
1.965 -1.424 1.89 -1.613 1.84 -1.767 c
1.802 -1.888 1.742 -1.958 1.704 -2.004 c
1.646 -2.071 1.529 -2.169 1.405 -2.236 c
1.312 -2.284 1.146 -2.357 .995 -2.388 c
.716 -2.45 .292 -2.479 .174 -2.469 c
S
Q
.88034 .35499 .53448 .13513 k
q 1 0 0 1 576.761 19.774 cm 0 0 m
-.054 0 -.095 .021 -.095 .045 c
-.095 .068 -.054 .088 0 .088 c
.05 .088 .094 .068 .094 .045 c
.094 .021 .05 0 0 0 c
-.35 .372 m
-.35 .416 -.271 .451 -.175 .451 c
-.08 .451 0 .416 0 .372 c
0 .328 -.08 .292 -.175 .292 c
-.271 .292 -.35 .328 -.35 .372 c
-.46 .766 m
-.46 .826 -.36 .874 -.238 .874 c
-.116 .874 -.018 .826 -.018 .766 c
-.018 .705 -.116 .656 -.238 .656 c
-.36 .656 -.46 .705 -.46 .766 c
-.586 1.181 m
-.586 1.262 -.477 1.325 -.34 1.325 c
-.206 1.325 -.095 1.262 -.095 1.181 c
-.095 1.101 -.206 1.036 -.34 1.036 c
-.477 1.036 -.586 1.101 -.586 1.181 c
-.19 1.641 m
-.19 1.587 -.269 1.545 -.364 1.545 c
-.462 1.545 -.539 1.587 -.539 1.641 c
-.539 1.691 -.462 1.732 -.364 1.732 c
-.269 1.732 -.19 1.691 -.19 1.641 c
-.373 2.112 m
-.265 2.112 -.175 2.066 -.175 2.012 c
-.175 1.954 -.265 1.908 -.373 1.908 c
-.481 1.908 -.569 1.954 -.569 2.012 c
-.569 2.066 -.481 2.112 -.373 2.112 c
-.303 2.491 m
-.215 2.491 -.143 2.459 -.143 2.418 c
-.143 2.379 -.215 2.347 -.303 2.347 c
-.39 2.347 -.46 2.379 -.46 2.418 c
-.46 2.459 -.39 2.491 -.303 2.491 c
-.175 2.753 m
-.131 2.753 -.095 2.735 -.095 2.708 c
-.095 2.688 -.131 2.666 -.175 2.666 c
-.22 2.666 -.255 2.688 -.255 2.708 c
-.255 2.735 -.22 2.753 -.175 2.753 c
1.513 .335 m
1.371 .352 1.288 .352 1.196 .352 c
1.101 .352 1.021 .346 .69 .352 c
.478 .355 .535 .471 .729 .496 c
.809 .507 .849 .51 .896 .518 c
.944 .525 .991 .532 1.212 .576 c
1.433 .62 1.308 .699 1.138 .712 c
1.009 .72 .952 .722 .903 .722 c
.824 .722 .78 .724 .569 .738 c
.3 .763 .425 .882 .548 .904 c
.611 .914 .637 .918 .675 .926 c
.715 .935 .738 .941 .984 .977 c
1.229 1.013 1.118 1.099 .976 1.109 c
.833 1.126 .809 1.13 .741 1.134 c
.68 1.137 .642 1.136 .471 1.158 c
.312 1.181 .375 1.266 .461 1.286 c
.547 1.308 .606 1.32 .661 1.321 c
.694 1.324 .723 1.33 .889 1.355 c
1.113 1.388 1.118 1.479 .868 1.512 c
.743 1.529 .723 1.53 .698 1.533 c
.661 1.54 .64 1.545 .44 1.566 c
.251 1.588 .304 1.698 .471 1.72 c
.589 1.734 .658 1.743 .69 1.749 c
.723 1.752 .77 1.752 .929 1.77 c
1.143 1.795 1.156 1.899 .936 1.918 c
.809 1.933 .797 1.93 .745 1.934 c
.715 1.937 .705 1.933 .485 1.953 c
.286 1.97 .358 2.07 .494 2.092 c
.62 2.112 .71 2.128 .802 2.142 c
.833 2.146 .858 2.14 1.131 2.2 c
1.284 2.233 1.25 2.308 1.068 2.315 c
1.002 2.32 .884 2.331 .793 2.339 c
.715 2.347 .666 2.347 .517 2.359 c
.366 2.374 .494 2.484 .548 2.499 c
.604 2.514 .84 2.536 .965 2.543 c
1.094 2.55 1.284 2.556 1.394 2.587 c
1.492 2.614 1.433 2.673 1.338 2.695 c
1.29 2.705 1.261 2.713 1.182 2.728 c
1.101 2.742 1.046 2.745 .965 2.761 c
.872 2.78 .889 2.769 .849 2.789 c
.809 2.815 .759 2.899 y
.729 2.985 .683 2.985 v
.636 2.985 .563 2.987 .421 2.987 c
.28 2.987 .326 2.995 .265 2.995 c
.2 2.995 .112 3.01 .026 3.016 c
-.061 3.024 -.171 3.03 -.227 3.024 c
-.281 3.016 -.358 2.992 -.417 2.959 c
-.504 2.906 -.622 2.778 -.692 2.695 c
-.764 2.614 -.875 2.397 -.915 2.323 c
-.954 2.251 -1.08 1.887 -1.129 1.808 c
-1.175 1.727 -1.302 1.675 y
-1.511 1.573 -1.387 1.54 v
-.964 1.423 -1.325 1.269 y
-1.31 1.172 l
-1.27 1.172 -1.262 1.153 v
-1.254 1.13 -1.129 1.158 -1.024 .874 c
-.977 .742 -.933 .651 -.85 .468 c
-.811 .38 -.677 .054 -.446 -.092 c
-.195 -.252 .012 -.207 .121 -.194 c
.251 -.181 .471 -.128 .581 -.125 c
.723 -.114 .763 -.114 .88 -.107 c
.999 -.099 1.361 -.092 y
.873 0 .778 0 v
.683 0 1.007 .094 1.142 .116 c
1.261 .139 1.378 .168 y
1.418 .184 1.553 .212 v
1.688 .242 1.655 .321 1.513 .335 c
f
Q
q
572.031 35.263 10.035 -19.162 re
W n
.88034 .35499 .53448 .13513 K
q 1 0 0 1 576.744 25.907 cm 0 0 m
-.066 -.119 -.079 -.096 v
-.122 .003 -.244 .254 -.395 .343 c
-.586 .454 -1.661 .89 -1.821 .965 c
-1.948 1.026 -2.464 1.133 -2.75 1.614 c
-3.04 2.104 -3.099 2.207 -3.229 2.355 c
-3.403 2.553 -3.277 2.712 -3.07 2.738 c
-2.962 2.752 -2.821 2.753 -2.718 2.753 c
-2.656 2.754 -2.654 2.877 -2.658 3.009 c
-2.668 3.222 -2.723 3.28 -2.881 3.41 c
-3.04 3.536 -3.323 3.744 -3.387 3.921 c
-3.451 4.096 -3.373 4.398 -3.53 4.526 c
-3.687 4.656 -4.023 4.897 -4.1 5.244 c
-4.164 5.532 -4.025 5.669 -3.927 5.723 c
-3.772 5.808 -3.609 5.804 -3.482 5.676 c
-3.354 5.549 -3.341 5.389 -3.277 5.311 c
-3.214 5.229 -3.051 5.181 -2.976 5.149 c
-2.875 5.106 -2.769 5.065 -2.643 5.032 c
-2.598 5.021 -2.38 4.925 -2.339 5.021 c
-2.302 5.102 -2.351 5.196 -2.389 5.311 c
-2.47 5.532 -3.008 5.771 -3.07 5.837 c
-3.134 5.899 -3.335 6.063 -3.403 6.377 c
-3.467 6.671 -3.468 6.71 -3.53 6.857 c
-3.637 7.108 -3.585 7.299 -3.552 7.427 c
-3.51 7.591 -3.627 7.705 -3.547 7.8 c
-3.446 7.916 -3.299 7.981 -3.198 7.911 c
-3.122 7.856 -3.023 7.773 -2.96 7.726 c
-2.895 7.676 -2.854 7.64 -2.707 7.554 c
-2.596 7.489 -2.439 7.54 -2.327 7.512 c
-2.242 7.489 -2.082 7.349 -2.074 7.364 c
-2.025 7.443 -2.058 7.561 -2.074 7.688 c
-2.09 7.814 -2.216 8.07 -2.247 8.151 c
-2.28 8.23 -2.31 8.359 -2.231 8.469 c
-2.153 8.582 -1.963 8.82 -1.868 8.932 c
-1.773 9.045 -1.661 9.284 -1.504 9.061 c
-1.344 8.836 -1.282 8.694 -1.202 8.646 c
-1.124 8.597 -1.039 8.597 -.917 8.63 c
-.799 8.661 -.646 8.694 -.537 8.726 c
-.426 8.755 -.346 8.836 -.252 8.902 c
-.157 8.965 -.093 8.98 -.03 8.948 c
.033 8.917 .059 8.874 .097 8.789 c
.122 8.729 .122 8.63 .144 8.55 c
.184 8.396 .229 8.322 .207 8.263 c
.159 8.129 .065 8.024 .033 7.927 c
0 7.831 .059 7.567 .018 7.496 c
-.046 7.383 -.109 7.352 -.141 7.239 c
-.173 7.13 -.141 7.001 -.093 6.905 c
-.046 6.811 -.046 6.714 -.03 6.634 c
-.014 6.554 .082 6.603 .144 6.681 c
.207 6.762 .207 6.841 .271 6.953 c
.334 7.064 .491 7.064 .635 7.082 c
.764 7.095 .925 7.258 1.063 7.273 c
1.141 7.281 1.285 7.242 1.348 7.13 c
1.442 6.957 1.458 6.793 1.378 6.664 c
1.3 6.539 1.18 6.429 1.143 6.282 c
1.094 6.097 1.074 5.872 .968 5.723 c
.866 5.581 .727 5.501 .635 5.358 c
.533 5.191 .508 4.877 .555 4.718 c
.604 4.558 .661 4.602 .698 4.687 c
.746 4.795 .787 4.904 .888 4.957 c
1.086 5.061 1.327 5.17 1.475 5.181 c
1.554 5.186 1.712 5.102 1.775 4.973 c
1.839 4.846 1.816 4.657 1.79 4.526 c
1.737 4.276 1.671 4.01 1.602 3.921 c
1.505 3.796 1.391 3.694 1.237 3.584 c
1.08 3.473 .715 3.298 .57 3.201 c
.407 3.091 .323 2.923 .292 2.797 c
.261 2.673 .302 2.578 .382 2.578 c
.46 2.578 .555 2.721 .604 2.785 c
.65 2.851 .705 2.992 .798 3.009 c
.904 3.03 1.031 2.963 1.143 2.963 c
1.253 2.963 1.316 3.009 1.442 3.042 c
1.569 3.073 1.649 2.999 1.632 2.871 c
1.616 2.744 1.616 2.674 1.553 2.593 c
1.49 2.513 1.316 2.419 1.3 2.307 c
1.284 2.194 1.318 2.064 1.3 1.972 c
1.273 1.838 1.143 1.747 1.016 1.635 c
.888 1.525 .46 1.179 .367 .981 c
.3 .844 .3 .566 .318 .454 c
.345 .294 .398 .262 y
.431 .262 .132 .139 .121 .127 c
.047 .055 0 0 y
h
S 1 0 0 1 1.403 6.747 cm 0 0 m
.079 .046 .119 .094 .222 .199 c
.324 .301 .436 .422 .505 .501 c
.559 .56 .696 .684 .768 .806 c
.828 .905 .87 .941 .95 .949 c
.997 .953 1.107 .949 1.164 .972 c
1.22 .996 1.367 1.077 1.417 1.115 c
1.456 1.149 1.679 1.195 1.728 1.021 c
1.777 .829 1.784 .588 1.757 .526 c
1.693 .374 1.6 .262 1.552 .11 c
1.522 .022 1.527 -.153 1.583 -.312 c
1.633 -.459 1.703 -.393 1.798 -.337 c
1.893 -.281 1.964 -.25 2.041 -.258 c
2.121 -.266 2.462 -.312 2.51 -.322 c
2.556 -.328 2.636 -.37 2.612 -.449 c
2.589 -.527 2.431 -.817 2.312 -.92 c
2.192 -1.024 2.105 -1.111 2.083 -1.175 c
2.058 -1.238 1.995 -1.406 1.985 -1.487 c
1.979 -1.566 1.853 -1.718 1.78 -1.765 c
1.709 -1.812 1.393 -2.014 1.346 -2.054 c
1.299 -2.091 1.11 -2.161 1.274 -2.349 c
1.393 -2.484 1.4 -2.421 1.456 -2.413 c
1.513 -2.403 1.545 -2.391 1.646 -2.324 c
1.757 -2.254 1.86 -2.229 1.972 -2.277 c
2.083 -2.324 2.163 -2.357 2.192 -2.403 c
2.257 -2.499 2.202 -2.581 2.176 -2.62 c
2.146 -2.671 1.868 -2.946 1.813 -3.003 c
1.757 -3.059 1.527 -3.259 1.456 -3.315 c
1.387 -3.371 1.22 -3.529 1.171 -3.633 c
1.124 -3.738 1.068 -3.953 1.021 -4.034 c
.974 -4.113 .775 -4.295 .607 -4.407 c
.442 -4.52 .135 -4.736 .071 -4.847 c
.027 -4.922 -.008 -5.127 -.025 -5.288 c
-.04 -5.446 0 -5.589 y
-.119 -5.614 -.205 -5.638 v
-.294 -5.662 -.364 -5.741 -.364 -5.798 c
-.364 -5.853 -.491 -5.988 y
-.477 -5.853 -.554 -5.766 v
-.634 -5.676 -.713 -5.567 -.761 -5.542 c
S
Q
Q
q 1 0 0 1 576.579 25.908 cm 0 0 m
.054 .175 l
-.08 .388 -.135 .459 v
-.19 .531 -.809 1.001 -.901 1.074 c
-.995 1.145 -1.305 1.351 -1.409 1.39 c
-2.032 1.677 -2.075 1.693 v
-2.12 1.712 -2.419 1.883 -2.468 1.909 c
-2.517 1.936 -2.639 2.005 -2.678 2.031 c
-2.715 2.059 -2.748 2.122 -2.748 2.148 c
-2.748 2.176 -2.731 2.227 -2.71 2.221 c
-2.687 2.216 -2.639 2.221 -2.616 2.197 c
-2.596 2.176 -2.507 2.138 -2.456 2.109 c
-2.406 2.081 -2.037 1.901 -1.993 1.879 c
-1.949 1.854 -1.623 1.689 -1.574 1.671 c
-1.523 1.654 -1.294 1.545 -1.255 1.522 c
-1.217 1.501 -1.133 1.445 -1.077 1.418 c
-1.021 1.39 -.901 1.316 -.873 1.297 c
-.848 1.272 -.72 1.179 -.692 1.145 c
-.664 1.114 -.477 .996 -.454 .978 c
-.433 .964 -.301 .836 -.278 .825 c
-.257 .813 -.18 .759 -.162 .754 c
-.146 .747 -.112 .729 -.092 .74 c
-.067 .754 -.057 .818 -.063 .852 c
-.067 .886 -.162 1.346 -.18 1.424 c
-.194 1.501 -.262 1.833 -.278 1.888 c
-.296 1.942 -.41 2.109 -.516 2.187 c
-.619 2.266 -1.105 2.664 -1.166 2.702 c
-1.227 2.739 -1.508 2.946 -1.585 2.984 c
-1.663 3.024 -1.91 3.179 -1.977 3.223 c
-2.044 3.268 -2.374 3.495 -2.43 3.545 c
-2.484 3.594 -2.864 4.004 -2.936 4.082 c
-3.009 4.16 -3.274 4.55 -3.332 4.646 c
-3.393 4.747 -3.538 4.891 -3.603 4.974 c
-3.671 5.057 -3.734 5.167 -3.741 5.207 c
-3.746 5.247 -3.696 5.334 -3.603 5.258 c
-3.511 5.179 -3.454 5.124 -3.399 5.086 c
-3.344 5.046 -3.3 5.003 -3.262 4.945 c
-3.224 4.891 -3.151 4.796 -3.123 4.753 c
-3.096 4.708 -2.97 4.515 -2.926 4.454 c
-2.883 4.392 -2.706 4.136 -2.605 4.022 c
-2.507 3.903 -2.253 3.635 -1.784 3.351 c
-1.317 3.068 -.757 2.691 -.697 2.658 c
-.637 2.623 -.592 2.576 -.554 2.576 c
-.516 2.576 -.498 2.598 -.487 2.623 c
-.477 2.652 -.521 2.758 -.544 2.829 c
-.565 2.901 -.603 3.279 -.626 3.383 c
-.648 3.488 -.823 4.42 -.848 4.499 c
-.867 4.575 -.852 4.715 -1.001 4.806 c
-1.148 4.902 -1.547 5.194 -1.618 5.252 c
-1.69 5.306 -2.264 5.859 -2.324 5.927 c
-2.386 5.992 -2.673 6.332 -2.721 6.38 c
-2.771 6.432 -2.941 6.636 -2.981 6.741 c
-3.018 6.846 -3.047 6.912 -3.079 6.99 c
-3.113 7.068 -3.185 7.234 -3.206 7.283 c
-3.228 7.335 -3.25 7.416 -3.245 7.434 c
-3.239 7.45 -3.218 7.473 -3.175 7.45 c
-3.129 7.428 -3.024 7.29 -3.004 7.251 c
-2.981 7.213 -2.876 7.046 -2.858 7.002 c
-2.843 6.958 -2.803 6.868 -2.776 6.823 c
-2.748 6.781 -2.534 6.476 -2.462 6.402 c
-2.391 6.332 -2.147 6.07 -2.087 6.016 c
-2.027 5.961 -1.518 5.449 -1.435 5.379 c
-1.353 5.306 -1.188 5.2 -1.144 5.184 c
-1.101 5.167 -1.057 5.167 -1.035 5.179 c
-1.011 5.189 -.984 5.222 -.99 5.322 c
-.995 5.423 -1.105 6.353 -1.128 6.486 c
-1.148 6.621 -1.271 7.022 -1.3 7.135 c
-1.325 7.245 -1.364 7.571 -1.392 7.794 c
-1.419 8.016 -1.568 8.645 -1.613 8.737 c
-1.657 8.824 -1.686 8.912 -1.705 8.963 c
-1.728 9.012 -1.767 9.105 -1.739 9.152 c
-1.714 9.195 -1.646 9.339 -1.613 9.334 c
-1.579 9.329 -1.534 9.31 -1.514 9.272 c
-1.491 9.233 -1.446 8.984 -1.435 8.935 c
-1.426 8.884 -1.31 8.337 -1.305 8.293 c
-1.3 8.247 -1.242 8.098 -1.232 8.038 c
-1.223 7.976 -1.184 7.728 -1.178 7.622 c
-1.172 7.517 -1.139 7.406 -1.111 7.385 c
-1.083 7.361 -1.05 7.367 -1.018 7.379 c
-.984 7.389 -.945 7.522 -.911 7.583 c
-.88 7.643 -.71 7.905 -.671 7.947 c
-.631 7.991 -.537 8.198 -.516 8.237 c
-.493 8.275 -.388 8.48 -.356 8.535 c
-.321 8.592 -.229 8.714 -.2 8.755 c
-.174 8.79 -.129 8.867 -.102 8.863 c
-.074 8.857 -.009 8.824 y
.048 8.784 .014 8.709 v
-.018 8.63 -.14 8.486 -.174 8.432 c
-.207 8.377 -.345 8.128 -.388 8.026 c
-.433 7.928 -.615 7.711 -.644 7.667 c
-.671 7.622 -.775 7.373 -.813 7.283 c
-.852 7.193 -.919 7.018 -.935 6.924 c
-.95 6.83 -.919 6.396 -.906 6.332 c
-.896 6.265 -.79 5.526 -.78 5.395 c
-.769 5.262 -.736 5.057 -.72 4.997 c
-.702 4.935 -.687 4.764 -.676 4.663 c
-.664 4.564 -.659 4.509 -.631 4.481 c
-.603 4.454 -.565 4.447 -.544 4.465 c
-.521 4.481 -.382 4.698 -.349 4.747 c
-.316 4.796 -.169 5.04 -.146 5.067 c
-.123 5.097 .108 5.35 .18 5.407 c
.253 5.461 .394 5.59 .449 5.683 c
.505 5.776 .561 5.882 .621 6.032 c
.681 6.182 .731 6.409 .77 6.47 c
.81 6.529 .896 6.697 .931 6.741 c
.963 6.787 1.14 7.002 1.194 7.033 c
1.25 7.068 1.305 7.117 1.338 7.117 c
1.37 7.117 1.403 7.074 1.397 7.04 c
1.394 7.008 1.338 6.944 1.315 6.92 c
1.296 6.891 1.129 6.691 1.101 6.636 c
1.072 6.581 .913 6.265 .896 6.192 c
.88 6.121 .831 5.91 .798 5.844 c
.764 5.776 .72 5.667 .647 5.566 c
.576 5.467 .466 5.362 .372 5.272 c
.279 5.184 .081 5.029 .004 4.895 c
-.074 4.764 -.339 4.38 -.373 4.277 c
-.406 4.172 -.576 3.938 -.472 3.523 c
-.367 3.107 -.333 3.019 y
-.321 2.901 -.262 2.936 v
-.2 2.968 -.146 3.102 -.097 3.156 c
-.047 3.212 .141 3.434 .19 3.477 c
.24 3.523 .389 3.665 .477 3.738 c
.566 3.811 .852 4.031 .907 4.071 c
.963 4.11 1.167 4.287 1.212 4.337 c
1.255 4.388 1.382 4.582 1.409 4.612 c
1.438 4.646 1.496 4.708 1.531 4.708 c
1.564 4.708 1.619 4.675 1.603 4.612 c
1.586 4.555 1.543 4.475 1.491 4.397 c
1.442 4.321 1.37 4.216 1.338 4.176 c
1.305 4.136 1.194 4.056 1.145 4.009 c
1.095 3.967 .88 3.827 .81 3.761 c
.736 3.695 .652 3.635 .512 3.502 c
.365 3.366 .312 3.323 .229 3.223 c
.147 3.125 0 2.885 -.041 2.792 c
-.08 2.696 -.135 2.498 -.135 2.427 c
-.135 2.353 -.097 2.031 -.063 1.883 c
-.03 1.732 -.03 1.599 .014 1.549 c
.059 1.501 .091 1.506 .118 1.527 c
.147 1.549 .168 1.645 .208 1.693 c
.246 1.743 .284 1.788 .322 1.833 c
.362 1.879 .5 1.993 .543 2.026 c
.587 2.059 .692 2.148 .746 2.187 c
.804 2.227 .958 2.387 1.013 2.42 c
1.067 2.455 1.15 2.514 1.188 2.52 c
1.229 2.524 1.319 2.547 1.343 2.542 c
1.366 2.538 1.426 2.504 1.388 2.458 c
1.349 2.414 1.217 2.298 1.188 2.275 c
1.161 2.254 1.007 2.122 .936 2.059 c
.862 1.999 .72 1.904 .665 1.86 c
.61 1.816 .517 1.727 .472 1.671 c
.429 1.615 .362 1.506 .328 1.424 c
.295 1.339 .246 1.114 .229 .99 c
.212 .867 .24 .724 .253 .687 c
.263 .646 .267 .609 .279 .575 c
.29 .543 .345 .452 .365 .569 c
.389 .687 .417 .874 .477 .946 c
.537 1.02 .715 1.25 .731 1.095 c
.746 .94 .556 .598 .569 .475 c
.587 .354 .551 .192 .482 .092 c
.417 -.007 .196 -.072 .158 -.067 c
.118 -.062 0 0 y
f
Q
q 1 0 0 1 578.21 27.082 cm 0 0 m
.164 .542 .176 .587 v
.188 .631 .131 .741 .121 .775 c
.109 .81 .054 .932 .054 .984 c
.054 1.042 .065 1.107 .109 1.13 c
.153 1.153 .176 1.175 .231 1.239 c
.285 1.308 .341 1.363 .351 1.462 c
.363 1.561 .351 1.596 .386 1.673 c
.418 1.75 .462 1.817 .551 1.872 c
.638 1.928 .693 1.993 .772 2.037 c
.849 2.081 .926 2.172 .98 2.228 c
1.036 2.282 1.148 2.393 1.213 2.427 c
1.279 2.461 1.345 2.482 1.411 2.491 c
1.476 2.505 1.521 2.516 1.599 2.537 c
1.676 2.56 1.753 2.659 1.775 2.692 c
1.797 2.726 1.786 2.825 1.664 2.78 c
1.543 2.735 1.366 2.692 1.313 2.682 c
1.256 2.669 1.114 2.637 1.07 2.592 c
1.025 2.549 .97 2.461 .849 2.383 c
.728 2.304 .65 2.206 .584 2.206 c
.517 2.206 .484 2.206 .508 2.315 c
.529 2.427 .54 2.592 .574 2.726 c
.606 2.857 .65 3.058 .672 3.157 c
.693 3.259 .737 3.445 .804 3.469 c
.87 3.489 .991 3.545 1.091 3.645 c
1.19 3.744 1.323 3.866 1.4 3.954 c
1.476 4.042 1.599 4.276 1.664 4.331 c
1.73 4.388 1.84 4.509 1.952 4.553 c
2.062 4.598 1.996 4.589 2.161 4.62 c
2.326 4.653 2.37 4.644 2.437 4.686 c
2.503 4.731 2.548 4.775 2.514 4.786 c
2.481 4.797 2.481 4.797 2.415 4.831 c
2.349 4.863 2.293 4.907 2.216 4.887 c
2.14 4.863 2.05 4.843 1.974 4.809 c
1.897 4.775 1.709 4.696 1.653 4.62 c
1.599 4.542 1.433 4.366 1.378 4.299 c
1.323 4.233 1.224 4.11 1.179 4.057 c
1.134 3.999 1.08 3.945 1.025 3.912 c
.97 3.878 .837 3.844 .87 3.978 c
.904 4.11 .915 4.255 .949 4.398 c
.98 4.542 1.014 4.809 1.091 4.887 c
1.168 4.965 1.289 5.098 1.345 5.151 c
1.4 5.206 1.476 5.328 1.378 5.317 c
1.279 5.307 1.224 5.417 1.235 5.496 c
1.245 5.574 1.279 5.827 1.313 5.938 c
1.345 6.05 1.423 6.248 1.456 6.315 c
1.488 6.381 1.5 6.436 1.588 6.525 c
1.676 6.615 1.808 6.647 1.719 6.727 c
1.631 6.803 1.313 6.959 1.411 6.925 c
1.51 6.892 1.4 6.77 1.389 6.727 c
1.378 6.682 1.323 6.626 1.289 6.525 c
1.256 6.427 1.19 6.283 1.168 6.183 c
1.148 6.082 1.058 5.807 1.047 5.672 c
1.036 5.539 .991 5.496 .991 5.45 c
.991 5.406 .915 5.328 .86 5.429 c
.804 5.528 .804 5.607 .782 5.695 c
.76 5.783 .772 5.871 .76 5.928 c
.75 5.982 .617 6.082 .617 5.938 c
.617 5.794 .606 5.761 .617 5.695 c
.627 5.628 .627 5.561 .638 5.474 c
.65 5.385 .716 5.131 .75 5.074 c
.782 5.019 .849 4.887 .826 4.775 c
.804 4.664 .75 4.589 .728 4.509 c
.704 4.434 .661 4.276 .508 4.441 c
.351 4.609 -.065 5.273 -.1 5.317 c
-.134 5.363 -.177 5.395 -.221 5.284 c
-.265 5.175 -.299 5.295 -.211 5.141 c
-.123 4.986 -.033 4.852 .021 4.731 c
.076 4.609 .176 4.498 .231 4.419 c
.285 4.344 .351 4.276 .407 4.188 c
.462 4.1 .484 4.089 .473 3.889 c
.462 3.689 .407 3.29 .351 2.914 c
.297 2.537 .231 2.206 .176 2.116 c
.121 2.027 .109 1.982 0 2.072 c
-.111 2.16 -.078 2.26 -.123 2.304 c
-.167 2.351 -.243 2.404 -.32 2.36 c
-.397 2.315 -.541 2.238 -.53 2.172 c
-.519 2.105 -.608 2.126 -.464 2.072 c
-.32 2.016 -.299 2.006 -.265 1.95 c
-.233 1.895 -.221 1.883 -.177 1.829 c
-.134 1.772 -.1 1.807 -.012 1.772 c
.076 1.739 .099 1.783 .131 1.693 c
.164 1.607 .241 1.65 .164 1.484 c
.087 1.318 -.055 1.283 -.111 1.153 c
-.167 1.02 -.155 .942 -.155 .842 c
-.155 .741 -.167 .676 -.221 .566 c
-.276 .453 -.199 .532 -.403 .343 c
-.608 .155 -.795 .044 -.815 -.057 c
-.838 -.154 -.905 -.2 -.838 -.243 c
-.772 -.288 -.739 -.255 -.696 -.345 c
-.649 -.433 -.597 -.441 -.597 -.531 c
-.597 -.619 -.331 -.401 y
0 0 l
f
Q
EMC
EMC
0 0 0 rg
/GS1 gs
62.022 139.691 490.167 .28348 re
f
62.022 75.061 490.167 .22678 re
f
62.022 121.72 490.167 .22678 re
f
BT
/F4 1 Tf
8.9663 0 0 8.9663 62.022 146.3811 Tm
[(Table)-306.5(1.)-500.5(Doses)-300.8(for)-300.7(Both)-303.4(Cannabis)-299.1(and)-302(Tobacco)-304.1(and)-302(Their)-303.4(Matched)-303.1(Placebos)-309(Used)-299.5(in)-297.8(the)-303.4(Four)-300.5(Study)-303.3(Conditions)]TJ
/F2 1 Tf
7.9702 0 0 7.9702 62.022 127.7858 Tm
[(Drug)-12701.5(Condition)-24242.1(Description)]TJ
/F8 1 Tf
0 -2.1055 TD
[(Cannabis)-9510(Active)-14241.6(66.67)-167.3(mg)-329.3(Bedrobino)11(l)-332.9(\(16.1%)-330.8(THC)-328.4(and)]TJ
/F5 1 Tf
46.2354 0 TD
(<)Tj
/F8 1 Tf
.5335 0 TD
[(1%)-327.9(CBD\))]TJ
-33.4388 -1.1239 TD
[(Matched)-326.5(placebo)-9512.1(66.67)-167.3(mg)-329.3(placebo)-321.9(\(Bedrocan;)-329.6(0.07%)-327.3(THC\))]TJ
-13.33 -1.5009 TD
[(Tobacco)-9824(Active)-14241.6(311)-162.9(mg)-329.3(Marlboro)-327.6(red)-330.3(\(15.48)-163.7(mg)-329.3(nicotine,)-329(16)-160.8(mg)-329.3(tar,)-337.4(0.8)-163(mg)-329.3(nicotine)-326.9(yield\).)]TJ
13.33 -1.1239 TD
[(Matched)-326.5(placebo)-9512.1(311)-162.9(mg)-329.3(denicotinized)-323.1(tobacco)-331.4(\()-81.8(Magic)-329.2(0,)-331.5(0.04)-165.1(mg/g)-326.3(nicotine)-326.8(yield\))]TJ
-12.2061 -2.2477 TD
[(THC,)-302.1(delta-9-)12.2(tetrahydrocann)11(abinol.)]TJ
-1.1239 86.8229 TD
(Hindocha,)Tj
/F11 1 Tf
4.4955 0 TD
[(et)-300.9(al.;)-297.1(Cannabis)-291.4(and)-299.8(Cannabinoi)9(d)-298(Research)]TJ
/F8 1 Tf
17.7544 0 TD
[(2017,)-295.3(2.1)]TJ
-22.2499 -1.2021 TD
[(http://onl)9.4(ine.liebertpu)9.7(b.com/doi/1)9.2(0.1089/can.2)8.4(017.0024)]TJ
59.9708 1.2021 TD
(218)Tj
ET
endstream
endobj
63 0 obj
<>stream
hn0{i
hDqتFJ^Zkkj9
5AIs|3/Mف[;'"Kkv<(,nH[
\4 Y}fAb \pV`c~aF`S) x "1Lg dwv [ Bu]_
(B8Da,mѓVV',jPR(\?+l6Gq/GCPU]ȑsbq1.
mEʪz1;Yյ{hxnU dL 2A+,&i\9 O
endstream
endobj
64 0 obj
<>stream
2016-05-13T14:24:29+05:30
Adobe Illustrator CS4
136
256
JPEG
/9j/4AAQSkZJRgABAgEASABIAAD/7QAsUGhvdG9zaG9wIDMuMAA4QklNA+0AAAAAABAASAAAAAEA
AQBIAAAAAQAB/+4ADkFkb2JlAGTAAAAAAf/bAIQABgQEBAUEBgUFBgkGBQYJCwgGBggLDAoKCwoK
DBAMDAwMDAwQDA4PEA8ODBMTFBQTExwbGxscHx8fHx8fHx8fHwEHBwcNDA0YEBAYGhURFRofHx8f
Hx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8fHx8f/8AAEQgBAACIAwER
AAIRAQMRAf/EAaIAAAAHAQEBAQEAAAAAAAAAAAQFAwIGAQAHCAkKCwEAAgIDAQEBAQEAAAAAAAAA
AQACAwQFBgcICQoLEAACAQMDAgQCBgcDBAIGAnMBAgMRBAAFIRIxQVEGE2EicYEUMpGhBxWxQiPB
UtHhMxZi8CRygvElQzRTkqKyY3PCNUQnk6OzNhdUZHTD0uIIJoMJChgZhJRFRqS0VtNVKBry4/PE
1OT0ZXWFlaW1xdXl9WZ2hpamtsbW5vY3R1dnd4eXp7fH1+f3OEhYaHiImKi4yNjo+Ck5SVlpeYmZ
qbnJ2en5KjpKWmp6ipqqusra6voRAAICAQIDBQUEBQYECAMDbQEAAhEDBCESMUEFURNhIgZxgZEy
obHwFMHR4SNCFVJicvEzJDRDghaSUyWiY7LCB3PSNeJEgxdUkwgJChgZJjZFGidkdFU38qOzwygp
0+PzhJSktMTU5PRldYWVpbXF1eX1RlZmdoaWprbG1ub2R1dnd4eXp7fH1+f3OEhYaHiImKi4yNjo
+DlJWWl5iZmpucnZ6fkqOkpaanqKmqq6ytrq+v/aAAwDAQACEQMRAD8A9U4q7FXYq7FXgf54fmcb
uaTyvo0xFtA1NUuUNPUkX/dKkfsqfteJ27b5WHF1Lz/amuv93A+/9TEfys/MG68qa9EtxKzaJdsI
76CpKoCdplHZk706ivtlmXHxDzcPs/WHFOifQfxb33V/zY/L/S1b1tYhnkAqIrUm4J9qxclH0nMU
YpHo9Dk12GHOQ+95JrX/ADkT5nm1IyaRa29rp6H93DOplkceMjBlpXwXp4nLxpxW7p8vbM+L0gV5
vZPy+85QebvLcOqpH6M4ZoLuAGoSZACwU+BDBh88x5w4TTutJqBmgJBkmQcl2KuxV2KuxV2KuxV2
KuxV2KuxViP5r69faH5E1K9sGMd2QkMco6p6zhGYe4UmnvlmKNypxNdlOPDKQ5vH/wAkvy90vzLP
f6nqxE1taD0I7XqTLKp/ePXso+z/AJXy3yM2QjYOm7L0kclzlvTXlT8rYfNeg31klyLHzDoN7Lay
l1LRyQk1UOB8SkSCSh/zAll4TfQpwaAZoGN1OEiFnmP8lh5X8vXWs65rEZ9IBLa1tYyTLM+yJzcr
TxPwnauGObiNAMc3ZgxQM5y5dyKs/wAtbbT/AMntV17UuMeqX0UM9qZNvShWVWRBX9qb+nvgOS5g
BnHRCOmlKX1EX+z4p1/zjXqUpj1vTCpMSmG5RuwZgyMD8wq/dkdQORbuxJ7Sj8Xt2YzvHYq7FXYq
7FXYq7FXYq7FXnX54ebtV8veWIE0uRre71Cb0TdJs0caqWbi37LHYA/Pvl2GAJ3dd2nqJYsfp5k0
8I0++89aFBaeaLSe5htrqRhFeBzJHI8bFWSUVYdQfhcb9RmSRE7Oghkz4wMgJo/jd6jJ+cvlHzR5
OvdI8yq+n3tzCYnMcbSwmQfEkqceTDi4DcW+85T4Momw7b+UsWXGY5PSSxT8gtclsPPK6fy/0fVY
ZInUmg5xKZUb5/Cyj/WyzPG424XZGXhy8P8AOH3PQ/JiHTfzr83aapIivIEvqdixMbk/fcNlE94A
uz0/p1WSPeAfx80BqyP+Z/n5dMgc/wCEvLj1vZlO085NCq+PLjxB7KGPcZIeiN9S15B+ZzcP+Thz
8yu/5yPnlh8u6RaRNwt5Lli8S7A+nHRdh2HLHT817ZJGMDzTr8hdGsrPyDb38S/6Tqkksty56/up
XhRR7AJX5k5HOfU3dlYwMII5yv8AU9Gyl2TsVeP+e/z7Gj6zNpehWcV6bVjHc3czN6fqA0ZEVCCQ
vQmvX8ciGCxZdPq+1RjlwxF08l1/8yPOeu331u51KaHgSYYLV2hjjH+SqEfean3zIjjiHTZtdlyG
7I92z3L8jfOOqeYvLt1BqkzXN5psqp9Zfd3ikWqcz3YFWFcxc0ADs7/szUyy4/VuQXpGUuydirsV
dirxn/nJWaQaXocIP7t553Yf5SIoX/iZzI0/Mul7aPoiPNKfyj19bRLTyjr6R3Wg+YoWm031FDKJ
TI0bwt7M8TU7hqeOSyxvccw19n5eEDHPeExt+kMn1L/nHbyhc3EktneXdkr1KwApIiE/y8l509i3
05AaiTkT7HxE2CQlv5f/AJJa35e86w6rf3VvNYWPqNbtEX5ys6FEJQgcKcqn4jv44cmYGNNej7Ml
iy8RIICTfnbeax5d/MCLV9Lna2k1HTvRaZQK9WikUVruF4kEdDksIEo0WntOc8WYTjtcael/k/5Z
XQfI9krrS71AC9uj3rKAUX/Yx8RTxrlOWVydn2fg8PEB1O5eO/ntqV3e/mFJp08pS0sY4IrcNsii
VFkd9vd9z7ZkYBUbdL2rMyzcJ2Ar7eqcWv536d5Y0m38v+WtM+t2dghjjv7qQp6rklnk9FRUB3Yt
9v7sj4JkbJbx2pDFEQxxsDqwnVPzN/MLULo38msXVurMfTjtpGghFKfCEQgNTbrU+OWjFEbU4GTX
Z5Hi4iPdsGQXn56+Zrnyf+h2JXV3YxzaslFY29OwA2kO4LCm3vvkBgHFfRyZdrTOLh/j7/x1RX5J
eTNOvfM8r69bs1xb2q3lnZTIDHJHKeHqyBq1oCCoI3rXBmnts2dmaUcdzG9WB72P+cdT0qXzF5lv
YoIvS9Q6dpEEahI0VDweZFAAoI4z9MgOSgDQDRqckeOcv82P6T+O96V/zjfpF3b6Lq2qSqVt7+WK
O3r+19XD82HtWWn0ZVqDvTsOxsZEDI9T9z2HMd3LsVdirsVee/nrocepeQri6p+/0uRLqI9+Jb05
B8uL1+jLcMqk6/tTFx4T3x3eO+VNFv8AzH5Jvo9NYnWfLV0uoWKL/eNDOtJUj91eBXHv88yJnhlv
yLptNjllwkR+vGbH4+D3T8svP1v5v0JZXKpq1pSPUIBt8VNpFH8r/gajMbJDhLvdFqhmhf8AEObM
Mrcx5N/zkXo6XHlax1QD97YXPpk/8V3C0b/hkTL9Od6dT2xjvEJfzT9707R5Fl0mykWoV7eJgD1o
UByku0idg8V/5yG8qX0uqafrllZyTRyRG2u5IlL0dGrHyAr1DEA+2ZOnmORdH2xp5SIlEX0Kl+Wv
kPTtF8t6n5t86aaj28cQezs7qMM3BdyxjcdZGKqoYfgccmQk1FdDo448ZyZR82J3mqRro115m1C3
j/SOtiew0KwRAlvaWgHpzyoigLtzMcf+VybrkwN6HRxJ5fQckh6p2IjuHVPPyX/K6DXpP0/rMfPS
reTja2x+zcSL1Lf8Voe37R27HI5stbBt7M0An65/T082R+efMp8j/mt+mXhaS01DSDCsaAEc1JCC
h47B4krv0P0ZCEeKFebl6rP4Go4j9JhTwya4MsKhzWQySSOafzhd/wDhcygHn5Tsedn9D1HRvz9v
NG0ux0uy0SAWdlBHDRpX5MyKA71AAHNqt0yg4LN27bH2vwRERHYDvZt5P/PzR9c1a30u+0+TTZ7t
1it5RIJ4zI5oqseMbLyOw2OVzwEC3O03asMkhEjhJep5Q7V2KrJ54beGSeeRYoYlLyyuQqqqipJJ
2AAxQTTyzzH+eH5dXdte6LIt7d2t3FJbS3MEKenxkUoWX1JI32rX7OXxwy5uqzdqYDcDZB2eO+Rf
Oc/k3zML+2P1uzasF1GKr6sBINV5fZYUDLX5ZkThxB0ul1PgZLG8f0M+1wW0t7/ysT8tbnlcRfHr
ekqpEiht3d4BuUanx02/aB6kVD+bJ2eUAnx8B3/iH7Px3vVPIXn3SfOGki7tCIryIBb2yY1eJz/x
JG/Zb+OUTgYl2ml1Uc0bHPqED+clmLr8t9ZWlWiSOZT4enMjH/hQcOI1INfaEOLBL8ckx/Li++u+
Q9CnrU/U4o2PiYV9M/imDIKkW3SS4sUT5BkeQch5R+f2tudK0/ytZ/Hf6xcIzRDr6aNRAR/lylaf
6py/AN77nU9q5PSMY5zP4+15b+Z7Ws/mu00DSWWa20e2t9Kt/T6NKu8n+yMjkH3y/Fysuq19SyjH
HlECLPvKN/P+W3nubyjqcxbQdVKzadcvULHJJspqexI9N/cA9MpkOON9XY4JflsvhH6Jckf/AM5G
2VhJ5d0y5b/jpJd+lagfaaORCZBT5on+Zwac7s+2IA4wf4r2TLRPyO8pw+VI9M1aEz38hE91fI3C
RZeJHFGFRwSpFDUHrgOY3YbcfZmIY+GQs97CNa8w/k55Ys7jSNG0WPzBeglXvbkK6BxUf3zDkaHt
GoU+OWRjOW5NODlzaXCOGMRM/jr+pj/5NeUJ/MHnGC+kjpp2lSLd3DgUUyKeUMY7buK0/lByeadC
nG7N05yZeI/THf49H1DmE9S7FXnX593d3b/l9KtuxVbi5hhuCO8Z5NT6WRcuwD1Ou7VkRgNeTyf8
uvI/k/zTo97aT6m8PmtvUOnWleCcUQFSeS0fk1eQDVA+/L8k5RPk6jRaTFlgQT+86fjqxjQZNCsr
270/zRZztbODEz2/Fbq2nRqc157HuGU9fmBk5Wdw4uEwiTHKNvtBbmkby5q0Oo+W9ZFwgJa2uouU
Uyjuk0L7j36qfE4j1CiFl+5kJY5X9/xD0aPRdVk0yy/MzyKogvmVjrGjQglDIjcZ/TQdUcryMfYb
rlNj6ZO08ORiNRh59Y/ezE/mV5X84eQNaiadLHUTp9ws9jOwVlf0mo0ZJX1F5dKb+IGV+GYyDmDW
Y8+GW9HhOyM/Im8+sflzZRk1NrNPCf8AkYZB+EmDMPUy7LleAfH7078+ee9J8n6T9cvP31zLVbKy
U0eVx1334qtfibt88jCBkW/VaqOGNn4B88+bbzzULqDzZrZNvq2sBm0yIVVoLZFCiRVP2AQ9I+/V
utDmXADkOQee1MsgPiz2nLl5D8frTP8ALrTfLHl+S282ebb1Iin77SNLSslxIw+zO8a1KqOqcqVO
/wA45CZbBs0WLHirLlPuHX3sm85efPy5/MKwGlMbjTdUiJbS7+8jRIhKdvTd0eQqklACWAA2PbIR
hKG7lZ9Vg1I4NxLoSwrRdX8w+avOHljRdbna4TTLlIVVvtcEkDS82H2m4x8eXtlsgIxJHVwcWXJl
ywhP+E/j7np/5nedtQ1PVYvIXlWTnqF63paldRnaJCKvHyHSi1Mh7DbrXKMcABxF2ut1MpSGHH9R
5nueMXuhWN350j8v6HJ69s1xHYwXR39VqhHmPahfkwp0X78yRIiNl0c8MZZvDhyuv1l9WeW/Leke
XdKi0zS4RDbx7seryOftO7d2b/a2zAlIk2XrcOGOOPDEbJngbHYqlHm7y5beZPLt9o1weC3UdI5K
V4SKQ0b/AOxcA5KMqNtOfCMkDE9XyPqulaz5c1qSyu1e01GykqGUlSCDVZI2FNj1VhmeCJB4/Jjn
inR2kHsHk/TvJ/5p6VKdahNv5rslVbu+tiIpJk6JMVoUc7cWqu3sCMx5mWM7cnd6eOLVx9Y/eDmf
0pfqn/ONuvJN/uK1a1nhPe6WSBh7fu1nB/DJDUDqGnJ2LL+GQ+P4L1z8vvKP+FPK9tpDTC4nQvLc
SqCFMkhqeIO9BsPxzHnLiNu50uDwsYjzY1+Yn5MaR5kMuo6WU07WmqztSkE7f8WKPssf51HzByeP
MY+5xdZ2bHLuNp/jmkP5H6smgeXPM9vrL/VotEuvUuw3VGKmN19zyhoB3OSzCyK6tHZc/DxzEv4T
ut8gaLcfmB5pu/PHmGHnpkLmLSLGT4o/gOw4kUZYx1/mffscZngHCF0mM6jIc0/p/hH4/FpL/wA5
JQTDzFpM5U+g9myI/YukrFh8wHXJ6fkXH7aB4onyY3+X/wCV1z5os7jWL6+TTNCs2Kz3T7u3pqGf
jWihVWlWJ2998nky8Ow5uLo9Aco45HhgG/zI8o+UdI0vQtV8s3s13Y6os68pjUsbZlVnHwpT4moR
THHORJBTrtNihGMsZsS/QxfQYPMMt7Jd6Mbhbqziknnu4GZGhiCkSSNIpHBeJIJrk5EVu4eGOQyu
F2Ovd8VKHV7q1tprezYwm5BW7uFP72RSa8OXVU8VH2v2q7APD3qMxiCI9eZ6n9j1H8j9L8j2+ox6
nqWsWz66KiysGLRiIsOJJaRUWSQ12CEge56UZjLlWztuy8WIHiMhx9z6BzFegdirsVdirAfzp8t6
TqXku+1C4gDX+mxeraXIFHX4hyWo6qRXY/PLcMiJOB2jhjPESRvEbPAfJN9r+i3cnmfSE9RNJeIX
8Q/agn5AhwP2DwoW7ErmXkAOxed0kpwJyR/h5+4vqry55h0zzDo9vqunSepbXC1ptyRh9pHA6Mp6
5gSiQaL1uLLHJESjyKZYGx2Kvmbz/wCXtRl/Ni+8v2Mrxxa5dQSsgYrG3rAOXdQaN6bs5zMxyHBf
c8zq8MjqTAcp1+PvfR2kaVZaTpltptjH6dpaRrFEnei9z4k9Se5zEJs29JCAjERHIIHzV5d8r63p
3DzFbxTWVsTN6krtF6dBu3qKyMop13wxkQdmvPhhkjUxYeTajfyed5YvI3kW1+peUrR1/SOoqCsb
IG5UFd6FtwD8TtvsK5eBw+qXN1U5nOfCxCsY5n8fg+5if503emRa7Y+XdKoNP8v2q2qqCDSVjykq
R+19nl/lVyzCDVnq4XasoiYhHlAM4/ITyzb3fknXXulIi1l3sXK7MYVi4mh+czZVnl6h5Od2TgBw
yv8Ai2+DDrn8gfPaaq9rbpBLZBqR6g0qqhSuxZN5AadRxP05aM8acKXZGXioVXexXzp5e0ny/qi6
ZZaoNUuIVpqEiR8Io5gd40bk3OnfYU/AThIkXTh6vDDHLhjLiPV9OflrJqknkTRX1QML0245c68i
gJERau9THxJzCyVxGnqtIZeFHi50yXIOS7FXYqhtS0+11LTrnT7tedtdxPDMvcpIpU0998INMZxE
gQeRfL2r6P5r/LLzOzoOVvJzjgndedvd27fajlToaj7SHofoOZoImHlsmPJpMljl9hCa+U/Nd9oN
zca75ThebRTSTXPLzsXNvXb1EbcmP+WSlV+y/YtGUb2PPvb9PnMLniFw/ij3e78e97v5R87+XvNV
l9Z0q4DSKKz2j0WeI/5aV6f5Q298xZQMebvdPqYZRcSn2Rb3lnnaCLT/AM5vJ2sSqPSvUksqnvKA
6KfnW5WmXwNwIdXqYiOpxy77H4+b0fWNY03RtNn1LUp1t7O3XlJI34ADqSTsAOuUgXsHY5MkYRMp
GgHiuo6tqP5gl9V169/w7+XdpLRFZuMl0yn7IG/qPt2BC9gTXMgDg2G8nTSnLUeqZ4MI+1K/MP5y
WljpZ8v+QrL9FaagK/XiKTNUUZkFSVY/zsS3yOSjhs3JozdpiMeDCKHexJvJGo2/kybzbqh9KC5d
ItMiY1knklarSN4KEVyO5O/TrZxji4Q4f5SQxHLLry876vU9A/MXQfJX5Z6NZw8b7XLiFpYbCEhj
zmkZw0xUniPipT7R6D2oljMpHudvi1cMGCI5yI5e95V5o88+c9VmaPVNYmkJr61pC3pwIenHhHxR
iO+x+fXL4QiOQdRqdVlkalL4Dkz78ofyea7aHzD5kgK2go9hp8goZe4llU/sfyr+11O3WrLm6B2H
Z3Z38eQe4fre9gACg6Ziu/dirsVdirsVee/mB+YX5Zxx3Pl/XmOonpcWsCGQxuOnx1VVdfZqjLYY
5cw6/VavALhM35PHfyduDD+aGnpY8mtp2uIuLbFoPRdhz+XEN9GZOYejd0vZ0q1AEeRv5PV/Nn5N
QTXv6b8oXR0PW0YyBYyUgdup+zvHXvQFf8nMeOXodw7fUdngnjxngn9iE8v/AJu6jpGoDQPzCtG0
+/XaPUlX91IOgZwtRQ0+2nw+wwyxXvFji7QMJcGYcJ7+ha/P1ifLmia9YSLIbO+R4J4yGWkiF1cM
Oo5RL3xwcyEdqkjHGY6SDHk1W/8Azf8AOVtZcJLXyppipcXVvWhLUoeRHV3YlF8FqetcnXhjzccZ
DrMgHLHHcvO/PPmqTzBrTvEPR0i0rBpNkg4xw26bLxUbAsBVv6AZdjhQ83V6zUeJPb6RyHkkQhnW
IO0BKTbRSFWoSDT4CKA9KZK2gRNcuaKuL7XZra30a4nuHt7d/wDRbCRn4o8n8kbdOXL8cAA5s5Sy
ECBvbo9L13yFp35feR31K+kW4816gVt7ShHC25ispiX9plSo9TsSKU70iZnKujtcmljpsXEd8h29
3u/WrfkR+XdhqzS+ZdVjE9vaTejZWriqNKoDGRgeoXkKDx+WOfJWwXsnRiX7yXTl+t9AZiPQuxV2
KuxV2KuxV8dtpkGl+bm0/wA2R3CxQ3BTUfRYLNQn+8Usrhga8v8AKHQ982F3H0vGHGIZay3z3fRf
kL8u/IGkSjWvL8h1CVgVhvmnEwQMKMqcOKAkHeormHPJI7F6bS6PDD1Q387tnOVualHmfypofmbT
WsNXtxNFuYpBtLEx/bjfqp/A96jJRkQdmnNghljwyFvnjz75R86+S7CfSWupLvyndyK8UgHKIOp5
KHUhvRk2/ZI5eJ3Ay8coyN9XndXp8uCJjd4j+Pg9A/5xwtbT/C+rT0BuJrz0pgR1jSJSn4yPlWo5
uw7FA8Mn+l+gMc1L8gJ7HULm+vdZtLTyzC5lkuGLidIa148CvDlT4R8f0dsmM+3Ldxp9kVIkyAxr
9T/OLV7TSXt/JWmJZeWtNC2kV/OjO5ZhROO4RWO7UbkT1PhgGEX6juyydoyET4Uaxx2svL9O1Uxa
3FrN+WvJop1umR2JaaVW5/G3XiWHxHr4ZeRtQdTjyVPjlubv3lk1pYed/wA0/MpnkYuFIWW4IK21
rETXio/UvU/jkCY4w5UYZtXOzy+wPpTyx5esfLuhWmj2VTBapx5t9p2J5O7U7sxJzDlKzb02HEMc
BEcgmmRbXYqpXV3a2kD3F1Mlvbxisk0rBEUeJZiAMUEgCyx7SvzB8v6zrP6L0Qyam8Y5Xd3Av+jQ
rvTlK/EMWIooStfvyZgQLLj49VCcuGPq+75smyDkuxV5T+e/kMato/8AiKxirqOmp/pQUbyWo3Ym
neL7Xyrl+CdGnU9q6Tjhxj6o/c8t/K+LXri8ni8tawdN19B6sFpKaW95Gu7Ia1XmvUBlII/lpvfl
rqNnV9niZsY5cM+7oXqemfnNe6Vdppfn3SJdIuugvo0ZoH7cuPxHj7oWyg4r3ibdtDtEwPDmjwnv
6fj5vS9N1TTdTtEu9Ouoru2f7MsLB1+VR0PtlJFOyhMSFg2F9/YWeoWU1lexLPa3CGOaF+jKwoRi
DSyiJCjyeP8A5VXlh5P1bzxpF9Nws9JkFyjt9owxM6lqdyymPbxOX5fUAXUaAjDLJA8om/h+KQln
ba7+bF/LqusTtpXkjT3YxW6sF5lN2JY7VC/ac7L0XvhJGPYfUwjGerPFL04h072OfmZ5+0C50qLy
h5UtEh0GzkDvcgf3rpUDhXfjXcu27frnixm+I83F12sgY+FjHpH4/BSf8qfIkHnDzE9rdyPFYWkX
1i5MY+J/iCrGG/Z5V6+AyeWfCGjs/SDNPf6Q+otK0nTdJsY7DTbZLW0hFEhjFB8z3JPcnc5gk3ze
rhCMRURQReBkxfzL+Zfkzy7zTUNRRrpP+PO3/fTV8Cq7L/syMnHGTycbNrMWL6ju85ufzr84eZb0
6b5I0UiQ/wC75QJZFBNOZG0UY/1ywy7wRHeRdae08mU8OGPz/FJjp/5Ma7rcyX/n3XJ76QfEthA5
KLXtzI4r7iNB88icwH0hsj2dKZvNIy8uj0/RdC0fRLFbHSbSOztV39OMdT/MzGrMfdjXKSSebtMe
OMBURQR2Bm7FWnRHRkdQyMCGUioIPUEYq+cfzJ/KzWfKuqNr3l0StpIf1o3gJ9WzataGnxcB+y/0
H3zMeUSFF5vW6CeKXHj+ny6fsRuh/ntBd2I0rztpUeqWhoHuY0QsaCnJ4X+At7qV+WCWDrEs8Paw
kOHLGx+OiZ2nlrSbiU65+UmvC11EANPockhAdepUpL8X/Bgr4MMiZHlMN8cET69NKj/NZj5G/NO2
1e5Oh+YIv0R5nhb0pLSQFElYf77LdCf5SflXK5463G4cvTa0TPBP05O79TyT8+9KNp+YMk6LtqVv
DOKd2AMJHz/dZkYD6XTdrY6zWP4h+xT/ADE86TRWVt5H0h/Q0jR41tr1ozT6zcxikxYj9gSV27nf
wxxw/iKddqqHgw+mOx83neXOqe1f841XIS8121KNWeO3lSSh40hZ1YV8f3wzG1PR3vYn8Xw/Szzz
l+cnlLy2Xt45P0nqS7fVLYgqp8JJd1X5Cp9sqhiMnYantHHi25y7g8c1X8w/zJ893p07TRLHDJsN
P08Mo4nvLIPiI8eTBfYZkDHGO5dNPWZ9QeGGw7h+ksw8n/8AOO6Dhdearrmftfo61YgfKSbr8wn/
AAWVz1Hc5mn7HA3yG/Ifrew6Touk6PZrZ6XaRWdsvSOJQoJ8W7sfc75jkk83cwxxgKiKCNwM3Yq7
FXYq7FXYqwrzP+T/AJI1/wBSV7P6hevU/WrOkR5eLJQxt7/DX3yyOWQcLP2fiycxR7w8j8x/kR5y
0WU3eiSjVIYzyjaA+jcrTv6ZP/EGJ9syI54nm6fN2Vlgbgb+wsQ1nzLrt4BZeZI3uby1+GK5uFMd
9DTcK0hHJxXtID7EZYIDmHDyaiZ9OQWR15SH480Prnm7XtcaxfVLk3UunJ6VvM6jmVDchzI+0fc7
4YwA5MMuqnkriN8KfflYdMvPzGtn1RI5rWYXbvHOodHLQSGhVqg9enjkMtiOzlaDhlqLl1tjkNpP
Z28GtywKLeWZhYRSjkkrxEF/hP2o46gNXqdt96TJvZxYx4R4hG17D8dAjtT/ADB866pAbW61ac2z
DibaGkERH8vpwhFp7UwDHEdGU9bmnsZH7vuZp+X35F6prAj1HzCX07TTRo7WlLmUddwf7tT77+3f
K8mcDYOdo+ypS9WTYd3X9j3vQ/L+i6FZLZaTaR2luvVYxux/mdj8Tt7sa5iGRPN6DHijAVEUEwwN
jsVdirsVdirsVdirsVdirsVSjzF5R8ueYrf0NYsYrqg4xykUlT/UkWjr9ByUZEcmrLghkFSFvl/8
yPJE3lHzJLYAtJYSj1rCdurRMacWI25IQQfv75m458QeU12l8Gdfwnkp6fZ6PoMlrqOq3C3l6lJo
9GtieQNKoLqcfDFv9pF5N2PHskmWwTjjDCRKZuX80fpPT3KDv5i8563Ba2tv60/AQ2VjbrwhghTo
qL0RFrUsx9ya4dohgTk1EwAPcByAe9/lz+TWkeW1i1DUwt/rgowcisMB/wCKlPVh/OfopmLkzGXu
eg0fZ0cW53n+OT0fKXZOxV2KuxV2KuxV2KuxV2KuxV2KuxV2KvJP+cgvNdha6FF5fQJLqV6yyvUB
mhgU/aBP2WdhxHtyy/BCzbqO1tQIw4P4pfc8T8peUtY806xHpmmR8nb4ppmr6cUdd3c+H6+gzKnM
RFl0Wm00s0uGL6j8j+QtE8oaaLWwT1LqQD63fOP3krD7+K+Cjp7nfMGczI7vV6bSwwxqPzZJkHJd
irsVdirsVdirsVdirsVdirsVdirsVY558866f5R0KTUbmklw9Y7K1rRpZabD/VHVj2HvTJwgZGnH
1WpjhhxF8vww+Y/PHmugrd6rqUvJ3OyIvdjSvGONfuGZu0A8oBk1GTvkX1D5G8k6X5R0VNPsxzne
j3t0ftSy0oT7KP2V7fOpzCnMyNvV6bTRww4QyLIOQ7FXYq7FXYq7FXYq7FXYq7FXYq7FXYqgta1j
T9G0u51PUZRDZ2qF5XP3AAd2Y7AdzhAs0GGTJGETKXIPlDzt5v1Xzp5jN5IjcGYQ6dYpVvTQmioA
PtOx+0e59qDM+EBEPI6rUyz5L+QfQf5U/l1D5R0YS3Kq2t3qhr2QUPpjqIVPgv7XifamYmXJxHye
j0GjGGG/1HmznKnOdirsVdirsVdirsVdirsVdirsVdirsVcSAKnpir5m/OX8xm8y6sdL0+Wuh6e5
CFTtPMNml91G4T7++ZuHHQs83mO09b4kuCP0j7SyT8g/y+Esn+LdRj+CMsmlRMNiw+F59/5fsr71
PYZDPk6ByeydH/lJfD9b3XMV3zsVdirsVdirsVdirsVdirsVdirsVdirsVeZfnl56OhaCNGspOOp
6srKzD7Udt0dvm/2R9Phl2GFm3Wdqarw4cI+qX3PCvIvlO681eZLXSYarE59S7mAr6cCfbb59h7k
ZlZJ8It5/Sac5sgj06+59eWNla2NnBZWkYitrZFihiXoqIKAfdmvJeyjERFDkGMaj+bH5eaddtaX
WtReup4uIklmUEGhBeJHUU+eWDFI9HFnr8MTRkLcn5sfl0yhhrkFD4hwfuKg4PDl3J/PYf5wZRa3
Vtd20V1ayrNbzKHilQhlZWFQQRkHJBBFhVxS7FXYq7FXYq7FXYq7FXYq7FVC+vbawsp726cRW1tG
0s0h6KiDkx+4YQLRKQiLPIPj/wA5eZrrzL5jvNYnqBO5EER/3XCu0afQvX3zYQjwinjNVnOXIZH8
B77+Rnkv9CeWRqt1HTUdXCy7jdLelYl3/m+2fmPDMTNOy9F2ZpvDx2fqkl358fmBNpVjH5c0yb07
2+QvfSIfijtzsE26GTf6PnhwY7Nlq7V1Zxx4I/UfueGXejyWmlW9689nMt2VKRw3KSXEWxNJIUaq
V78l+7MoSsugli4YA3E357j4KeiaQ+rX62a3VrZcgWNxezLbwqB4u3f2wyNMcWLjNWB7zTLD+Wvm
15Y7bTdW0/Uo1VRE1pqMJT4iTxRXZG6n+XKvEj1DsBoc2wjIEeUkS/5Xfm9pw9aC2uARuWtrtC23
ssnI/QMfEgUnRaqPK/hJfpn5q/mX5UvltdXaa5RCPUstTRvUK+IkYCX5GpHticUZclhr8+E1Pf3/
AK3vXknztpHm7SBf2BKSIQl3aOavC57HxB/Zbv8AeMxJwMTRd/ptTHNHiiyDIuQ7FXYq7FXYq7FX
Yq8f/wCchfOH1PSrfy1avS4v6TXtDutujfAp/wBdx9y++ZGCFm3T9r6nhhwDnL7nkn5ceVW8z+br
LTWBNqG9e9YdoIt2/wCCNEHucyMkuGLptDg8XKB05l9W3Gs6JY2rzT3tvBbW61djIiqqr9OYFF68
ziBZOz5H84eYX8w+ab/WJeXp3MxMSV3WFfhjXp1CAduubCEaFPG6nN4mUyPK/sV/Nf8AhH0rL9AW
GoWbMhad790YSAgcTGFG/ffb5YIcXUs9V4VDgjKPvQ/lddEa8catpt5qcdB6cNlII2B7lhwct9BG
M76FjpRAn1RlL3Pavy90byNe6hGsXkW/0+WMGRb7UEklgDpuPimanLwovXMbIZd7vdJjxE7Y5R85
D9b13KHbJP5q8q6R5m0mXTtShVw6t6E9AZIXI2eM9iPx75KMiDYac+COSPDJ87+Q9YvPIP5itZak
/pW/qmx1MH7HAn4Jfkpo4P8AL88y5jjjYec0mQ6fPwy5cj+gvqBWVlDKQVIqCNwQcwnqXYq7FXYq
7FXYqpXd1BaWs11cOI7e3RpZpD0VEBZifkBigkAWXx55w8x3HmPzJfaxNUfWZCYUO/CJfhjT/YoB
mxhHhFPF6rOcuQySmGCaeVIYI2lmkPFI0BZmJ7ADc5IlpjEk0OafX/5feddP05tSvdHuYLNPtyOu
6g92WvJR7kZAZIk1bkz0WaMeIxNJDDE80qRJQvIwRQSAKsaDc7ZMuNGJJoPRvzJ8ofmTZ6LZ6l5o
1OLULS3IihRZi7xGQDqGSPkTx3ILZRjnG6AdprtPqBASySEgPx3JF5AvPM8d5NbaJr1voYk4tNJe
XCW8TkVC7OG5EV7KcnkA6i3H0U8lkQmI+8vfvIMvm1rh/wBN+aNN1uMxkJBZCNnDAj4ucYi2HT7G
Yk66Cno9L4n8c4y934/QzfK3Mdir5j/Om7t9X/Mia106ANPEsNk7JXlNcD+I5iP/AGOZuEVHd5ft
SXHn4YjfYfF9BeS9GvNF8q6ZpV7MJ7q0hEcsgJIrUnipPZQeI9hmJM2bei0+MwxiJ5gJ1kW52Kux
V2KuxV5V/wA5AebP0d5ci0K3el1qxrMAd1t4yC3/AAbUX5Vy/BCzfc6rtbUcGPhHOX3PnWKOSWRI
o1LyOQqIoqSxNAAB3OZjzABJoPqf8r/y2sPKekxTTxJJr1wga7uSAxj5D+6jPZV70+0fopgZMhkf
J67RaOOGP9LqWcMqspVgCpFCDuCDlbnPkz81PKv+G/Od7aRR+nY3B+tWIAooilJPEf6jVX6Mz8Ur
i8h2hp/DykDkdwsuW8izeVI2bUdVl8xxoONtIsZtFeu6rX4gtO/KvtiOK+QpMjhOLeUzPu6JP5fn
8vQXxfXbS4vLPieMVtKsLc6ihYlWqtK9KZKQPRx8EsYl+8BI8nrPk3zV+XNpf29zoPkjUpLyP7Fx
CjXci1BVmXlI3ifDMecZdSHdabPhBBhjl76v9L3G2m9e3im9N4vVRX9KQcXXkK8WG9GHfMZ3YLDP
PH5s+WfLNrKkVxHf6vQiGxhYPxft6zKaIB3HX2yyGIycPVa/HiHO5dzyP8lvLt75i88nXrxTJbaf
I13czMNnuZCTGB/lczz+jMjNKo06fszCcmXxDyG/xfSeYb0rsVdirsVdirsVfI/5meZz5j85X9+r
crWN/q1l4ejCSqkV/mNX+nM/FGovH6/P4mUnoNgn35EeWhq3nRb6ZOVro6fWWqKgzE8YR8wauP8A
VyOeVRrvcjsnBx5eI8o/e+mswnqHYq88/OfyFN5n0BLrT4/U1fTCzwoPtSxMP3kQ8W2DL93fLcM+
E+Tru0tIcsNvqi+erPXdRtdMudCMdrHBcOfWkntommRhsR6pQyL0+jtTMsxF287DNIROPYA94Su2
uZra4juIG4TRMHjagNGG4NDUZMi2iEjE2ObMH/MD8yb+0jp5gkHOQJHDFNHDMTQjpHwanzyrggOj
njV6iY+v4bAo1fI/5ya6o9eO/uonH27u7HArtv8AvZNxv2wccAz/ACurnz4vjL9rJfLX/OOmpSSp
N5ivo7eAGrWtpWSRh4GRgFT6A2QlqO5ycHYxu5n4B7XoehaVoemxadpduttaRfZRepJ6szHdmPcn
MYkk2XeY8cYR4Yigj8DN2KuxV2KuxViP5reY/wBA+RtRukbjdXCfVLU9/Un+Go91Tk30ZZjjcnE1
2bw8RPV8mZnvHPpb8gvL/wCjfJX6QkWk+rStNU9fSj/dxj8GYfPMLPK5PU9lYeDFfWW70vKXZuxV
2KpLq3krylq9x9Z1LSbW5uNqzvGvqGnTk4ozfTkhMjkWnJp8czcogn3K1j5V8sWAAstJs7eneOCN
T9JC1OAyJZQwwj9IA+CZoiIoRFCqooqgUAHsBgbG8VdirsVdirsVdirsVdirwH/nI3zCZ9W0/QYn
rHZxm5uFH+/ZfhQH3VFr/ssytPHq8/21msiHxeSafZT399bWVuvKe6lSGJRvV5GCqPvOZBNB0uOB
lIRHV9n6Vp1vpmmWmnW4pBZwpBH/AKsahQT92a4m3uIQEQAOQRWBk7FXYq7FXYq7FXYq7FXYq7FX
Yq7FXYq1JIkcbSSMFRAWdjsABuScVfG3m7XX17zNqWrsSRdzu8QPURA8Y138EAGbGEaFPFarN4mQ
y7yyv8i9C/Snn23uHXlBpcb3b16cx8EY+Ydw30ZXnlUXM7JxcWa/5r6fzCepdirsVdirsVdirsVd
irsVdirsVdirsVdirC/zg1/9DeQdRkVis96osoKbfFPUPv7RhzlmKNycLtDNwYZHqdvm+Usz3kH0
P/zjroX1Xy1e6xItJNRn9OI/8VW4I2+bs33Zh6iW9PS9j4uHGZfzj9z1rKHbuxV2KuxV2KuxV2Ku
xV2KuxV2KuxV2KuxV4F/zkfr4m1XTNDiaq2kbXNwAf25jxQH3VUJ/wBlmVp48y8/21l3jD4vHERn
dUQFnYgKo3JJ2AzJdGBez7K8o6Iuh+WdM0kABrS3RJaUoZaVkO3i5JzXSNm3t8GPggI9wTbItrsV
dirsVdirsVdirsVdirsVdirsVdirsVfLOu6H5v8APnm/U9V0rTZ7q2uZ2FtcFfTh9FPgi/euVj+w
o75nRlGMaLyufDl1GUyiDX2Uzz8vvyGvdO1a01fzFcQt9VYTRafDV6yLunqOQB8J3ota+OVZM9ig
5+j7KMJCUzy6PasxnduxV2KuxV2KuxV2KuxV2KuxV2KuxV2KuxV2Kv8A/9k=
2016-05-13T14:24:29+05:30
2016-05-13T14:24:29+05:30
False
False
1
841.890625
595.280273
Points
Cyan
Magenta
Yellow
Black
Default Swatch Group
0
PANTONE 7718 C
SPOT
100.000000
RGB
0
116
115
application/postscript
converted
from application/postscript to application/vnd.adobe.illustrator
saved
xmp.iid:4DA2E44DE818E6119D84ADE932358297
2016-05-13T14:24:29+05:30
Adobe Illustrator CS4
/
xmp.did:4DA2E44DE818E6119D84ADE932358297
xmp.iid:4DA2E44DE818E6119D84ADE932358297
xmp.did:4DA2E44DE818E6119D84ADE932358297
endstream
endobj
66 0 obj
<>stream
/GS1 gs
BT
/F7 1 Tf
10.959 0 0 10.959 59.7543 697.8896 Tm
0 0 0 rg
0 Tc
0 Tw
(Scale)Tj
8.2191 0 0 7.3052 81.5244 702.7651 Tm
(26)Tj
10.959 0 0 10.959 89.4047 697.8896 Tm
[(;)-268.3(\(ii\))-263.2(t)-8.4(r)-13.6(e)-8.2(a)-7.9(t)-8.4(m)-10.5(e)-8.2(n)-7.4(t)-8.4(-)-8.1(s)-13.6(e)-8.2(e)-8.2(k)-7.6(i)-9(n)-12.5(g)-271.4(f)-9(o)-7(r)-277.5(c)-8.2(a)-7.9(n)-7.4(n)-12.5(a)-7.9(b)-7(i)-9(s)-277.5(o)-7(r)-272.3(t)-8.4(o)-7(b)-12.1(a)-7.9(c)-8.2(c)-8.2(o)]TJ
-2.7056 -1.1847 TD
.0084 Tc
[(use,)-353(or)-351.8(curr)-5.2(ently)-351(u).7(s)-5.2(i)-.6(ng)-351(nicotine)-351.6(replacement)-351.8(t)0(he)-5(rapy)]TJ
0 -1.1795 TD
.0091 Tc
[(or)-444.3(other)-444.3(cessation)-448.3(pharm)9.1(a)-4.2(cotherapy;)-445.4(\(iii\))-444.6(smoking)]TJ
/F5 1 Tf
0 -1.1847 TD
0 Tc
()Tj
/F7 1 Tf
.5949 0 TD
.303 Tc
[(1)295.7(0).9(c)294.8(i)294(g)295.4(a)295.1(r)294.5(e)289.6(t)294.6(t)294.6(e)294.8(sa)5.4(d)290.2(a)295.1(yo)296(rs)294.5(c)294.8(o)296(r)294.5(i)294(n)290.5(g)]TJ
/F5 1 Tf
12.3173 0 TD
0 Tc
()Tj
/F7 1 Tf
.5897 0 TD
.3022 Tc
[(4o)295.2(nt)293.8(h)290(e)4.3(F)289.4(a)294.3(g)294.6(e)294(r)293.7(s)288.6(t)293.8(r)293.7(o)]TJ
7.051 0 TD
.0602 Tc
(m)Tj
-20.553 -1.1795 TD
.009 Tc
[(Test)-552.9(of)-548.4(Nicotine)-547.6(Depe)-4.4(ndence)]TJ
8.2191 0 0 7.3052 199.1621 650.9479 Tm
.0107 Tc
(27)Tj
10.959 0 0 10.959 207.2692 646.0723 Tm
.0092 Tc
[(;)-548.8(\().4(iv\))-553.1()2.2(rst)-547.5(c)1(igarette)]TJ
-13.4606 -1.1847 TD
[(s)-4.4(m)9.2(oked)-303.7(within)-298.2(the)-299()-3(rst)-304.4(3)-298.1(h)-3(ours)-304.5(after)-299.3(w)-1.8(aking;)-300.5(\(v\))-304.8(s).7(ig-)]TJ
0 -1.1795 TD
0 Tc
[(n)-12.5(i)-9()-7(c)-8.2(a)-7.9(n)-12.5(t)-505(r)0(e)9.2(s)0(p)9.7(ira)16(to)10.5(ry)9.8(,)-495.9(p)0(h)11.2(y)0(s)9.8(ica)16.3(l,)-489(or)-491.4(cl)14.2(in)9.5(ica)11.1(ll)13.7(y)-493.9(d)0(i)9.2(a)0(g)10.4(n)0(o)11.5(s)0(e)9.2(d)]TJ
T*
[(lea)11.5(rn)10(in)9.5(g)-333.5(i)0(m)11.5(p)0(a)10.3(irm)18.5(ent)12.3(s;)-328.5(\(v)9.5(i\))-328.2(cli)15.5(ni)9.5(ca)9.8(lly)-325(di)14.4(ag)10.4(nos)13.4(ed)-331.4(sc)14.4(hi)9.8(zo)10.7(-)]TJ
0 -1.1847 TD
[(phr)13.1(en)10.3(ia)-327.3(or)-325.8(ps)9.7(yc)10.1(ho)11.9(sis)-320.8(\(o)10.1(r)-334.4(a)-328.6(r)10.4(st-)16.4(de)10(gr)9.8(ee)-326.8(fam)13.9(ily)-320.1(me)12.3(mbe)15.7(r)]TJ
0 -1.1795 TD
[(wi)11(th)-331(eit)10.6(he)10.6(r\))13.8(,)-340.7(o)0(r)-331(s)0(u)9.7(b)0(s)10.4(tan)17.7(ce)-332(us)9.7(e)-339.3(d)0(i)9.2(s)0(o)10.4(r)0(d)9.7(e)0(r)14.4(;)-340.7(an)10.6(d)-333.6(\()0(v)9.5(ii\))-326.8(ill)15.1(ici)15.2(t)]TJ
0 -1.1847 TD
[(su)9.7(bs)10.4(tan)12.6(ce)-513(us)9.7(e)-520.3(o)0(t)10.5(h)0(e)10.6(r)-515.4(th)10.5(an)-517.1(ca)9.8(nn)11.1(ab)11(is)-514.1(mo)13.5(re)-513.3(th)10.5(an)-517.1(on)11.5(ce)]TJ
0 -1.1795 TD
[(pe)10(r)-298.2(w)0(e)11.8(e)0(k)10(.)]TJ
/F8 1 Tf
10.4607 0 0 10.4607 59.7543 529.5117 Tm
/Cs8 cs 1 scn
[()45.3(Roll)-299.9(a)-301.4(joint)47.7()-301.6(paradigm)]TJ
/F7 1 Tf
10.959 0 0 10.959 59.7543 516.529 Tm
0 0 0 rg
[(Th)22.4(i)11.7(s)-236.1(pa)20.6(r)12.2(a)12.8(di)19.5(g)13.1(m)-233(wa)22.5(s)-236.1(d)13(es)19.5(i)11.7(g)0(n)21.3(e)12.5(d)-235.3(a)12.8(s)-236.1(a)12.8(n)-235(e)12.5(co)21(l)12(o)0(g)21.6(i)11.7(ca)20.1(l)-231.1(a)0(s)19.8(s)12.2(es)19.5(s)12.2(m)10.2(e)12.5(n)0(t)]TJ
T*
[(of)-181.6(pa)20.6(r)12.2(t)12.3(i)11.7(c)0(i)19(p)13(an)21(t)12.3()11.1(s)-194.7(\()11.9(a)12.8(\))-195(t)12.3(y)13.1(pi)19.5(c)12.5(a)0(l)-182.1(d)13(os)20.8(e)-189.3(p)0(e)20.3(r)-189.5(jo)20.6(i)11.7(n)0(t)-181.3(\()11.9(at)-181.8(b)13.7(a)0(s)19.8(e)12.5(l)12(i)11.7(ne)20.6(\))-195(a)12.8(n)13.3(d)]TJ
T*
[(\(b)20.5(\))-200.2(d)0(e)20.3(s)12.2(i)11.7(r)0(e)19.5(d)-199.1(do)21.6(s)12.2(e)-199.6(1)-203.9(h)13.7(ou)21.6(r)-199.9(a)12.8(ft)18.8(e)12.5(r)-199.9(dr)20.1(u)13(g)-204.2(a)12.8(d)13(m)10.2(i)11.7(ni)19.8(s)12.2(t)12.3(ra)19.8(t)12.3(i)11.7(on)-190.2(o)13.7(f)-200.4(bo)22.3(t)12.3(h)]TJ
0 -1.1847 TD
[(ca)20.1(n)13.3(n)0(a)21(b)0(i)20.2(s)-251.6(an)21(d)-256(t)12.3(o)13.7(b)0(a)21.3(c)12.5(co)21(.)-252.8(G)0(r)21.8(o)0(u)21.6(n)0(d)-242.6(p)0(l)19.9(a)12.8(c)12.5(e)0(b)21(o)-255.3(c)12.5(a)12.8(nn)21.5(ab)21.3(i)11.7(s)-256.8(\()11.9(w)14.8(hi)20.2(c)12.5(h)]TJ
0 -1.1795 TD
[(co)21(nt)20.5(a)12.8(i)11.7(ns)-212.4(t)12.3(h)13.7(e)-220.3(p)0(r)20.1(e)12.5(ci)19(s)12.2(e)-220.3(t)12.3(e)0(r)19.5(p)13(en)20.7(e)-220.3(p)0(r)20.1(o)13.7(l)20.5(e)-220.3(o)13.7(f)-221.1(t)0(h)20.8(e)-220.3(o)13.7(r)0(i)18.7(g)13.1(i)11.7(n)0(a)21(l)-220.8(s)12.2(t)12.3(ra)19.8(i)11.7(n)0(,)]TJ
0 -1.1847 TD
[(with)-247.6(all)-247.7(cannabinoids)-244.2(removed)-249.1(to)]TJ
/F5 1 Tf
13.5796 0 TD
(<)Tj
/F7 1 Tf
.5794 0 TD
[(0.2%)-246.7(of)-248.8(dry)-246.2(weight;)]TJ
-14.159 -1.1795 TD
-.0195 Tc
[(av)4(aila)3.6(ble)-239.8(f)2.5(rom)-237(B)4.8(ed)3.9(ro)4.6(ca)3.6(n)-239(N)5.6(L\))-235.2(an)4.2(d)-239.3(r)3.1(ollin)4.2(g)-239.2(tob)4.6(a)3.6(cco)-238.6(\()2.8(Amb)4.6(e)-1.8(r)]TJ
0 -1.1847 TD
-.0203 Tc
[(Leaf,)-242(J)1.7(TI\))-246.3(w)4.9(ere)-240.6(u)-2.1(sed)-240.1(a)-2.3(s)-240.9(s)2.3(ub)3.8(stit)]TJ
11.2827 0 TD
-.0225 Tc
[(utes)-5.1(.)-244.2(T)-3.4(wo)-246.7(king-)-4.8(s).1(iz)-4.8(ed)-242.3(r)-5.1(o)1.6(ll)-5.3(ing)]TJ
-11.2827 -1.1795 TD
-.0199 Tc
[(papers)-297.4(\(1)3.9(08)]TJ
/F5 1 Tf
4.6559 0 TD
0 Tc
()Tj
/F7 1 Tf
.6984 0 TD
-.0217 Tc
[(44)-168.7(mm;)-295.2(Riz)-4(l).7(a)-298.6(B)2.6(lue\))-299.5(wer)-4.3(e)-298.9(placed)-298.4(i)-4.8(n)-298.1(front)-299.1(o)-2.8(f)]TJ
-5.3542 -1.1847 TD
-.0212 Tc
[(t)-3.7(h)2.8(e)-427.7(p)2.2(arti)-4.3(cipant.)-429.2(A)3.6(t)-427.9(b)2.9(ase)-3.5(l)1.2(ine,)]TJ
11.381 0 TD
-.0206 Tc
[(participants)-422.2(were)-427.1(asked)-426.6(t)2(o)]TJ
-11.381 -1.1795 TD
-.0217 Tc
[(a)-3.7(d)1.7(d)-215.6(t).9(he)-211()41.1()-.3(amount)-211.2(of)-211.8(c)-4(a)1.4(nnabis)-211.2(a)-3.7(n)2(d)-210.4(t)-4.2(obacc)-4(o)-209.7(they)-210.3(would)-210.4(t)-4.2(yp-)]TJ
0 -1.1847 TD
-.0213 Tc
[(i)-4.4(c)1.5(al)-4.1(ly)-318.6(put)-324.6(i).7(n)-323.5(a)-318.9(joint,)-320.6(if)-325.2(the)-319.2(c)-3.6(annabis)-324.6(a)1.8(nd)-318.7(tobacco)-318(w)-1.3(er)-3.9(e)-319.2(o)-2.4(f)]TJ
0 -1.1795 TD
-.0217 Tc
[(average)-376.5(str)-4.3(ength)-375.3(a)-3.7(nd)-376(quality)-381.1(a)1.4(nd)-381.1(they)-375.9(could)-376(s)-4.3(moke)-376.5(t)-4.2(h)2.3(e)]TJ
T*
0 Tc
[(whole)-388.5(joint)-387(by)-387(themselves.)47()-387.3(One)-388.8(hour)-387.1(after)-388.6(drug)-388.3(ad-)]TJ
0 -1.1847 TD
[(ministration)-297.5(on)-293.7(each)-300.3(drug)-295.2(occasion,)-295.2(participants)-300.2(mea-)]TJ
0 -1.1795 TD
[(sured)-356.1(out)-354.1(cannabis)-358.1(and)-354(tobacco)-353.7(in)-352.6(the)-354.7(same)-355.9(manner.)]TJ
0 -1.1847 TD
[(They)-407.2(were)-403.2(asked)-407.2(to)-408.5(estimate)-405.4(how)-402.7(much)-405.9(the)-406.4(amount)]TJ
0 -1.1795 TD
[(of)-455.7(cannabis)-451.2(and)-452.3(tobacco)-446.8(they)-450.2(want)-453.7(to)-449.9(smoke)-450.5()47.3(right)]TJ
0 -1.1847 TD
[(now.)43.3()-382.1(They)-386.5(were)-382.5(then)-382.7(asked)-386.5(to)-382.7(estimate)-384.7(by)-381.9(sight)-387.1(\(in)]TJ
0 -1.1795 TD
[(g\))-538.9(the)-535.8(amount)-535.1(of)-538.5(cannabis/tobacc)5.2(o)-539.8(i)0(n)-533.7(each)-538.3(rolling)]TJ
0 -1.1847 TD
[(paper.)-447.9(The)-446.2(weight)-439.2(of)-445.4(the)-447.8(cannabis)-440.8(and)-447.1(tobacco)-441.6(was)]TJ
0 -1.1795 TD
[(recorded)-493.3(to)-486.1(the)-489.2(closest)-486.8(0.01)-166(g.)-488(Weighing)-489.7(took)-490.4(place)]TJ
T*
-.0001 Tc
[(under)-551.6(experimenter-blinded)-545.3(conditions)-550.3(and)-545.5(partici-)]TJ
0 -1.1847 TD
0 Tc
[(pants)-303.6(were)-299.8(not)-296.9(given)-298.4(any)-302.2(feedback)-296.6(on)-298.9(their)-299.8(accuracy.)]TJ
/F8 1 Tf
10.4607 0 0 10.4607 59.7543 192.7559 Tm
/Cs8 cs 1 scn
[(Drug)-302.8(administration)-300.3(and)-298.4(procedure)]TJ
/F7 1 Tf
10.959 0 0 10.959 59.7543 179.8298 Tm
0 0 0 rg
-.0221 Tc
[(The)-201(e)-4.4(ffe)-4.4(cts)-201.3(o)-3.2(f)-196.7(\()-5(a\))-201.6(ac)-4.4(tive)-201(c)-4.4(a)1(nnabis)-201.3(and)-200.5(a)1(c)-4.4(t).5(ive)-195.8(t)-4.6(obacc)-4.4(o)-199.8(\(CAN)]TJ
/F5 1 Tf
.1707 -1.1847 TD
0 Tc
(+)Tj
/F7 1 Tf
.8587 0 TD
-.0195 Tc
[(TOB)4.8(\))-2.4(,)-375.7(\()2.8(b\))-374.9(active)-374.3(ca)3.6(nn)4.2(ab)4.6(is)]TJ
/F5 1 Tf
10.4757 0 TD
0 Tc
(+)Tj
/F7 1 Tf
.8639 0 TD
-.0224 Tc
[(pl)-5.2(ace)-4.7(b)1.7(o)-381.1(t).2(obac)-4.7(co)-381.1(\(CAN\),)]TJ
-12.3691 -1.1795 TD
-.0213 Tc
[(\()-4.2(c)1.5(\))-211.1(p)-3.1(lacebo)-209.3(c)-3.6(annabis)]TJ
/F5 1 Tf
8.0184 0 TD
0 Tc
(+)Tj
/F7 1 Tf
.8639 0 TD
-.0211 Tc
[(active)-210.4(tobacco)-214.3(\(TOB\),)-217(and)-209.8(\()-4(d\))-210.9(pla-)]TJ
-8.8823 -1.1847 TD
-.0195 Tc
[(ce)3.3(bo)-398.9(c)3.3(a)-1.5(n)4.2(n)-1(a)3.6(b)-.6(is)]TJ
/F5 1 Tf
5.8146 0 TD
0 Tc
(+)Tj
/F7 1 Tf
.8639 0 TD
-.0217 Tc
[(placebo)-401.1(t)-4.2(obacc)-4(o)-401.1(\(PLACEBO\))-402.9(w)-1.7(ere)-407.5(i).3(n-)]TJ
-6.6786 -1.1795 TD
-.0212 Tc
[(vestigated)-303(\(doses)-298.7(dened)-297.9(in)-302.7(Table)-303.6(1)2.6(;)-299.8(F)-3(ig.)-299.8(1)2.6(\).)]TJ
1.0036 -1.1847 TD
-.0161 Tc
[(On)-478.7(each)-483.5(dr)-3.9(ug)-484.1(sess)-3.9(ion,)-481(par)-3.9(t)1.4(i)-4.4(c)1.6(i)-4.4(p)2.1(ant)-3.8(s)-479.8(smoked)-479(a)-484.4(j)1.1(oint)]TJ
-1.0036 -1.1795 TD
-.0137 Tc
[(\(F)4.5(ig)4.6(.)-349.2(1)4.9(\).)-344.1(T)5.4(h)0(e)-342.6(i)-2(nh)5.2(alation)-347(p)4.5(ro)5.2(cedure)-347.8(w)6.3(as)-342.9(x)4.2(ed)-342.1(and)-342.1(t)3.8(imed)]TJ
T*
-.0141 Tc
[(by)-321.7(an)-321.5(experimenter)-327.8(to)-326.3(ensure)-322.3(consistency)-321.7(b)-.4(etween)-326.7(par-)]TJ
0 -1.1847 TD
-.0133 Tc
[(ticipant)4.2(s)-301.1(a)-.5(nd)-300.3(s)4.1(e)-.8(ssions.)-297.1(Participa)4.7(n)0(ts)-301.1(wer)4.1(e)-300.8(ask)4.9(e)-.8(d)-300.3(t)-1(o)-299.6(i)3.6(nhale)]TJ
0 -1.1795 TD
-.014 Tc
[(for)-250.1(4)-166.1(sec,)-251.2(hold)-254.5(t)3.5(heir)-250.1(b)4.9(r)-1.8(eath)-253.8(for)-250.1(8)-166.1(sec,)-251.2(and)-249.3(t)-1.7(hen)-254.1(e)3.7(xhale)-249.8(a)4(nd)]TJ
22.912 22.4567 TD
-.0132 Tc
[(break)-393.3(f)-1.5(or)-394.1(30)-165.3(se)4.5(c.)-395.3(This)-394.1(seq)5.3(u)-.2(ence)-393.9(was)-394.1(r)-1(epe)4.5(a)-.4(ted)-393.3(u)-.2(ntil)-394.3(the)]TJ
0 -1.1847 TD
-.0128 Tc
[(j)4.4(o).9(int)-248.8(w)2(as)-248.9(smoked)-253.3(u)5.4(p)-253.3(to)-247.4(a)-253.5(d).2(e)4.9(s)-.6(igna)5.2(ted)-248.1(l)-.8(ine)-248.6(\()-.9(Fi)4.1(g.)-250(1\).)-250(P).8(art)4.7(i)-1.1(c-)]TJ
0 -1.1795 TD
-.0136 Tc
[(ipants)-467(completed)-466.2(t)-1.3(he)-466.7()44()2.6(Roll)-467.1(a)-466.4(J)-2(oint)44()-468.1(paradigm)-469(on)-465.8(the)]TJ
0 -1.1847 TD
-.0129 Tc
[(ba)5.1(seline)-352.2(se)4.8(ssio)6(n)-351.3(and)-351.6(a)-.1(t)]TJ
/F12 1 Tf
9.3583 0 TD
0 Tc
(*)Tj
/F7 1 Tf
.9829 0 TD
-.0133 Tc
[(1)-170.6(h)-346.2(after)-352.9(d)-.3(ru)4.9(g)-352(a)-.5(dministratio)5.6(n)]TJ
-10.3412 -1.1795 TD
[(on)-294.8(each)-294.5(drug)-295.1(session.)-297.1(Visual)-296.1(A)-13.3(n)14.5(alogue)-295.7(Scale)-300.9(\()3.8(VAS\))-301.4(rat-)]TJ
T*
[(ings)-378.7(o)5.6(f)-379.3(stone)4.4(d)-379.9(\(from)-370.4(n)0(ot)-378.6(a)4.7(t)-378.6(a)4.7(l)-1.3(l)-373.7([)-1.4(0])-373.9(to)-372(extre)4.4(m)-3.1(e)4.4(l)-1.3(y)-372.7([)-1.4(10]\))]TJ
0 -1.1847 TD
-.0148 Tc
[(were)-431.7(taken)-430.8(a)-2(t)]TJ
/F13 1 Tf
5.7939 0 TD
0 Tc
()Tj
/F7 1 Tf
.6363 0 TD
-.0134 Tc
(10,)Tj
/F5 1 Tf
1.5933 0 TD
0 Tc
(+)Tj
/F7 1 Tf
.569 0 TD
-.0134 Tc
[(10)5.2(,)]TJ
/F5 1 Tf
1.5933 0 TD
0 Tc
(+)Tj
/F7 1 Tf
.569 0 TD
-.0186 Tc
[(30)-5.2(,)]TJ
/F5 1 Tf
1.5933 0 TD
0 Tc
(+)Tj
/F7 1 Tf
.569 0 TD
-.0186 Tc
[(40)-5.2(,)-436.9(a)-5.8(n)-5.3(d)]TJ
/F5 1 Tf
3.4764 0 TD
0 Tc
(+)Tj
/F7 1 Tf
.569 0 TD
-.0135 Tc
[(70)-165.6(min)-429.5(a)-.7(fter)]TJ
-16.9628 -1.1795 TD
-.0132 Tc
[(dr)4.2(ug)-434.6(administ)4.3(ration.)-431.5(A)-13.2(l)13.3(l)-435.7(p)5(a)-.4(rticipan)5.3(ts)-435.5(p)5(r)-1(ovide)4.5(d)-434.7(written)]TJ
0 -1.1847 TD
[(informed)-481.3(consent)-482(o).5(n)-486.1(e)4.5(ach)-480.6(o).5(ccasion.)-483.2(E).4(th)5.7(ical)-482.3(app)5(r)-1(oval)]TJ
0 -1.1795 TD
[(was)-296(g)-.2(iven)-294.8(by)-300.2(the)-300.9(U)1.8(CL)-299.7(Et)4.2(hics)-296(Committee)4.4(.)]TJ
/F8 1 Tf
10.4607 0 0 10.4607 310.8472 166.9039 Tm
/Cs8 cs 1 scn
0 Tc
[(Statistical)-301.5(analysis)]TJ
/F7 1 Tf
10.959 0 0 10.959 310.8472 153.9212 Tm
0 0 0 rg
-.0233 Tc
[(Bonferro)5.9(ni)-203(co)5.9(rrected)-201.7(pa)5(ired)-196.5(sample)]TJ
/F10 1 Tf
13.4451 0 TD
0 Tc
(t)Tj
/F7 1 Tf
.2794 0 TD
-.0246 Tc
[(-)3.5(t)-1.9(ests)-203.8(were)-203.5(condu)4(c)-1.8(ted)]TJ
-13.7244 -1.1795 TD
-.0232 Tc
[(be)4.8(tween)-263.4(bas)4.5(e)-.4(lin)5.7(e)-264.2()44.8()-1.8(ac)4.8(tual)49.9()-265.6(and)-263.7()44.8(estima)5.1(ted)44.8()-260.4(d).2(ose)-264.2(t)-.6(o)-263(i)4(nvest)4.6(i)-1.2(-)]TJ
T*
-.024 Tc
[(gate)-254.6(participants)-256.1(a)-.9(ccuracy)-248.9(i)-2(n)-253.8(g)-.5(uessing)-248.9(d)-.6(ose.)-250.9(Linear)-254.9(mixed)]TJ
0 -1.1847 TD
0 Tc
[(models,)-256.7(with)-257.9(a)-256.2(random)-261(intercept)-255(for)-262.5()47.3(participant,)46.7()-263.1(and)]TJ
0 -1.1795 TD
-.0213 Tc
[(two)-354.2(w)3.9(it)-3.8(hin)-354.6(s)-3.9(ubjects)-355.7(f).7(actor)-3.9(s)-350.5(of)-351.1(cannabis)-355.7(\(placebo;)-356.8(active\))]TJ
0 -1.1847 TD
0 Tc
[(and)-473(tobacco)-472.7(\(placebo;)-471.3(active\))-471.9(were)-475.6(implemented)-472.1(on)]TJ
0 -1.1795 TD
.0147 Tc
[(both)-494.1(actual)-495.8(and)-494.8(e)1.3(s)-4.1(t)1.1(imated)-489.6(dos)-4.1(e)1.3(.)-491.5(T)-2.4(he)-495.3(unstructured)]TJ
0 -1.1847 TD
.0238 Tc
[(var)-5.4(i)-.7(anc)-5.1(e).1(/covar)-5.4(ianc)-5.1(e)-543.1(s)-.2(tr)-5.4(uct)-5.3(u).6(re)-548.3(was)-548.5(s)-.2(el)-5.6(ected.)]TJ
8.2191 0 0 7.3052 517.8896 68.1449 Tm
.0314 Tc
(15)Tj
10.959 0 0 10.959 532.2896 63.2692 Tm
.0223 Tc
[(Th)-5.4(e)]TJ
ET
/EmbeddedDocument /MC7 BDC
/Document /MC8 BDC
q
1 i
572.031 35.263 10.035 -19.162 re
W n
.88034 .35499 .53448 .13513 k
q 1 0 0 1 572.031 16.059 cm 0 0 m
.966 3.153 1.461 4.22 v
1.739 4.818 2.425 6.378 3.087 7.332 c
3.497 7.924 4.368 8.916 4.541 9.196 c
4.633 9.338 4.701 9.556 y
4.901 9.641 5.09 9.748 v
5.279 9.856 5.638 10.053 5.702 10.24 c
5.807 10.549 5.997 10.624 y
6.187 10.665 6.271 10.678 v
6.44 10.7 6.566 10.773 6.735 10.859 c
6.904 10.946 7.12 11.062 7.516 11.253 c
7.799 11.391 10.08 12.245 y
10.048 12.162 9.858 12.011 v
9.667 11.863 9.25 11.707 9.083 11.621 c
8.914 11.536 7.475 10.817 7.199 10.646 c
6.926 10.474 6.091 9.925 5.47 9.366 c
5.02 8.96 4.51 8.356 4.184 7.914 c
3.263 6.665 2.748 5.394 y
3.551 5.415 3.613 5.415 v
3.676 5.415 3.845 4.924 y
3.212 5.01 2.938 4.861 v
2.663 4.712 2.592 4.659 2.358 4.273 c
2.129 3.895 1.618 2.108 1.314 1.137 c
1.22 .833 1.125 .399 .936 .306 c
.813 .243 0 0 y
f
Q
Q
.8706 .35352 .53033 .13062 K
0 J 0 j .405 w 4 M []0 d
/GS2 gs
1 i
q 1 0 0 1 577.63 22.436 cm 0 0 m
.403 .006 .637 -.007 v
.776 -.013 .996 -.05 1.152 -.097 c
1.288 -.142 1.451 -.222 1.542 -.287 c
1.659 -.373 1.711 -.47 1.783 -.567 c
1.832 -.637 1.991 -1.045 2.063 -1.095 c
2.136 -1.142 2.146 -1.179 2.081 -1.222 c
2.03 -1.257 2.004 -1.324 1.984 -1.373 c
1.965 -1.424 1.89 -1.613 1.84 -1.767 c
1.802 -1.888 1.742 -1.958 1.704 -2.004 c
1.646 -2.071 1.529 -2.169 1.405 -2.236 c
1.312 -2.284 1.146 -2.357 .995 -2.388 c
.716 -2.45 .292 -2.479 .174 -2.469 c
S
Q
.88034 .35499 .53448 .13513 k
q 1 0 0 1 576.761 19.774 cm 0 0 m
-.054 0 -.095 .021 -.095 .045 c
-.095 .068 -.054 .088 0 .088 c
.05 .088 .094 .068 .094 .045 c
.094 .021 .05 0 0 0 c
-.35 .372 m
-.35 .416 -.271 .451 -.175 .451 c
-.08 .451 0 .416 0 .372 c
0 .328 -.08 .292 -.175 .292 c
-.271 .292 -.35 .328 -.35 .372 c
-.46 .766 m
-.46 .826 -.36 .874 -.238 .874 c
-.116 .874 -.018 .826 -.018 .766 c
-.018 .705 -.116 .656 -.238 .656 c
-.36 .656 -.46 .705 -.46 .766 c
-.586 1.181 m
-.586 1.262 -.477 1.325 -.34 1.325 c
-.206 1.325 -.095 1.262 -.095 1.181 c
-.095 1.101 -.206 1.036 -.34 1.036 c
-.477 1.036 -.586 1.101 -.586 1.181 c
-.19 1.641 m
-.19 1.587 -.269 1.545 -.364 1.545 c
-.462 1.545 -.539 1.587 -.539 1.641 c
-.539 1.691 -.462 1.732 -.364 1.732 c
-.269 1.732 -.19 1.691 -.19 1.641 c
-.373 2.112 m
-.265 2.112 -.175 2.066 -.175 2.012 c
-.175 1.954 -.265 1.908 -.373 1.908 c
-.481 1.908 -.569 1.954 -.569 2.012 c
-.569 2.066 -.481 2.112 -.373 2.112 c
-.303 2.491 m
-.215 2.491 -.143 2.459 -.143 2.418 c
-.143 2.379 -.215 2.347 -.303 2.347 c
-.39 2.347 -.46 2.379 -.46 2.418 c
-.46 2.459 -.39 2.491 -.303 2.491 c
-.175 2.753 m
-.131 2.753 -.095 2.735 -.095 2.708 c
-.095 2.688 -.131 2.666 -.175 2.666 c
-.22 2.666 -.255 2.688 -.255 2.708 c
-.255 2.735 -.22 2.753 -.175 2.753 c
1.513 .335 m
1.371 .352 1.288 .352 1.196 .352 c
1.101 .352 1.021 .346 .69 .352 c
.478 .355 .535 .471 .729 .496 c
.809 .507 .849 .51 .896 .518 c
.944 .525 .991 .532 1.212 .576 c
1.433 .62 1.308 .699 1.138 .712 c
1.009 .72 .952 .722 .903 .722 c
.824 .722 .78 .724 .569 .738 c
.3 .763 .425 .882 .548 .904 c
.611 .914 .637 .918 .675 .926 c
.715 .935 .738 .941 .984 .977 c
1.229 1.013 1.118 1.099 .976 1.109 c
.833 1.126 .809 1.13 .741 1.134 c
.68 1.137 .642 1.136 .471 1.158 c
.312 1.181 .375 1.266 .461 1.286 c
.547 1.308 .606 1.32 .661 1.321 c
.694 1.324 .723 1.33 .889 1.355 c
1.113 1.388 1.118 1.479 .868 1.512 c
.743 1.529 .723 1.53 .698 1.533 c
.661 1.54 .64 1.545 .44 1.566 c
.251 1.588 .304 1.698 .471 1.72 c
.589 1.734 .658 1.743 .69 1.749 c
.723 1.752 .77 1.752 .929 1.77 c
1.143 1.795 1.156 1.899 .936 1.918 c
.809 1.933 .797 1.93 .745 1.934 c
.715 1.937 .705 1.933 .485 1.953 c
.286 1.97 .358 2.07 .494 2.092 c
.62 2.112 .71 2.128 .802 2.142 c
.833 2.146 .858 2.14 1.131 2.2 c
1.284 2.233 1.25 2.308 1.068 2.315 c
1.002 2.32 .884 2.331 .793 2.339 c
.715 2.347 .666 2.347 .517 2.359 c
.366 2.374 .494 2.484 .548 2.499 c
.604 2.514 .84 2.536 .965 2.543 c
1.094 2.55 1.284 2.556 1.394 2.587 c
1.492 2.614 1.433 2.673 1.338 2.695 c
1.29 2.705 1.261 2.713 1.182 2.728 c
1.101 2.742 1.046 2.745 .965 2.761 c
.872 2.78 .889 2.769 .849 2.789 c
.809 2.815 .759 2.899 y
.729 2.985 .683 2.985 v
.636 2.985 .563 2.987 .421 2.987 c
.28 2.987 .326 2.995 .265 2.995 c
.2 2.995 .112 3.01 .026 3.016 c
-.061 3.024 -.171 3.03 -.227 3.024 c
-.281 3.016 -.358 2.992 -.417 2.959 c
-.504 2.906 -.622 2.778 -.692 2.695 c
-.764 2.614 -.875 2.397 -.915 2.323 c
-.954 2.251 -1.08 1.887 -1.129 1.808 c
-1.175 1.727 -1.302 1.675 y
-1.511 1.573 -1.387 1.54 v
-.964 1.423 -1.325 1.269 y
-1.31 1.172 l
-1.27 1.172 -1.262 1.153 v
-1.254 1.13 -1.129 1.158 -1.024 .874 c
-.977 .742 -.933 .651 -.85 .468 c
-.811 .38 -.677 .054 -.446 -.092 c
-.195 -.252 .012 -.207 .121 -.194 c
.251 -.181 .471 -.128 .581 -.125 c
.723 -.114 .763 -.114 .88 -.107 c
.999 -.099 1.361 -.092 y
.873 0 .778 0 v
.683 0 1.007 .094 1.142 .116 c
1.261 .139 1.378 .168 y
1.418 .184 1.553 .212 v
1.688 .242 1.655 .321 1.513 .335 c
f
Q
.88034 .35499 .53448 .13513 K
q 1 0 0 1 576.744 25.907 cm 0 0 m
-.066 -.119 -.079 -.096 v
-.122 .003 -.244 .254 -.395 .343 c
-.586 .454 -1.661 .89 -1.821 .965 c
-1.948 1.026 -2.464 1.133 -2.75 1.614 c
-3.04 2.104 -3.099 2.207 -3.229 2.355 c
-3.403 2.553 -3.277 2.712 -3.07 2.738 c
-2.962 2.752 -2.821 2.753 -2.718 2.753 c
-2.656 2.754 -2.654 2.877 -2.658 3.009 c
-2.668 3.222 -2.723 3.28 -2.881 3.41 c
-3.04 3.536 -3.323 3.744 -3.387 3.921 c
-3.451 4.096 -3.373 4.398 -3.53 4.526 c
-3.687 4.656 -4.023 4.897 -4.1 5.244 c
-4.164 5.532 -4.025 5.669 -3.927 5.723 c
-3.772 5.808 -3.609 5.804 -3.482 5.676 c
-3.354 5.549 -3.341 5.389 -3.277 5.311 c
-3.214 5.229 -3.051 5.181 -2.976 5.149 c
-2.875 5.106 -2.769 5.065 -2.643 5.032 c
-2.598 5.021 -2.38 4.925 -2.339 5.021 c
-2.302 5.102 -2.351 5.196 -2.389 5.311 c
-2.47 5.532 -3.008 5.771 -3.07 5.837 c
-3.134 5.899 -3.335 6.063 -3.403 6.377 c
-3.467 6.671 -3.468 6.71 -3.53 6.857 c
-3.637 7.108 -3.585 7.299 -3.552 7.427 c
-3.51 7.591 -3.627 7.705 -3.547 7.8 c
-3.446 7.916 -3.299 7.981 -3.198 7.911 c
-3.122 7.856 -3.023 7.773 -2.96 7.726 c
-2.895 7.676 -2.854 7.64 -2.707 7.554 c
-2.596 7.489 -2.439 7.54 -2.327 7.512 c
-2.242 7.489 -2.082 7.349 -2.074 7.364 c
-2.025 7.443 -2.058 7.561 -2.074 7.688 c
-2.09 7.814 -2.216 8.07 -2.247 8.151 c
-2.28 8.23 -2.31 8.359 -2.231 8.469 c
-2.153 8.582 -1.963 8.82 -1.868 8.932 c
-1.773 9.045 -1.661 9.284 -1.504 9.061 c
-1.344 8.836 -1.282 8.694 -1.202 8.646 c
-1.124 8.597 -1.039 8.597 -.917 8.63 c
-.799 8.661 -.646 8.694 -.537 8.726 c
-.426 8.755 -.346 8.836 -.252 8.902 c
-.157 8.965 -.093 8.98 -.03 8.948 c
.033 8.917 .059 8.874 .097 8.789 c
.122 8.729 .122 8.63 .144 8.55 c
.184 8.396 .229 8.322 .207 8.263 c
.159 8.129 .065 8.024 .033 7.927 c
0 7.831 .059 7.567 .018 7.496 c
-.046 7.383 -.109 7.352 -.141 7.239 c
-.173 7.13 -.141 7.001 -.093 6.905 c
-.046 6.811 -.046 6.714 -.03 6.634 c
-.014 6.554 .082 6.603 .144 6.681 c
.207 6.762 .207 6.841 .271 6.953 c
.334 7.064 .491 7.064 .635 7.082 c
.764 7.095 .925 7.258 1.063 7.273 c
1.141 7.281 1.285 7.242 1.348 7.13 c
1.442 6.957 1.458 6.793 1.378 6.664 c
1.3 6.539 1.18 6.429 1.143 6.282 c
1.094 6.097 1.074 5.872 .968 5.723 c
.866 5.581 .727 5.501 .635 5.358 c
.533 5.191 .508 4.877 .555 4.718 c
.604 4.558 .661 4.602 .698 4.687 c
.746 4.795 .787 4.904 .888 4.957 c
1.086 5.061 1.327 5.17 1.475 5.181 c
1.554 5.186 1.712 5.102 1.775 4.973 c
1.839 4.846 1.816 4.657 1.79 4.526 c
1.737 4.276 1.671 4.01 1.602 3.921 c
1.505 3.796 1.391 3.694 1.237 3.584 c
1.08 3.473 .715 3.298 .57 3.201 c
.407 3.091 .323 2.923 .292 2.797 c
.261 2.673 .302 2.578 .382 2.578 c
.46 2.578 .555 2.721 .604 2.785 c
.65 2.851 .705 2.992 .798 3.009 c
.904 3.03 1.031 2.963 1.143 2.963 c
1.253 2.963 1.316 3.009 1.442 3.042 c
1.569 3.073 1.649 2.999 1.632 2.871 c
1.616 2.744 1.616 2.674 1.553 2.593 c
1.49 2.513 1.316 2.419 1.3 2.307 c
1.284 2.194 1.318 2.064 1.3 1.972 c
1.273 1.838 1.143 1.747 1.016 1.635 c
.888 1.525 .46 1.179 .367 .981 c
.3 .844 .3 .566 .318 .454 c
.345 .294 .398 .262 y
.431 .262 .132 .139 .121 .127 c
.047 .055 0 0 y
h
S 1 0 0 1 1.403 6.747 cm 0 0 m
.079 .046 .119 .094 .222 .199 c
.324 .301 .436 .422 .505 .501 c
.559 .56 .696 .684 .768 .806 c
.828 .905 .87 .941 .95 .949 c
.997 .953 1.107 .949 1.164 .972 c
1.22 .996 1.367 1.077 1.417 1.115 c
1.456 1.149 1.679 1.195 1.728 1.021 c
1.777 .829 1.784 .588 1.757 .526 c
1.693 .374 1.6 .262 1.552 .11 c
1.522 .022 1.527 -.153 1.583 -.312 c
1.633 -.459 1.703 -.393 1.798 -.337 c
1.893 -.281 1.964 -.25 2.041 -.258 c
2.121 -.266 2.462 -.312 2.51 -.322 c
2.556 -.328 2.636 -.37 2.612 -.449 c
2.589 -.527 2.431 -.817 2.312 -.92 c
2.192 -1.024 2.105 -1.111 2.083 -1.175 c
2.058 -1.238 1.995 -1.406 1.985 -1.487 c
1.979 -1.566 1.853 -1.718 1.78 -1.765 c
1.709 -1.812 1.393 -2.014 1.346 -2.054 c
1.299 -2.091 1.11 -2.161 1.274 -2.349 c
1.393 -2.484 1.4 -2.421 1.456 -2.413 c
1.513 -2.403 1.545 -2.391 1.646 -2.324 c
1.757 -2.254 1.86 -2.229 1.972 -2.277 c
2.083 -2.324 2.163 -2.357 2.192 -2.403 c
2.257 -2.499 2.202 -2.581 2.176 -2.62 c
2.146 -2.671 1.868 -2.946 1.813 -3.003 c
1.757 -3.059 1.527 -3.259 1.456 -3.315 c
1.387 -3.371 1.22 -3.529 1.171 -3.633 c
1.124 -3.738 1.068 -3.953 1.021 -4.034 c
.974 -4.113 .775 -4.295 .607 -4.407 c
.442 -4.52 .135 -4.736 .071 -4.847 c
.027 -4.922 -.008 -5.127 -.025 -5.288 c
-.04 -5.446 0 -5.589 y
-.119 -5.614 -.205 -5.638 v
-.294 -5.662 -.364 -5.741 -.364 -5.798 c
-.364 -5.853 -.491 -5.988 y
-.477 -5.853 -.554 -5.766 v
-.634 -5.676 -.713 -5.567 -.761 -5.542 c
S
Q
q 1 0 0 1 576.579 25.908 cm 0 0 m
.054 .175 l
-.08 .388 -.135 .459 v
-.19 .531 -.809 1.001 -.901 1.074 c
-.995 1.145 -1.305 1.351 -1.409 1.39 c
-2.032 1.677 -2.075 1.693 v
-2.12 1.712 -2.419 1.883 -2.468 1.909 c
-2.517 1.936 -2.639 2.005 -2.678 2.031 c
-2.715 2.059 -2.748 2.122 -2.748 2.148 c
-2.748 2.176 -2.731 2.227 -2.71 2.221 c
-2.687 2.216 -2.639 2.221 -2.616 2.197 c
-2.596 2.176 -2.507 2.138 -2.456 2.109 c
-2.406 2.081 -2.037 1.901 -1.993 1.879 c
-1.949 1.854 -1.623 1.689 -1.574 1.671 c
-1.523 1.654 -1.294 1.545 -1.255 1.522 c
-1.217 1.501 -1.133 1.445 -1.077 1.418 c
-1.021 1.39 -.901 1.316 -.873 1.297 c
-.848 1.272 -.72 1.179 -.692 1.145 c
-.664 1.114 -.477 .996 -.454 .978 c
-.433 .964 -.301 .836 -.278 .825 c
-.257 .813 -.18 .759 -.162 .754 c
-.146 .747 -.112 .729 -.092 .74 c
-.067 .754 -.057 .818 -.063 .852 c
-.067 .886 -.162 1.346 -.18 1.424 c
-.194 1.501 -.262 1.833 -.278 1.888 c
-.296 1.942 -.41 2.109 -.516 2.187 c
-.619 2.266 -1.105 2.664 -1.166 2.702 c
-1.227 2.739 -1.508 2.946 -1.585 2.984 c
-1.663 3.024 -1.91 3.179 -1.977 3.223 c
-2.044 3.268 -2.374 3.495 -2.43 3.545 c
-2.484 3.594 -2.864 4.004 -2.936 4.082 c
-3.009 4.16 -3.274 4.55 -3.332 4.646 c
-3.393 4.747 -3.538 4.891 -3.603 4.974 c
-3.671 5.057 -3.734 5.167 -3.741 5.207 c
-3.746 5.247 -3.696 5.334 -3.603 5.258 c
-3.511 5.179 -3.454 5.124 -3.399 5.086 c
-3.344 5.046 -3.3 5.003 -3.262 4.945 c
-3.224 4.891 -3.151 4.796 -3.123 4.753 c
-3.096 4.708 -2.97 4.515 -2.926 4.454 c
-2.883 4.392 -2.706 4.136 -2.605 4.022 c
-2.507 3.903 -2.253 3.635 -1.784 3.351 c
-1.317 3.068 -.757 2.691 -.697 2.658 c
-.637 2.623 -.592 2.576 -.554 2.576 c
-.516 2.576 -.498 2.598 -.487 2.623 c
-.477 2.652 -.521 2.758 -.544 2.829 c
-.565 2.901 -.603 3.279 -.626 3.383 c
-.648 3.488 -.823 4.42 -.848 4.499 c
-.867 4.575 -.852 4.715 -1.001 4.806 c
-1.148 4.902 -1.547 5.194 -1.618 5.252 c
-1.69 5.306 -2.264 5.859 -2.324 5.927 c
-2.386 5.992 -2.673 6.332 -2.721 6.38 c
-2.771 6.432 -2.941 6.636 -2.981 6.741 c
-3.018 6.846 -3.047 6.912 -3.079 6.99 c
-3.113 7.068 -3.185 7.234 -3.206 7.283 c
-3.228 7.335 -3.25 7.416 -3.245 7.434 c
-3.239 7.45 -3.218 7.473 -3.175 7.45 c
-3.129 7.428 -3.024 7.29 -3.004 7.251 c
-2.981 7.213 -2.876 7.046 -2.858 7.002 c
-2.843 6.958 -2.803 6.868 -2.776 6.823 c
-2.748 6.781 -2.534 6.476 -2.462 6.402 c
-2.391 6.332 -2.147 6.07 -2.087 6.016 c
-2.027 5.961 -1.518 5.449 -1.435 5.379 c
-1.353 5.306 -1.188 5.2 -1.144 5.184 c
-1.101 5.167 -1.057 5.167 -1.035 5.179 c
-1.011 5.189 -.984 5.222 -.99 5.322 c
-.995 5.423 -1.105 6.353 -1.128 6.486 c
-1.148 6.621 -1.271 7.022 -1.3 7.135 c
-1.325 7.245 -1.364 7.571 -1.392 7.794 c
-1.419 8.016 -1.568 8.645 -1.613 8.737 c
-1.657 8.824 -1.686 8.912 -1.705 8.963 c
-1.728 9.012 -1.767 9.105 -1.739 9.152 c
-1.714 9.195 -1.646 9.339 -1.613 9.334 c
-1.579 9.329 -1.534 9.31 -1.514 9.272 c
-1.491 9.233 -1.446 8.984 -1.435 8.935 c
-1.426 8.884 -1.31 8.337 -1.305 8.293 c
-1.3 8.247 -1.242 8.098 -1.232 8.038 c
-1.223 7.976 -1.184 7.728 -1.178 7.622 c
-1.172 7.517 -1.139 7.406 -1.111 7.385 c
-1.083 7.361 -1.05 7.367 -1.018 7.379 c
-.984 7.389 -.945 7.522 -.911 7.583 c
-.88 7.643 -.71 7.905 -.671 7.947 c
-.631 7.991 -.537 8.198 -.516 8.237 c
-.493 8.275 -.388 8.48 -.356 8.535 c
-.321 8.592 -.229 8.714 -.2 8.755 c
-.174 8.79 -.129 8.867 -.102 8.863 c
-.074 8.857 -.009 8.824 y
.048 8.784 .014 8.709 v
-.018 8.63 -.14 8.486 -.174 8.432 c
-.207 8.377 -.345 8.128 -.388 8.026 c
-.433 7.928 -.615 7.711 -.644 7.667 c
-.671 7.622 -.775 7.373 -.813 7.283 c
-.852 7.193 -.919 7.018 -.935 6.924 c
-.95 6.83 -.919 6.396 -.906 6.332 c
-.896 6.265 -.79 5.526 -.78 5.395 c
-.769 5.262 -.736 5.057 -.72 4.997 c
-.702 4.935 -.687 4.764 -.676 4.663 c
-.664 4.564 -.659 4.509 -.631 4.481 c
-.603 4.454 -.565 4.447 -.544 4.465 c
-.521 4.481 -.382 4.698 -.349 4.747 c
-.316 4.796 -.169 5.04 -.146 5.067 c
-.123 5.097 .108 5.35 .18 5.407 c
.253 5.461 .394 5.59 .449 5.683 c
.505 5.776 .561 5.882 .621 6.032 c
.681 6.182 .731 6.409 .77 6.47 c
.81 6.529 .896 6.697 .931 6.741 c
.963 6.787 1.14 7.002 1.194 7.033 c
1.25 7.068 1.305 7.117 1.338 7.117 c
1.37 7.117 1.403 7.074 1.397 7.04 c
1.394 7.008 1.338 6.944 1.315 6.92 c
1.296 6.891 1.129 6.691 1.101 6.636 c
1.072 6.581 .913 6.265 .896 6.192 c
.88 6.121 .831 5.91 .798 5.844 c
.764 5.776 .72 5.667 .647 5.566 c
.576 5.467 .466 5.362 .372 5.272 c
.279 5.184 .081 5.029 .004 4.895 c
-.074 4.764 -.339 4.38 -.373 4.277 c
-.406 4.172 -.576 3.938 -.472 3.523 c
-.367 3.107 -.333 3.019 y
-.321 2.901 -.262 2.936 v
-.2 2.968 -.146 3.102 -.097 3.156 c
-.047 3.212 .141 3.434 .19 3.477 c
.24 3.523 .389 3.665 .477 3.738 c
.566 3.811 .852 4.031 .907 4.071 c
.963 4.11 1.167 4.287 1.212 4.337 c
1.255 4.388 1.382 4.582 1.409 4.612 c
1.438 4.646 1.496 4.708 1.531 4.708 c
1.564 4.708 1.619 4.675 1.603 4.612 c
1.586 4.555 1.543 4.475 1.491 4.397 c
1.442 4.321 1.37 4.216 1.338 4.176 c
1.305 4.136 1.194 4.056 1.145 4.009 c
1.095 3.967 .88 3.827 .81 3.761 c
.736 3.695 .652 3.635 .512 3.502 c
.365 3.366 .312 3.323 .229 3.223 c
.147 3.125 0 2.885 -.041 2.792 c
-.08 2.696 -.135 2.498 -.135 2.427 c
-.135 2.353 -.097 2.031 -.063 1.883 c
-.03 1.732 -.03 1.599 .014 1.549 c
.059 1.501 .091 1.506 .118 1.527 c
.147 1.549 .168 1.645 .208 1.693 c
.246 1.743 .284 1.788 .322 1.833 c
.362 1.879 .5 1.993 .543 2.026 c
.587 2.059 .692 2.148 .746 2.187 c
.804 2.227 .958 2.387 1.013 2.42 c
1.067 2.455 1.15 2.514 1.188 2.52 c
1.229 2.524 1.319 2.547 1.343 2.542 c
1.366 2.538 1.426 2.504 1.388 2.458 c
1.349 2.414 1.217 2.298 1.188 2.275 c
1.161 2.254 1.007 2.122 .936 2.059 c
.862 1.999 .72 1.904 .665 1.86 c
.61 1.816 .517 1.727 .472 1.671 c
.429 1.615 .362 1.506 .328 1.424 c
.295 1.339 .246 1.114 .229 .99 c
.212 .867 .24 .724 .253 .687 c
.263 .646 .267 .609 .279 .575 c
.29 .543 .345 .452 .365 .569 c
.389 .687 .417 .874 .477 .946 c
.537 1.02 .715 1.25 .731 1.095 c
.746 .94 .556 .598 .569 .475 c
.587 .354 .551 .192 .482 .092 c
.417 -.007 .196 -.072 .158 -.067 c
.118 -.062 0 0 y
f
Q
q 1 0 0 1 578.21 27.082 cm 0 0 m
.164 .542 .176 .587 v
.188 .631 .131 .741 .121 .775 c
.109 .81 .054 .932 .054 .984 c
.054 1.042 .065 1.107 .109 1.13 c
.153 1.153 .176 1.175 .231 1.239 c
.285 1.308 .341 1.363 .351 1.462 c
.363 1.561 .351 1.596 .386 1.673 c
.418 1.75 .462 1.817 .551 1.872 c
.638 1.928 .693 1.993 .772 2.037 c
.849 2.081 .926 2.172 .98 2.228 c
1.036 2.282 1.148 2.393 1.213 2.427 c
1.279 2.461 1.345 2.482 1.411 2.491 c
1.476 2.505 1.521 2.516 1.599 2.537 c
1.676 2.56 1.753 2.659 1.775 2.692 c
1.797 2.726 1.786 2.825 1.664 2.78 c
1.543 2.735 1.366 2.692 1.313 2.682 c
1.256 2.669 1.114 2.637 1.07 2.592 c
1.025 2.549 .97 2.461 .849 2.383 c
.728 2.304 .65 2.206 .584 2.206 c
.517 2.206 .484 2.206 .508 2.315 c
.529 2.427 .54 2.592 .574 2.726 c
.606 2.857 .65 3.058 .672 3.157 c
.693 3.259 .737 3.445 .804 3.469 c
.87 3.489 .991 3.545 1.091 3.645 c
1.19 3.744 1.323 3.866 1.4 3.954 c
1.476 4.042 1.599 4.276 1.664 4.331 c
1.73 4.388 1.84 4.509 1.952 4.553 c
2.062 4.598 1.996 4.589 2.161 4.62 c
2.326 4.653 2.37 4.644 2.437 4.686 c
2.503 4.731 2.548 4.775 2.514 4.786 c
2.481 4.797 2.481 4.797 2.415 4.831 c
2.349 4.863 2.293 4.907 2.216 4.887 c
2.14 4.863 2.05 4.843 1.974 4.809 c
1.897 4.775 1.709 4.696 1.653 4.62 c
1.599 4.542 1.433 4.366 1.378 4.299 c
1.323 4.233 1.224 4.11 1.179 4.057 c
1.134 3.999 1.08 3.945 1.025 3.912 c
.97 3.878 .837 3.844 .87 3.978 c
.904 4.11 .915 4.255 .949 4.398 c
.98 4.542 1.014 4.809 1.091 4.887 c
1.168 4.965 1.289 5.098 1.345 5.151 c
1.4 5.206 1.476 5.328 1.378 5.317 c
1.279 5.307 1.224 5.417 1.235 5.496 c
1.245 5.574 1.279 5.827 1.313 5.938 c
1.345 6.05 1.423 6.248 1.456 6.315 c
1.488 6.381 1.5 6.436 1.588 6.525 c
1.676 6.615 1.808 6.647 1.719 6.727 c
1.631 6.803 1.313 6.959 1.411 6.925 c
1.51 6.892 1.4 6.77 1.389 6.727 c
1.378 6.682 1.323 6.626 1.289 6.525 c
1.256 6.427 1.19 6.283 1.168 6.183 c
1.148 6.082 1.058 5.807 1.047 5.672 c
1.036 5.539 .991 5.496 .991 5.45 c
.991 5.406 .915 5.328 .86 5.429 c
.804 5.528 .804 5.607 .782 5.695 c
.76 5.783 .772 5.871 .76 5.928 c
.75 5.982 .617 6.082 .617 5.938 c
.617 5.794 .606 5.761 .617 5.695 c
.627 5.628 .627 5.561 .638 5.474 c
.65 5.385 .716 5.131 .75 5.074 c
.782 5.019 .849 4.887 .826 4.775 c
.804 4.664 .75 4.589 .728 4.509 c
.704 4.434 .661 4.276 .508 4.441 c
.351 4.609 -.065 5.273 -.1 5.317 c
-.134 5.363 -.177 5.395 -.221 5.284 c
-.265 5.175 -.299 5.295 -.211 5.141 c
-.123 4.986 -.033 4.852 .021 4.731 c
.076 4.609 .176 4.498 .231 4.419 c
.285 4.344 .351 4.276 .407 4.188 c
.462 4.1 .484 4.089 .473 3.889 c
.462 3.689 .407 3.29 .351 2.914 c
.297 2.537 .231 2.206 .176 2.116 c
.121 2.027 .109 1.982 0 2.072 c
-.111 2.16 -.078 2.26 -.123 2.304 c
-.167 2.351 -.243 2.404 -.32 2.36 c
-.397 2.315 -.541 2.238 -.53 2.172 c
-.519 2.105 -.608 2.126 -.464 2.072 c
-.32 2.016 -.299 2.006 -.265 1.95 c
-.233 1.895 -.221 1.883 -.177 1.829 c
-.134 1.772 -.1 1.807 -.012 1.772 c
.076 1.739 .099 1.783 .131 1.693 c
.164 1.607 .241 1.65 .164 1.484 c
.087 1.318 -.055 1.283 -.111 1.153 c
-.167 1.02 -.155 .942 -.155 .842 c
-.155 .741 -.167 .676 -.221 .566 c
-.276 .453 -.199 .532 -.403 .343 c
-.608 .155 -.795 .044 -.815 -.057 c
-.838 -.154 -.905 -.2 -.838 -.243 c
-.772 -.288 -.739 -.255 -.696 -.345 c
-.649 -.433 -.597 -.441 -.597 -.531 c
-.597 -.619 -.331 -.401 y
0 0 l
f
Q
EMC
EMC
/Cs8 cs 1 scn
/GS1 gs
q 1 0 0 1 310.847 699.364 cm 0 0 m
.057 1.02 l
.538 3.471 2.447 5.45 4.932 5.896 c
5.953 5.953 l
5.953 4.989 l
5.102 4.876 l
3.084 4.573 1.38 2.869 1.077 .85 c
.964 0 l
f*
Q
q 1 0 0 1 543.968 705.316 cm 0 0 m
1.02 -.057 l
3.505 -.503 5.415 -2.482 5.896 -4.932 c
5.953 -5.953 l
4.989 -5.953 l
4.876 -5.102 l
4.573 -3.084 2.869 -1.38 .85 -1.077 c
0 -.964 l
f*
Q
316.8 704.353 227.168 .96381 re
f
q 1 0 0 1 316.8 339.024 cm 0 0 m
-1.02 .113 l
-3.595 .603 -5.357 2.391 -5.896 4.932 c
-5.953 6.009 l
-4.989 6.009 l
-4.876 5.102 l
-4.451 2.969 -2.967 1.505 -.85 1.077 c
0 1.02 l
f*
Q
q 1 0 0 1 549.921 345.033 cm 0 0 m
-.057 -1.077 l
-.635 -3.613 -2.325 -5.435 -4.932 -5.896 c
-5.953 -6.009 l
-5.953 -4.989 l
-5.102 -4.932 l
-3.031 -4.621 -1.455 -2.936 -1.077 -.907 c
-.964 0 l
f*
Q
316.8 339.024 227.168 1.0205 re
f
310.847 345.033 .96378 354.331 re
f
548.957 345.033 .96381 354.331 re
f
q
328.252 695.338 m
532.573 695.338 l
532.573 582.123 l
328.252 582.123 l
W n
q
204.461 0 0 113.216 328.252 582.123 cm
/Im1 Do
Q
Q
BT
/F4 1 Tf
9.9626 0 0 9.9626 327.7983 564.2077 Tm
0 0 0 rg
0 Tc
[(FIG.)-337.6(1.)]TJ
/F8 1 Tf
3.8696 0 TD
[(Drug)-307.6(administrati)-14.8(on)-301.2(was)-303.3(condu)-8.8(cted)]TJ
-3.8696 -1.2974 TD
[(using)-303.1()49(joints)-11.7(,)46.9()-298.1(the)-304.7(most)-304.7(comm)-9.2(on)-301.2(method)-309.2(of)]TJ
0 -1.3031 TD
[(administer)-9.9(ing)-300.2(ca)-7.2(nnabis)-8(.)]TJ
7.4718 0 0 6.641 427.1243 542.7211 Tm
(11)Tj
9.9626 0 0 9.9626 437.7826 538.2991 Tm
[()49(Study)-306.1(dru)-9(g)49.1()-303.8(region)]TJ
-11.0397 -1.2974 TD
[(contained)-277.3(a)-272.1(mixtur)-9.4(e)-273.9(o)0(f)-272(66.6)-8.6(7)-167.2(m)0(g)-270.9(c)0(a)-7.2(nnabis)-275.4(\(activ)-10.7(e)]TJ
0 -1.3031 TD
[(or)-297.9(place)-8(bo\))-306.1(and)-301.9(311)-171.5(mg)-305.1(tobacco)-308.6(\(active)-307.4(or)]TJ
0 -1.2974 TD
[(placebo)-8.9(\))-299.4(dependent)-310.3(on)-301.2(co)-7.8(ndition)-307.8(\(Table)-305.2(1\).)-303.7(The)]TJ
0 -1.3031 TD
[()49(placebo)-295.6(toba)-8(cco)-289.2(ller)45.2()-292.4(region)-291.5(conta)-9.2(ined)-290.9(311)-171.5(mg)]TJ
0 -1.2974 TD
[(of)-300.4(place)-8(bo)-302.6(tobacco)-308.6(at)-303(the)-304.7(bottom)-310.4(of)-300.4(the)-304.7(joint)]TJ
0 -1.3031 TD
[(\(nearest)-308(to)-303.6(the)-304.7(mouth\),)-306.6(which)-307.8(was)-303.3(not)-303.5(smok)-10.7(ed.)]TJ
0 -1.2974 TD
[(This)-264.1(ller)-265.6(was)-269.2(added)-265.6(to)-269.4(improve)-272.7(complia)-8.9(nce)-265.1(with)]TJ
T*
[(the)-299(xe)-7.2(d)-303(inhalation)-308.7(procedure,)-314.5(as)-303.9(puff)-301(vol)-8.6(ume)]TJ
0 -1.3031 TD
[(typically)-305.7(d)-7.1(ecreases)-308.8(toward)-305.7(the)-304.7(end)-303.7(of)-306.1(the)-299(join)-9.6(t,)]TJ
0 -1.2974 TD
[(probabl)-9.3(y)-266.1(due)-269.2(to)-269.4(rising)-270.4(he)-6.4(at.)]TJ
7.4718 0 0 6.641 443.5085 413.2346 Tm
(18)Tj
9.9626 0 0 9.9626 453.77 408.8125 Tm
[(The)-268.6(stop)-274.1(line)-271.1(is)-263.7(th)-8(e)]TJ
-12.6444 -1.3031 TD
[(point)-292.1(at)-297.3(which)-296.4(participa)-10.9(nts)-290.2(stopped)-300.3(smok)-10.7(ing)-288.8(th)-8(e)]TJ
0 -1.2974 TD
[(joint,)-304.3(separati)-12.5(ng)-301.6(the)-304.7(two)-302.9(regions)-10.3(.)-298.1(I)0(t)-302.6(was)-303.3(mark)-9.2(ed)]TJ
0 -1.3031 TD
[(1)-167.2(c)0(m)-302(after)-305.3(the)-304.7()49(study)-309(drug)-9()49()-298.1(regi)-7.4(on)-301.2(to)-303.6(ensure)]TJ
0 -1.2974 TD
[(complete)-311.1(inhalation.)]TJ
7.9702 0 0 7.9702 59.7543 755.2061 Tm
(Hindocha,)Tj
/F11 1 Tf
4.4955 0 TD
[(et)-300.9(al.;)-304.2(Cannabis)-291.4(and)-292.6(Cannabinoid)-296.1(Research)]TJ
/F8 1 Tf
17.7544 0 TD
[(2017,)-302.4(2.1)]TJ
-22.2499 -1.2021 TD
[(http://online)10(.liebertpub.com)7(/doi/10.10)9.8(89/can.2017)10.5(.0024)]TJ
59.978 1.2021 TD
(219)Tj
ET
endstream
endobj
68 0 obj
<>stream
Adobe d C
s !1AQa"q2B#R3b$r%C4Scs5D'6Tdt&
EFVU(eufv7GWgw8HXhx)9IYiy*:JZjz ? Nlٳf͛6lٳf͛6lٳf͛6lٳf͛6ləhiIE&6>_vyq˭Yiwz~]٬fE
|i_ZZf]OH|,\fD ǐN\yu?VZg[
X`iEn2ҕO7t 5jVa̓X_A+`m
P:Lr9}jUK7մoN-~OEkc`3 ?`u]笷R):Eζ^S{8NбX8
OlV?
\ajZzA$*'.yQ@>ȾlQ