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Measurement of liver blood flow: a review.

Seifalian, AM; Stansby, GP; Hobbs, KE; Hawkes, DJ; Colchester, AC; (1991) Measurement of liver blood flow: a review. HPB Surg , 4 (3) 171 - 186. Gold open access

Abstract

The study of hepatic haemodynamics is of importance in understanding both hepatic physiology and disease processes as well as assessing the effects of portosystemic shunting and liver transplantation. The liver has the most complicated circulation of any organ and many physiological and pathological processes can affect it. This review surveys the methods available for assessing liver blood flow, examines the different parameters being measured and outlines problems of applicability and interpretation for each technique. The classification of these techniques is to some extent arbitrary and several so called "different" methods may share certain common principles. The methods reviewed have been classified into two groups (Table 1): those primarily reflecting flow through discrete vessels or to the whole organ and those used to assess local microcirculatory blood flow. All techniques have their advantages and disadvantages and in some situations a combination may provide the most information. In addition, because of the many factors affecting liver blood flow and sinusoidal perfusion, readings in a single subject may vary depending on positioning, recent food intake, anxiety, anaesthesia and drug therapy. This must be borne in mind if different studies are to be meaningfully compared.

Type:Article
Title:Measurement of liver blood flow: a review.
Location:SWITZERLAND
Open access status:An open access publication
Publisher version:http://www.hindawi.com/journals/hpb/
Language:English
Additional information:PMCID: PMC2423638
Keywords:Angiography, Dye Dilution Technique, Humans, Lasers, Liver Circulation, Magnetic Resonance Imaging, Microspheres, Radionuclide Angiography, Radionuclide Imaging, Ultrasonics, Ultrasonography
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of) > Research Department of General Surgery
UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering

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