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Localization of spontaneous bursting neuronal activity in the preterm human brain with simultaneous EEG-fMRI

Arichi, T; Whitehead, K; Barone, G; Pressler, R; Padormo, F; Edwards, AD; Fabrizi, L; (2017) Localization of spontaneous bursting neuronal activity in the preterm human brain with simultaneous EEG-fMRI. eLIFE , 6 , Article e27814. 10.7554/eLife.27814. Green open access

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Abstract

Electroencephalographic recordings from the developing human brain are characterized by spontaneous neuronal bursts, the most common of which is the delta brush. Although similar events in animal models are known to occur in areas of immature cortex and drive their development, their origin in humans has not yet been identified. Here, we use simultaneous EEG-fMRI to localise the source of delta brush events in 10 preterm infants aged 32–36 postmenstrual weeks. The most frequent patterns were left and right posterior-temporal delta brushes which were associated in the left hemisphere with ipsilateral BOLD activation in the insula only; and in the right hemisphere in both the insular and temporal cortices. This direct measure of neural and hemodynamic activity shows that the insula, one of the most densely connected hubs in the developing cortex, is a major source of the transient bursting events that are critical for brain maturation.

Type: Article
Title: Localization of spontaneous bursting neuronal activity in the preterm human brain with simultaneous EEG-fMRI
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.27814
Publisher version: http://dx.doi.org/10.7554/eLife.27814
Language: English
Additional information: © Copyright Arichi et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Keywords: Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, DEVELOPING NEOCORTICAL NETWORKS, FUNCTIONAL CONNECTIVITY, NEONATAL EEG, PERIVENTRICULAR LEUKOMALACIA, PREMATURE-INFANTS, CEREBRAL-CORTEX, NEURAL-NETWORKS, FULL-TERM, MATURATION, PATTERNS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/1575305
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