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The Lateral Habenula Circuitry: Reward Processing and Cognitive Control

Baker, PM; Jhou, T; Li, B; Matsumoto, M; Mizumori, SJY; Stephenson-Jones, M; Vicentic, A; (2016) The Lateral Habenula Circuitry: Reward Processing and Cognitive Control. The Journal of Neuroscience , 36 (45) pp. 11482-11488. 10.1523/JNEUROSCI.2350-16.2016. Green open access

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Abstract

There has been a growing interest in understanding the role of the lateral habenula (LHb) in reward processing, affect regulation, and goal-directed behaviors. The LHb gets major inputs from the habenula-projecting globus pallidus and the mPFC, sending its efferents to the dopaminergic VTA and SNc, serotonergic dorsal raphe nuclei, and the GABAergic rostromedial tegmental nucleus. Recent studies have made advances in our understanding of the LHb circuit organization, yet the precise mechanisms of its involvement in complex behaviors are largely unknown. To begin to address this unresolved question, we present here emerging cross-species perspectives with a goal to provide a more refined understanding of the role of the LHb circuits in reward and cognition. We begin by highlighting recent findings from rodent experiments using optogenetics, electrophysiology, molecular, pharmacology, and tracing techniques that reveal diverse neural phenotypes in the LHb circuits that may underlie previously undescribed behavioral functions. We then discuss results from electrophysiological studies in macaques that suggest that the LHb cooperates with the anterior cingulate cortex to monitor action outcomes and signal behavioral adjustment. Finally, we provide an integrated summary of cross-species findings and discuss how further research on the connectivity, neural signaling, and physiology of the LHb circuits can deepen our understanding of the role of the LHb in normal and maladaptive behaviors associated with mental illnesses and drug abuse.

Type: Article
Title: The Lateral Habenula Circuitry: Reward Processing and Cognitive Control
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.2350-16.2016
Publisher version: http://doi.org/10.1523/JNEUROSCI.2350-16.2016
Language: English
Additional information: Copyright © 2016 the authors. This article is published under Creative Commons Attribution 4.0 International (CC BY 4.0) license.
Keywords: anterior cingulate cortex, cognition, globus pallidus,lateral habenula, punishment,reward, rostromedial tegmental nucleus
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre
URI: http://discovery.ucl.ac.uk/id/eprint/1574574
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