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Noncoding RNAs in neurodegeneration

Salta, E; De Strooper, B; (2017) Noncoding RNAs in neurodegeneration. Nature Reviews Neuroscience 10.1038/nrn.2017.90. (In press).

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Abstract

The emerging complexity of the transcriptional landscape poses great challenges to our conventional preconceptions of how the genome regulates brain function and dysfunction. Non-protein-coding RNAs (ncRNAs) confer a high level of intricate and dynamic regulation of various molecular processes in the CNS and they have been implicated in neurodevelopment and brain ageing, as well as in synapse function and cognitive performance, in both health and disease. ncRNA-mediated processes may be involved in various aspects of the pathogenesis of neurodegenerative disorders. Understanding these events may help to develop novel diagnostic and therapeutic tools. Here, we provide an overview of the complex mechanisms that are affected by the diverse ncRNA classes that have been implicated in neurodegeneration.

Type: Article
Title: Noncoding RNAs in neurodegeneration
Location: England
DOI: 10.1038/nrn.2017.90
Publisher version: http://dx.doi.org/10.1038/nrn.2017.90
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Alzheimer's disease, Huntington's disease, miRNAs, Neurodegeneration, Non-coding RNAs, Parkinson's disease, Spinocerebellar ataxia
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Molecular Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/1573331
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