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Chromosome structure dynamics during the cell cycle: a structure to fit every phase

Barrington, C; Pezic, D; Hadjur, S; (2017) Chromosome structure dynamics during the cell cycle: a structure to fit every phase. The EMBO Journal , 36 (17) , Article e201798014. 10.15252/embj.201798014. Green open access

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Abstract

Chromosomes undergo dramatic morphological changes as cells advance through the cell cycle. Using powerful molecular and computational methods, several recent studies revealed an outstanding complexity of continuous structural changes accompanying cell cycle progression. In agreement with cell division being a fundamental cellular process, characteristic features of cell cycle stage‐specific genome structure are conserved from yeast to mouse. These studies further shine light on the critical roles that SMC complexes, already well known as fundamental regulators of chromosome topology, have in orchestrating structural dynamics throughout the cell cycle.

Type: Article
Title: Chromosome structure dynamics during the cell cycle: a structure to fit every phase
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.15252/embj.201798014
Publisher version: http://dx.doi.org/10.15252/embj.201798014
Language: English
Additional information: © 2017 The Authors. Published under the terms of the CC BY 4.0 license
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Cancer Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1573279
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