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Prevalence and risk factors of restrictive spirometry in a cohort of Peruvian adults

Siddharthan, T; Grigsby, M; Miele, CH; Bernabe-Ortiz, A; Miranda, JJ; Gilman, RH; Wise, RA; ... Checkley, W; + view all (2017) Prevalence and risk factors of restrictive spirometry in a cohort of Peruvian adults. The International Journal of Tuberculosis and Lung Disease , 21 (9) pp. 1062-1068. 10.5588/ijtld.17.0101. Green open access

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Abstract

INTRODUCTION: Few studies have described the prevalence of and lung function decline among those with a restrictive spirometric pattern (RSP) in low- and middle-income countries. METHODS: We analyzed prospective data from 3055 adults recruited across four diverse settings in Peru over a 3-year period. Multivariable logistic regression was used to study the association between the presence of restriction and associated risk factors. Multivariable linear mixed models were used to determine lung function decline. RESULTS: Among 3055 participants, the average age was 55.4 years (SD 12.4); 49% were male. Overall prevalence of RSP was 4.7%, ranging from 2.8% (Lima) to 6.9% (Tumbes). The odds of having RSP were higher among those who lived in a rural environment (OR 2.19, 95%CI 1.43–3.37), had a diagnosis of diabetes (OR 1.94, 95%CI 1.10–3.40) and among women (OR 2.09, 95%CI 1.41–3.09). When adjusting for baseline lung function, adults with RSP had accelerated decline in forced expiratory volume in 1 s (FEV1) compared with non-obstructed, non-restricted individuals. DISCUSSION: RSP is prevalent particularly among women and in individuals living in rural settings of Peru. When adjusted for baseline lung function, participants with RSP had accelerated rates of FEV1 decline. Our findings are consistent with the notion that RSP is an insidious inflammatory condition with deleterious effects of lung function decline.

Type: Article
Title: Prevalence and risk factors of restrictive spirometry in a cohort of Peruvian adults
Open access status: An open access version is available from UCL Discovery
DOI: 10.5588/ijtld.17.0101
Publisher version: http://dx.doi.org/10.5588/ijtld.17.0101
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, Respiratory System, chronic lung disease, lung function decline, OBSTRUCTIVE PULMONARY-DISEASE, LUNG-FUNCTION, VENTILATORY DYSFUNCTION, METABOLIC SYNDROME, REFERENCE VALUES, POPULATION, EPIDEMIOLOGY, INFLAMMATION, ASSOCIATION, PLATINO
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/1573176
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