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Modulation of motor cortex excitability by paired peripheral and transcranial magnetic stimulation

Kumru, H; Albu, S; Rothwell, J; Leon, D; Flores, C; Opisso, E; Tormos, JM; (2017) Modulation of motor cortex excitability by paired peripheral and transcranial magnetic stimulation. Clinical Neurophysiology , 128 (10) pp. 2043-2047. 10.1016/j.clinph.2017.06.041. Green open access

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Abstract

OBJECTIVE: Repetitive application of peripheral electrical stimuli paired with transcranial magnetic stimulation (rTMS) of M1 cortex at low frequency, known as paired associative stimulation (PAS), is an effective method to induce motor cortex plasticity in humans. Here we investigated the effects of repetitive peripheral magnetic stimulation (rPMS) combined with low frequency rTMS ('magnetic-PAS') on intracortical and corticospinal excitability and whether those changes were widespread or circumscribed to the cortical area controlling the stimulated muscle. METHODS: Eleven healthy subjects underwent three 10min stimulation sessions: 10HzrPMS alone, applied in trains of 5 stimuli every 10s (60 trains) on the extensor carpi radialis (ECR) muscle; rTMS alone at an intensity 120% of ECR threshold, applied over motor cortex of ECR and at a frequency of 0.1Hz (60 stimuli) and magnetic PAS, i.e., paired rPMS and rTMS. We recorded motor evoked potentials (MEPs) from ECR and first dorsal interosseous (FDI) muscles. We measured resting motor threshold, motor evoked potentials (MEP) amplitude at 120% of RMT, short intracortical inhibition (SICI) at interstimulus interval (ISI) of 2ms and intracortical facilitation (ICF) at an ISI of 15ms before and immediately after each intervention. RESULTS: Magnetic-PAS, but not rTMS or rPMS applied separately, increased MEP amplitude and reduced short intracortical inhibition in ECR but not in FDI muscle. CONCLUSION: Magnetic-PAS can increase corticospinal excitability and reduce intracortical inhibition. The effects may be specific for the area of cortical representation of the stimulated muscle. SIGNIFICANCE: Application of magnetic-PAS might be relevant for motor rehabilitation.

Type: Article
Title: Modulation of motor cortex excitability by paired peripheral and transcranial magnetic stimulation
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.clinph.2017.06.041
Publisher version: http://dx.doi.org/10.1016/j.clinph.2017.06.041
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Magnetic paired associative stimulation, Motor cortex excitability, Motor cortex plasticity, Repetitive peripheral magnetic stimulation, Adult, Electric Stimulation, Evoked Potentials, Motor, Female, Humans, Male, Middle Aged, Motor Cortex, Peripheral Nerves, Pyramidal Tracts, Transcranial Magnetic Stimulation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/1573113
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