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Mitochondrial calcium imbalance in Parkinson's disease

Ludtmann, MHR; Abramov, AY; (2018) Mitochondrial calcium imbalance in Parkinson's disease. Neuroscience Letters , 663 pp. 86-90. 10.1016/j.neulet.2017.08.044. Green open access

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Abstract

Multiple factors are involved in the mechanism(s) of neuronal loss in neurodegenerative disorders whilst mitochondria are thought to play a central role in neurodegeneration of Parkinson’s disease. Mitochondria are vital to cellular functions by supplying energy in form of ATP and affect cell physiology via calcium, ROS and signalling proteins. Changes in mitochondrial calcium homeostasis and ROS overproduction can induce cell death by triggering mitochondrial permeability transition pore opening. One of the major triggers for PTP is mitochondrial calcium overload. Mitochondrial Ca2+ homeostasis is regulated by electrogenic calcium uptake (via Ca2+ uniporter MCU) and efflux (in excitable cells via Na+/Ca2+ exchanger NCLX). NCLX inhibition has been described in a familial form of Parkinson’s disease where PINK-1 deficiency leads to a delayed calcium efflux and mitochondrial Ca2+ overload in response to physiological Ca2+ stimulation. Overexpression of NCLX in PINK-1 deficient neurons not only protects against mitochondrial calcium overload and calcium induced cell death but also restores mitochondrial bioenergetics in these neurons. Mitochondrial NCLX might therefore play an important role in the mechanism(s) of neurodegeneration in a variety of neurodegenerative disorders and activation of this exchanger may offer a novel therapeutic target.

Type: Article
Title: Mitochondrial calcium imbalance in Parkinson's disease
Location: Ireland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neulet.2017.08.044
Publisher version: https://doi.org/10.1016/j.neulet.2017.08.044
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Calcium, Mitochondria, NCLX, Neurons, Parkinson’s disease, Neurodegeneration
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/1573080
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