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Complex Roles of Myoglianin in Regulating Adult Performance and Lifespan

Augustin, H; Adcott, J; Elliott, CJH; Partridge, L; (2017) Complex Roles of Myoglianin in Regulating Adult Performance and Lifespan. Fly , 11 (4) pp. 284-289. 10.1080/19336934.2017.1369638. Green open access

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Abstract

Myoglianin, the Drosophila homolog of the secreted vertebrate proteins Myostatin and GDF-11, is an important regulator of neuronal modelling, and synapse function and morphology. While Myoglianin suppression during development elicits positive effects on the neuromuscular system, genetic manipulations of myoglianin expression levels have a varied effect on the outcome of performance tests in aging flies. Specifically, Myoglianin preserves jumping ability, has no effect on negative geotaxis, and negatively regulates flight performance in aging flies. In addition, Myoglianin exhibits a tissue-specific effect on longevity, with myoglianin upregulation in glial cells increasing the median lifespan. These findings indicate complex role for this TGF-β-like protein in governing neuromuscular signalling and consequent behavioural outputs and lifespan in adult flies.

Type: Article
Title: Complex Roles of Myoglianin in Regulating Adult Performance and Lifespan
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/19336934.2017.1369638
Publisher version: http://dx.doi.org/10.1080/19336934.2017.1369638
Language: English
Additional information: Copyright © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Drosophila, myoglianin, lifespan, performance
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/1572549
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