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Interferon γ-release assays for detecting latent tuberculosis infection in patients scheduled for anti-TNFα therapy.

Greveson, K; Murray, C; Toumpanakis, C; Epstein, O; Hamilton, M; Lipman, M; (2011) Interferon γ-release assays for detecting latent tuberculosis infection in patients scheduled for anti-TNFα therapy. Frontline Gastroenterol , 2 (1) pp. 26-31. 10.1136/fg.2010.000356.

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Abstract

Screening for, and treatment of, latent tuberculosis infection (LTBI) before anti- tumour necrosis factor α therapy has been shown to decrease the incidence of active tuberculosis by more than 80% and is recommended before initiation of treatment. In the absence of a 'gold standard' test for LTBI, current screening involves taking a clinical history of risk factors, chest radiograph and tuberculin skin test. Alternative cellular immune-based screening tests have been developed to detect Mycobacterium tuberculosis infection. This paper summarises the current position and advances in the use of newer screening strategies for LTBI.

Type: Article
Title: Interferon γ-release assays for detecting latent tuberculosis infection in patients scheduled for anti-TNFα therapy.
Location: England
DOI: 10.1136/fg.2010.000356
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/1572139
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