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Airway Basal Cell Heterogeneity and Lung Squamous Cell Carcinoma

Hynds, RE; Janes, SM; (2017) Airway Basal Cell Heterogeneity and Lung Squamous Cell Carcinoma. Cancer Prevention Research , 10 (9) pp. 491-493. 10.1158/1940-6207.CAPR-17-0202. Green open access

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Abstract

Basal cells are stem/progenitor cells that maintain airway homeostasis, enact repair following epithelial injury, and are a candidate cell-of-origin for lung squamous cell carcinoma. Heterogeneity of basal cells is recognized in terms of gene expression and differentiation capacity. In this Issue, Pagano and colleagues isolate a subset of immortalized basal cells that are characterized by high motility, suggesting that they might also be heterogeneous in their biophysical properties. Motility-selected cells displayed an increased ability to colonize the lung in vivo The possible implications of these findings are discussed in terms of basal cell heterogeneity, epithelial cell migration, and modeling of metastasis that occurs early in cancer evolution. Cancer Prev Res; 10(9); 1-3. ©2017 AACR.See related article by Pagano et al., p. 514.

Type: Article
Title: Airway Basal Cell Heterogeneity and Lung Squamous Cell Carcinoma
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1158/1940-6207.CAPR-17-0202
Publisher version: http://doi.org/10.1158/1940-6207.CAPR-17-0202
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/1571218
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