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The Yin and Yang of Memory Consolidation: Hippocampal and Neocortical

Genzel, L; Rossato, JI; Jacobse, J; Grieves, RM; Spooner, PA; Battaglia, FP; Fernandez, G; (2017) The Yin and Yang of Memory Consolidation: Hippocampal and Neocortical. PLoS Biology , 15 (1) , Article e2000531. 10.1371/journal.pbio.2000531. Green open access

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Abstract

While hippocampal and cortical mechanisms of memory consolidation have long been studied, their interaction is poorly understood. We sought to investigate potential interactions with respect to trace dominance, strengthening, and interference associated with postencoding novelty or sleep. A learning procedure was scheduled in a watermaze that placed the impact of novelty and sleep in opposition. Distinct behavioural manipulations—context preexposure or interference during memory retrieval—differentially affected trace dominance and trace survival, respectively. Analysis of immediate early gene expression revealed parallel up-regulation in the hippocampus and cortex, sustained in the hippocampus in association with novelty but in the cortex in association with sleep. These findings shed light on dynamically interacting mechanisms mediating the stabilization of hippocampal and neocortical memory traces. Hippocampal memory traces followed by novelty were more dominant by default but liable to interference, whereas sleep engaged a lasting stabilization of cortical traces and consequent trace dominance after preexposure.

Type: Article
Title: The Yin and Yang of Memory Consolidation: Hippocampal and Neocortical
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pbio.2000531
Publisher version: https://doi.org/10.1371/journal.pbio.2000531
Language: English
Additional information: Copyright © 2017 Genzel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
URI: http://discovery.ucl.ac.uk/id/eprint/1571162
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