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Auditory conflict and congruence in frontotemporal dementia

Clark, CN; Nicholas, JM; Agustus, JL; Hardy, CJD; Russell, LL; Brotherhood, EV; Dick, KM; ... Warren, JD; + view all (2017) Auditory conflict and congruence in frontotemporal dementia. Neuropsychologia , 104 pp. 144-156. 10.1016/j.neuropsychologia.2017.08.009. Green open access

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Abstract

Impaired analysis of signal conflict and congruence may contribute to diverse socio-emotional symptoms in frontotemporal dementias, however the underlying mechanisms have not been defined. Here we addressed this issue in patients with behavioural variant frontotemporal dementia (bvFTD; n=19) and semantic dementia (SD; n=10) relative to healthy older individuals (n=20). We created auditory scenes in which semantic and emotional congruity of constituent sounds were independently probed; associated tasks controlled for auditory perceptual similarity, scene parsing and semantic competence. Neuroanatomical correlates of auditory congruity processing were assessed using voxel-based morphometry. Relative to healthy controls, both the bvFTD and SD groups had impaired semantic and emotional congruity processing (after taking auditory control task performance into account) and reduced affective integration of sounds into scenes. Grey matter correlates of auditory semantic congruity processing were identified in distributed regions encompassing prefrontal, parieto-temporal and insular areas and correlates of auditory emotional congruity in partly overlapping temporal, insular and striatal regions. Our findings suggest that decoding of auditory signal relatedness may probe a generic cognitive mechanism and neural architecture underpinning frontotemporal dementia syndromes.

Type: Article
Title: Auditory conflict and congruence in frontotemporal dementia
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuropsychologia.2017.08.009
Publisher version: http://dx.doi.org/10.1016/j.neuropsychologia.2017....
Language: English
Additional information: This article is published under a Creative Commons licence Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Keywords: Auditory, conflict, congruence, emotion, frontotemporal dementia, semantic dementia
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > ION Central Administration
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/1570910
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