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Acute Respiratory Distress Syndrome.

Thompson, BT; Chambers, RC; Liu, KD; (2017) Acute Respiratory Distress Syndrome. The New England Journal of Medicine , 377 (6) pp. 562-572. 10.1056/NEJMra1608077. Green open access

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Abstract

Fifty years ago, Ashbaugh and colleagues described 12 patients with tachypnea, refractory hypoxemia, and diffuse opacities on chest radiographs after infection or trauma.1 Prominent hyaline membranes were seen lining the alveolar spaces of the lungs in 6 of the 7 patients who died, findings previously thought to be specific for the respiratory distress syndrome of the newborn. Thus, the term adult (later changed to acute) respiratory distress syndrome (ARDS) was proposed. Since ARDS was last reviewed in the Journal, 17 years ago,2 substantial progress has been made in the care of affected patients and those at risk for the disorder, with reductions in both incidence and mortality. However, ARDS remains a relatively common and lethal or disabling syndrome. In a recent international study involving 29,144 patients,3 10% of all patients admitted to the intensive care unit (ICU) and 23% of mechanically ventilated patients had ARDS. Mortality in the subgroup of patients with severe ARDS was 46%.3 Patients who survive this disorder are at high risk for cognitive decline, depression, post-traumatic stress disorder, and persistent skeletal-muscle weakness.

Type: Article
Title: Acute Respiratory Distress Syndrome.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1056/NEJMra1608077
Publisher version: https://doi.org/10.1056/NEJMra1608077
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/1570129
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