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Untangling the tauopathies: Current concepts of tau pathology and neurodegeneration

Ling, H; (2018) Untangling the tauopathies: Current concepts of tau pathology and neurodegeneration. Parkinsonism & Related Disorders , 46 (S1) S34-S38. 10.1016/j.parkreldis.2017.07.031. Green open access

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Abstract

Tau is the most common misfolded protein responsible for human neurodegenerative diseases. The identification of mutations in MAPT, the gene that encodes tau, causing dementia and parkinsonism established the notion that tau aggregation is responsible for the development of disease. An increased understanding of the pathway leading from conformational changes in tau protein and tau propagation to neuronal dysfunction, cell death and clinical manifestation will be the key for the development mechanism-based therapeutic strategies for tauopathies.

Type: Article
Title: Untangling the tauopathies: Current concepts of tau pathology and neurodegeneration
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.parkreldis.2017.07.031
Publisher version: http://doi.org/10.1016/j.parkreldis.2017.07.031
Language: English
Additional information: © 2017 Elsevier Ltd. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Chronic traumatic encephalopathy, Corticobasal degeneration, Frontotemporal dementia and parkinsonism linked to chromosome 17, Frontotemporal lobar degeneration, Progressive supranuclear palsy
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/1570081
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