Waksman, G;
(2017)
Structural and Molecular Biology of a Protein-Polymerizing Nanomachine for Pilus Biogenesis.
[Review].
J Mol Biol
, 429
(17)
pp. 2654-2666.
10.1016/j.jmb.2017.05.016.
Preview |
Text
1-s2.0-S0022283617302450-main.pdf - Published Version Download (1MB) | Preview |
Abstract
Bacteria produce protein polymers on their surface called pili or fimbriae that serve either as attachment devices or as conduits for secreted substrates. This review will focus on the chaperone-usher pathway of pilus biogenesis, a widespread assembly line for pilus production at the surface of Gram-negative bacteria and the archetypical protein-polymerizing nanomachine. Comparison with other nanomachines polymerizing other types of biological units, such as nucleotides during DNA replication, provides some unifying principles as to how multidomain proteins assemble biological polymers.
| Type: | Article |
|---|---|
| Title: | Structural and Molecular Biology of a Protein-Polymerizing Nanomachine for Pilus Biogenesis |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jmb.2017.05.016 |
| Publisher version: | https://doi.org/10.1016/j.jmb.2017.05.016 |
| Language: | English |
| Additional information: | © 2017 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Chaperone, DNA polymerase I, Nanomachine, Pilus biogenesis, Usher |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1569312 |
Archive Staff Only
 |
View Item |
