Lam, SD;
Das, S;
Sillitoe, I;
Orengo, C;
(2017)
An overview of comparative modelling and resources dedicated to large-scale modelling of genome sequences.
Acta Crystallographica Section D
, 73
pp. 628-640.
10.1107/S2059798317008920.
Preview |
Text
wa5112.pdf - Published Version Download (627kB) | Preview |
Abstract
Computational modelling of proteins has been a major catalyst in structural biology. Bioinformatics groups have exploited the repositories of known structures to predict high-quality structural models with high efficiency at low cost. This article provides an overview of comparative modelling, reviews recent developments and describes resources dedicated to large-scale comparative modelling of genome sequences. The value of subclustering protein domain superfamilies to guide the template-selection process is investigated. Some recent cases in which structural modelling has aided experimental work to determine very large macromolecular complexes are also cited.
| Type: | Article |
|---|---|
| Title: | An overview of comparative modelling and resources dedicated to large-scale modelling of genome sequences |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1107/S2059798317008920 |
| Publisher version: | http://dx.doi.org/10.1107/S2059798317008920 |
| Language: | English |
| Additional information: | This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
| Keywords: | Comparative modelling, protein structure prediction, template selection, template-based modelling |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1569305 |
Archive Staff Only
 |
View Item |
