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Tuneable Plasmonic Gold Dendrimer Nanochains for Sensitive Disease Detection

Ruiz Sanchez, AJ; Parolo, C; Miller, BS; Gray, ER; Schlegel, K; McKendry, RA; (2017) Tuneable Plasmonic Gold Dendrimer Nanochains for Sensitive Disease Detection. Journal of Materials Chemistry B , 35 pp. 7207-7434. 10.1039/C7TB01599B. Green open access

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Abstract

We report the development of a tuneable plasmonic nanochain immunoassay with increased sensitivity over traditional monodisperse nanoparticle lateral flow tests. Our approach takes advantage of the unique self-assembling properties of polyamidoamine dendrimers with gold nanoparticles in aqueous media to create one-dimensional nanochains, with a distinct red to blue colour change, attributable to a longitudinal plasmon resonance, which can be readily detected by eye and a digital camera. We optimise and characterise nanochain formation and stability using UV-visible spectroscopy, transmission electron microscopy and dynamic light scattering. As a proof-of-principle we focus on the application of nanochains for point-of-care diagnostics for p24, an important biomarker of early HIV infections and successfully detect p24 with a limit of detection of 5 ng ml−1 in pseudo-serum, 4 fold more sensitive than comparable studies with gold nanoparticles. These findings and underlying concepts highlight the potential of advanced functional organic–inorganic composite nanomaterials to diagnose infections, with broad applicability to non-communicable diseases.

Type: Article
Title: Tuneable Plasmonic Gold Dendrimer Nanochains for Sensitive Disease Detection
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/C7TB01599B
Publisher version: http://dx.doi.org/10.1039/C7TB01599B
Language: English
Additional information: Copyright © The Royal Society of Chemistry 2017 This Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > London Centre for Nanotechnology
URI: http://discovery.ucl.ac.uk/id/eprint/1567908
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