Castaldello, C;
Gubert, A;
Galvanin, F;
Casonato, A;
Padrini, R;
Barolo, M;
Bezzo, M;
(2017)
A Model-Based Support for Diagnosing von Willebrand Disease.
In:
Computer Aided Chemical Engineering.
(pp. pp. 2779-2784).
Elsevier: Barcelona, Spain.
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Abstract
Von Willebrand disease (VWD) is the most common inherited bleeding disease and is caused by deficiency or dysfunction of a multimeric glycoprotein, namely the von Willebrand factor (VWF). The disease is present in numerous subtypes, making the diagnosis through the classic 24-h DDAVP sampling protocol a difficult task. In this simulation study, a new simplified pharmacokinetic model is proposed with the aims of demonstrating that a shorter DDAVP clinical test can be devised and that indices, such as clearance, total amount of VWF released and multimeric ratio at basal state can be exploited with multivariate classification methods in order to help practitioners to reach a correct diagnosis.
| Type: | Proceedings paper |
|---|---|
| Title: | A Model-Based Support for Diagnosing von Willebrand Disease |
| Event: | ESCAPE 27 - 27th European Symposium on Computer Aided Process Engineering |
| Location: | Barcelona |
| Dates: | 01 October 2017 - 05 October 2017 |
| DOI: | 10.1016/B978-0-444-63965-3.50465-7 |
| Publisher version: | https://doi.org/10.1016/B978-0-444-63965-3.50465-7 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | von Willebrand disease, physiological model, model-based diagnosis, personalised medicine |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1566834 |
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