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Low-beta cortico-pallidal coherence decreases during movement and correlates with overall reaction time

van Wijk, BCM; Neumann, W-J; Schneider, G-H; Sander, TH; Litvak, V; Kühn, AA; (2017) Low-beta cortico-pallidal coherence decreases during movement and correlates with overall reaction time. NeuroImage , 159 pp. 1-8. 10.1016/j.neuroimage.2017.07.024. Green open access

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Abstract

Beta band oscillations (13-30 Hz) are a hallmark of cortical and subcortical structures that are part of the motor system. In addition to local population activity, oscillations also provide a means for synchronization of activity between regions. Here we examined the role of beta band coherence between the internal globus pallidus (GPi) and (motor) cortex during a simple reaction time task performed by nine patients with idiopathic dystonia. We recorded local field potentials from deep brain stimulation (DBS) electrodes implanted in bilateral GPi in combination with simultaneous whole-head magneto-encephalography (MEG). Patients responded to visually presented go or stop-signal cues by pressing a button with left or right hand. Although coherence between signals from DBS electrodes and MEG sensors was observed throughout the entire beta band, a significant movement-related decrease prevailed in lower beta frequencies (∼13-21 Hz). In addition, patients' absolute coherence values in this frequency range significantly correlated with their median reaction time during the task (p = 0.003, r = 0.89). These findings corroborate the recent idea of two functionally distinct frequency ranges within the beta band, as well as the anti-kinetic character of beta oscillations.

Type: Article
Title: Low-beta cortico-pallidal coherence decreases during movement and correlates with overall reaction time
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuroimage.2017.07.024
Publisher version: http://dx.doi.org/10.1016/j.neuroimage.2017.07.024
Language: English
Additional information: This article is under Creative Commons licence Attribution 4.0 International (CC BY 4.0)
Keywords: Beta oscillations, Coherence, Dystonia, Globus pallidus internus, Magneto-encephalography, Movement
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/1566581
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