UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Association between urinary biomarkers of total sugars intake and measures of obesity in a cross-sectional study

Campbell, R; Tasevska, N; Jackson, KG; Sagi-Kiss, V; di Paulo, N; Mindell, JS; Lister, SJ; ... Kuhnle, GGC; + view all (2017) Association between urinary biomarkers of total sugars intake and measures of obesity in a cross-sectional study. PLoS ONE , 12 (7) , Article e0179508. 10.1371/journal.pone.0179508. Green open access

[img]
Preview
Text (Published article)
Campbell_Association_urinary_biomarkers_VoR.pdf - ["content_typename_Published version" not defined]

Download (2MB) | Preview
[img]
Preview
Text (Table 1)
Campbell_Association_urinary_biomarkers_Table1.pdf

Download (85kB) | Preview
[img]
Preview
Text (Table 2)
Campbell_Association_urinary_biomarkers_Table2.pdf

Download (99kB) | Preview
[img]
Preview
Text (Table 3)
Campbell_Association_urinary_biomarkers_Table3.pdf

Download (205kB) | Preview
[img]
Preview
Text (Table 4)
Campbell_Association_urinary_biomarkers_Table4.pdf

Download (172kB) | Preview

Abstract

Obesity is an important modifiable risk factor for chronic diseases. While there is increasing focus on the role of dietary sugars, there remains a paucity of data establishing the association between sugar intake and obesity in the general public. The objective of this study was to investigate associations of estimated sugar intake with odds for obesity in a representative sample of English adults. We used data from 434 participants of the 2005 Health Survey of England. Biomarkers for total sugar intake were measured in 24 h urine samples and used to estimate intake. Linear and logistic regression analyses were used to investigate associations between biomarker-based estimated intake and measures of obesity (body mass intake (BMI), waist circumference and waist-to-hip ratio) and obesity risk, respectively. Estimated sugar intake was significantly associated with BMI, waist circumference and waist-to-hip ratio; these associations remained significant after adjustment for estimated protein intake as a marker of non-sugar energy intake. Estimated sugar intake was also associated with increased odds for obesity based on BMI (OR 1.02; 95%CI 1.00–1.04 per 10g), waist-circumference (1.03; 1.01–1.05) and waist-to-hip ratio (1.04; 1.02–1.06); all OR estimates remained significant after adjusting for estimated protein intake. Our results strongly support positive associations between total sugar intake, measures of obesity and likelihood of being obese. It is the first time that such an association has been shown in a nationally-representative sample of the general population using a validated biomarker. This biomarker could be used to monitor the efficacy of public health interventions to reduce sugar intake.

Type: Article
Title: Association between urinary biomarkers of total sugars intake and measures of obesity in a cross-sectional study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0179508
Publisher version: https://doi.org/10.1371/journal.pone.0179508
Language: English
Additional information: Copyright © 2017 Campbell et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: http://discovery.ucl.ac.uk/id/eprint/1565489
Downloads since deposit
187Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item