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Delta and gamma oscillations in operculo-insular cortex underlie innocuous cold thermosensation

Fardo, F; Vinding, MC; Allen, M; Jensen, TS; Finnerup, NB; (2017) Delta and gamma oscillations in operculo-insular cortex underlie innocuous cold thermosensation. Journal of Neurophysiology , 117 (5) pp. 1959-1968. 10.1152/jn.00843.2016. Green open access

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Abstract

Cold-sensitive and nociceptive neural pathways interact to shape the quality and intensity of thermal and pain perception. Yet the central processing of cold thermosensation in the human brain has not been extensively studied. Here, we used magnetoencephalography and EEG in healthy volunteers to investigate the time course (evoked fields and potentials) and oscillatory activity associated with the perception of cold temperature changes. Nonnoxious cold stimuli consisting of Δ3°C and Δ5°C decrements from an adapting temperature of 35°C were delivered on the dorsum of the left hand via a contact thermode. Cold-evoked fields peaked at around 240 and 500 ms, at peak latencies similar to the N1 and P2 cold-evoked potentials. Importantly, cold-related changes in oscillatory power indicated that innocuous thermosensation is mediated by oscillatory activity in the range of delta (1–4 Hz) and gamma (55–90 Hz) rhythms, originating in operculo-insular cortical regions. We suggest that delta rhythms coordinate functional integration between operculo-insular and frontoparietal regions, while gamma rhythms reflect local sensory processing in operculo-insular areas.

Type: Article
Title: Delta and gamma oscillations in operculo-insular cortex underlie innocuous cold thermosensation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1152/jn.00843.2016
Publisher version: http://doi.org/10.1152/jn.00843.2016
Language: English
Additional information: Copyright © the American Physiological Society. Licensed under Creative Commons Attribution CC-BY 3.0.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: http://discovery.ucl.ac.uk/id/eprint/1565399
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