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The cascade of increasingly deviant development that culminates in the onset of schizophrenia

Bramon, E; Kelly, J; Van Os, J; Murray, RM; (2001) The cascade of increasingly deviant development that culminates in the onset of schizophrenia. NeuroScience News , 4 (1) pp. 5-19.

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Abstract

Subtle alterations in brain development caused by gene(s) and early environmental hazards such as obstetric complications appear to play an important role in projecting some individuals on a trajectory towards schizophrenia. High risk and cohort studies demonstrate that pre-schizophrenic children are slow to walk and talk, and show an excess of minor neuromotor and cognitive difficulties, particularly in coordination and in receptive language. These neurocognitive problems and difficulties in interpersonal relations render pre-schizophrenic children increasingly alienated from their peers, and by age 11, they are more likely to harbour odd and paranoid ideas. One theory is that this cascade of increasingly deviant development is then compounded by brain maturational changes during adolescence with a resultant liability of the dopaminergic response to stress. As a result, the individual is then more susceptible to the effects of the abuse of dopamine releasing drugs, and of other risk-increasing factors such as being a migrant or being brought up in a city; social isolation may be the factor underlying several of the social risk factors.

Type: Article
Title: The cascade of increasingly deviant development that culminates in the onset of schizophrenia
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: http://discovery.ucl.ac.uk/id/eprint/1565004
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