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Flies and fish: Birds of a feather

Tamai, TK; Vardhanabhuti, V; Arthur, S; Foulkes, NS; Whitmore, D; (2003) Flies and fish: Birds of a feather. JOURNAL OF NEUROENDOCRINOLOGY , 15 (4) 344 - 349.

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Abstract

The identification of specific clock-containing structures has been a major endeavour of the circadian field for many years. This has lead to the identification of many key components of the circadian system, including the suprachiasmatic nucleus in mammals, and the eyes and pineal glands in lower vertebrates. However, the idea that these structures represent the only clocks in animals has been challenged by the discovery of peripheral pacemakers in most organs and tissues, and even a number of cell lines. In Drosophila , and vertebrates such as the zebrafish, these peripheral clocks appear to be highly autonomous, being set directly by the environmental light/dark cycle. However, a hierarchy of clocks may still exist in mammals. In this review, we examine some of the current views regarding peripheral clocks, their organization and how they are entrained.

Type: Article
Title: Flies and fish: Birds of a feather
Location: ABERDEEN, SCOTLAND
Keywords: peripheral circadian clock, entrainment, zebrafish, Drosophila, light, glucocorticoid, PERIPHERAL CIRCADIAN OSCILLATORS, GENE-EXPRESSION, CLOCK GENE, SUPRACHIASMATIC NUCLEUS, RHYTHMIC EXPRESSION, PARS TUBERALIS, DROSOPHILA, SYSTEM, MOUSE, CELLS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/156379
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