UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Proteomics profiling of interactome dynamics by colocalisation analysis (COLA)

Mardakheh, FK; Sailem, HZ; Kümper, S; Tape, CJ; McCully, RR; Paul, A; Anjomani-Virmouni, S; ... Bakal, C; + view all (2017) Proteomics profiling of interactome dynamics by colocalisation analysis (COLA). Molecular BioSystems , 13 (1) pp. 92-105. 10.1039/c6mb00701e. Green open access

[img]
Preview
Text (Published article)
c6mb00701e.pdf - ["content_typename_Published version" not defined]

Download (4MB) | Preview
[img]
Preview
Text (Supplementary data 1)
Mardakheh_Proteomics_profiling_interactome_S1.pdf

Download (107kB) | Preview
[img] Spreadsheet (Supplementary data 2)
Mardakheh_Proteomics_profiling_interactome_S2.xlsx

Download (1MB)

Abstract

Localisation and protein function are intimately linked in eukaryotes, as proteins are localised to specific compartments where they come into proximity of other functionally relevant proteins. Significant co-localisation of two proteins can therefore be indicative of their functional association. We here present COLA, a proteomics based strategy coupled with a bioinformatics framework to detect protein-protein co-localisations on a global scale. COLA reveals functional interactions by matching proteins with significant similarity in their subcellular localisation signatures. The rapid nature of COLA allows mapping of interactome dynamics across different conditions or treatments with high precision.

Type: Article
Title: Proteomics profiling of interactome dynamics by colocalisation analysis (COLA)
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c6mb00701e
Publisher version: http://dx.doi.org/10.1039/c6mb00701e
Language: English
Additional information: This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (http://creativecommons.org/licenses/by-nc/3.0/)
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/1563705
Downloads since deposit
104Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item